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Pharmacokinetics of the MRI contrast agent gadobutrol in common marmoset monkeys (Callithrix jacchus)

Helms, Gunther LU ; Schlumbohm, Christina; Garea-Rodriguez, Enrique; Dechent, Peter and Fuchs, Eberhard (2016) In Journal of Medical Primatology 45(6). p.290-296
Abstract
Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3 mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis. Results: Slow injection (1.5 minutes) resulted in an elimination half-time of 26±4 minutes. After bolus injection (15 seconds), elimination was much slower (62±8 minutes) with 45%... (More)
Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3 mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis. Results: Slow injection (1.5 minutes) resulted in an elimination half-time of 26±4 minutes. After bolus injection (15 seconds), elimination was much slower (62±8 minutes) with 45% larger distribution volumes. Importantly, more gadobutrol entered the cerebrospinal fluid. Conclusions: Slow injection and a latency of about 20 minutes are recommended to avoid extravasation. Application of a triple dose of gadobutrol compensates for the fast elimination in healthy marmosets. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Medical Primatology
volume
45
issue
6
pages
7 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:84978718681
  • WOS:000387363700002
ISSN
0047-2565
DOI
10.1111/jmp.12227
language
English
LU publication?
yes
id
cef5bfb2-9fff-4c2c-b789-4b87c16298f8
date added to LUP
2016-08-09 10:55:23
date last changed
2017-02-23 10:53:55
@article{cef5bfb2-9fff-4c2c-b789-4b87c16298f8,
  abstract     = {Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3 mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis. Results: Slow injection (1.5 minutes) resulted in an elimination half-time of 26±4 minutes. After bolus injection (15 seconds), elimination was much slower (62±8 minutes) with 45% larger distribution volumes. Importantly, more gadobutrol entered the cerebrospinal fluid. Conclusions: Slow injection and a latency of about 20 minutes are recommended to avoid extravasation. Application of a triple dose of gadobutrol compensates for the fast elimination in healthy marmosets.},
  author       = {Helms, Gunther and Schlumbohm, Christina and Garea-Rodriguez, Enrique and Dechent, Peter and Fuchs, Eberhard},
  issn         = {0047-2565},
  language     = {eng},
  month        = {07},
  number       = {6},
  pages        = {290--296},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Medical Primatology},
  title        = {Pharmacokinetics of the MRI contrast agent gadobutrol in common marmoset monkeys (Callithrix jacchus)},
  url          = {http://dx.doi.org/10.1111/jmp.12227},
  volume       = {45},
  year         = {2016},
}