The impact of hypoglycaemia on daily functioning among adults with diabetes : a prospective observational study using the Hypo-METRICS app
(2024) In Diabetologia 67(10). p.2160-2174- Abstract
Aims/hypothesis: The aim of this work was to examine the impact of hypoglycaemia on daily functioning among adults with type 1 diabetes or insulin-treated type 2 diabetes, using the novel Hypo-METRICS app. Methods: For 70 consecutive days, 594 adults (type 1 diabetes, n=274; type 2 diabetes, n=320) completed brief morning and evening Hypo-METRICS ‘check-ins’ about their experienced hypoglycaemia and daily functioning. Participants wore a blinded glucose sensor (i.e. data unavailable to the participants) for the study duration. Days and nights with or without person-reported hypoglycaemia (PRH) and/or sensor-detected hypoglycaemia (SDH) were compared using multilevel regression models. Results: Participants submitted a mean ± SD of... (More)
Aims/hypothesis: The aim of this work was to examine the impact of hypoglycaemia on daily functioning among adults with type 1 diabetes or insulin-treated type 2 diabetes, using the novel Hypo-METRICS app. Methods: For 70 consecutive days, 594 adults (type 1 diabetes, n=274; type 2 diabetes, n=320) completed brief morning and evening Hypo-METRICS ‘check-ins’ about their experienced hypoglycaemia and daily functioning. Participants wore a blinded glucose sensor (i.e. data unavailable to the participants) for the study duration. Days and nights with or without person-reported hypoglycaemia (PRH) and/or sensor-detected hypoglycaemia (SDH) were compared using multilevel regression models. Results: Participants submitted a mean ± SD of 86.3±12.5% morning and 90.8±10.7% evening check-ins. For both types of diabetes, SDH alone had no significant associations with the changes in daily functioning scores. However, daytime and night-time PRH (with or without SDH) were significantly associated with worsening of energy levels, mood, cognitive functioning, negative affect and fear of hypoglycaemia later that day or while asleep. In addition, night-time PRH (with or without SDH) was significantly associated with worsening of sleep quality (type 1 and type 2 diabetes) and memory (type 2 diabetes). Further, daytime PRH (with or without SDH), was associated with worsening of fear of hyperglycaemia while asleep (type 1 diabetes), memory (type 1 and type 2 diabetes) and social functioning (type 2 diabetes). Conclusions/interpretation: This prospective, real-world study reveals impact on several domains of daily functioning following PRH but not following SDH alone. These data suggest that the observed negative impact is mainly driven by subjective awareness of hypoglycaemia (i.e. PRH), through either symptoms or sensor alerts/readings and/or the need to take action to prevent or treat episodes. Graphical Abstract: (Figure presented.)
(Less)
- author
- author collaboration
- organization
- publishing date
- 2024-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Daily functioning, Ecological momentary assessment, Hypoglycaemia, Quality of life
- in
- Diabetologia
- volume
- 67
- issue
- 10
- pages
- 15 pages
- publisher
- Springer
- external identifiers
-
- pmid:39080044
- scopus:85200048713
- ISSN
- 0012-186X
- DOI
- 10.1007/s00125-024-06233-1
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © The Author(s) 2024.
- id
- ceeb99d1-20a3-40fc-9f73-76a72abbd881
- date added to LUP
- 2024-11-27 10:02:26
- date last changed
- 2025-07-10 17:36:25
@article{ceeb99d1-20a3-40fc-9f73-76a72abbd881,
abstract = {{<p>Aims/hypothesis: The aim of this work was to examine the impact of hypoglycaemia on daily functioning among adults with type 1 diabetes or insulin-treated type 2 diabetes, using the novel Hypo-METRICS app. Methods: For 70 consecutive days, 594 adults (type 1 diabetes, n=274; type 2 diabetes, n=320) completed brief morning and evening Hypo-METRICS ‘check-ins’ about their experienced hypoglycaemia and daily functioning. Participants wore a blinded glucose sensor (i.e. data unavailable to the participants) for the study duration. Days and nights with or without person-reported hypoglycaemia (PRH) and/or sensor-detected hypoglycaemia (SDH) were compared using multilevel regression models. Results: Participants submitted a mean ± SD of 86.3±12.5% morning and 90.8±10.7% evening check-ins. For both types of diabetes, SDH alone had no significant associations with the changes in daily functioning scores. However, daytime and night-time PRH (with or without SDH) were significantly associated with worsening of energy levels, mood, cognitive functioning, negative affect and fear of hypoglycaemia later that day or while asleep. In addition, night-time PRH (with or without SDH) was significantly associated with worsening of sleep quality (type 1 and type 2 diabetes) and memory (type 2 diabetes). Further, daytime PRH (with or without SDH), was associated with worsening of fear of hyperglycaemia while asleep (type 1 diabetes), memory (type 1 and type 2 diabetes) and social functioning (type 2 diabetes). Conclusions/interpretation: This prospective, real-world study reveals impact on several domains of daily functioning following PRH but not following SDH alone. These data suggest that the observed negative impact is mainly driven by subjective awareness of hypoglycaemia (i.e. PRH), through either symptoms or sensor alerts/readings and/or the need to take action to prevent or treat episodes. Graphical Abstract: (Figure presented.)</p>}},
author = {{Søholm, Uffe and Broadley, Melanie and Zaremba, Natalie and Divilly, Patrick and Baumann, Petra Martina and Mahmoudi, Zeinab and Martine-Edith, Gilberte and Mader, Julia K. and Cigler, Monika and Brøsen, Julie Maria Bøggild and Vaag, Allan and Heller, Simon and Pedersen-Bjergaard, Ulrik and McCrimmon, Rory J. and Renard, Eric and Evans, Mark and de Galan, Bastiaan and Abbink, Evertine and Amiel, Stephanie A. and Hendrieckx, Christel and Speight, Jane and Choudhary, Pratik and Pouwer, Frans}},
issn = {{0012-186X}},
keywords = {{Daily functioning; Ecological momentary assessment; Hypoglycaemia; Quality of life}},
language = {{eng}},
number = {{10}},
pages = {{2160--2174}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{The impact of hypoglycaemia on daily functioning among adults with diabetes : a prospective observational study using the Hypo-METRICS app}},
url = {{http://dx.doi.org/10.1007/s00125-024-06233-1}},
doi = {{10.1007/s00125-024-06233-1}},
volume = {{67}},
year = {{2024}},
}