Loss of alpha 10 beta 1 integrin expression leads to moderate dysfunction of growth plate chondrocytes
(2005) In Journal of Cell Science 118(5). p.929-936- Abstract
- Integrin alpha 10 beta 1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the alpha 10 integrin during development, we generated mice carrying a constitutive deletion of the alpha 10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth characterized by a disturbed columnar arrangement of chondrocytes, abnormal chondrocyte shape and reduced chondrocyte proliferation. Electron microscopy of growth plates from newborn mice revealed an increased number of apoptotic chondrocytes and reduced density of the collagen fibrillar network compared to these structures... (More)
- Integrin alpha 10 beta 1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the alpha 10 integrin during development, we generated mice carrying a constitutive deletion of the alpha 10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth characterized by a disturbed columnar arrangement of chondrocytes, abnormal chondrocyte shape and reduced chondrocyte proliferation. Electron microscopy of growth plates from newborn mice revealed an increased number of apoptotic chondrocytes and reduced density of the collagen fibrillar network compared to these structures in control mice. These results demonstrate that integrin alpha 10 beta 1 plays a specific role in growth plate morphogenesis and function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/246486
- author
- Bengtsson, T ; Aszodi, A ; Nicolae, C ; Hunziker, EB ; Lundgren-Akerlund, E and Fässler, Reinhard LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cartilage, proliferation, growth plate, integrin, knockout
- in
- Journal of Cell Science
- volume
- 118
- issue
- 5
- pages
- 929 - 936
- publisher
- The Company of Biologists Ltd
- external identifiers
-
- pmid:15713743
- wos:000228378400009
- scopus:17044396261
- pmid:15713743
- ISSN
- 0021-9533
- DOI
- 10.1242/jcs.01678
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Pathology (013031100), Pathology, (Lund) (013030000)
- id
- ced7a406-ab1e-456d-8ec5-5007519975b1 (old id 246486)
- date added to LUP
- 2016-04-01 11:43:25
- date last changed
- 2022-01-26 17:17:38
@article{ced7a406-ab1e-456d-8ec5-5007519975b1,
abstract = {{Integrin alpha 10 beta 1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the alpha 10 integrin during development, we generated mice carrying a constitutive deletion of the alpha 10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth characterized by a disturbed columnar arrangement of chondrocytes, abnormal chondrocyte shape and reduced chondrocyte proliferation. Electron microscopy of growth plates from newborn mice revealed an increased number of apoptotic chondrocytes and reduced density of the collagen fibrillar network compared to these structures in control mice. These results demonstrate that integrin alpha 10 beta 1 plays a specific role in growth plate morphogenesis and function.}},
author = {{Bengtsson, T and Aszodi, A and Nicolae, C and Hunziker, EB and Lundgren-Akerlund, E and Fässler, Reinhard}},
issn = {{0021-9533}},
keywords = {{cartilage; proliferation; growth plate; integrin; knockout}},
language = {{eng}},
number = {{5}},
pages = {{929--936}},
publisher = {{The Company of Biologists Ltd}},
series = {{Journal of Cell Science}},
title = {{Loss of alpha 10 beta 1 integrin expression leads to moderate dysfunction of growth plate chondrocytes}},
url = {{http://dx.doi.org/10.1242/jcs.01678}},
doi = {{10.1242/jcs.01678}},
volume = {{118}},
year = {{2005}},
}