The β-cell capacity for insulin secretion in microdissected pancreatic islets from obese-hyperglycemic mice
(1969) In Life Sciences 8(2 PART 2). p.53-59- Abstract
The pancreatic islets in obese-hyperglycemic mice display a normal response of insulin secretion when stimulated with glucose in vitro. This indicates that the impaired glucose metabolism is due to extra-pancreatic factors rather than to deficient β-cell function. In fact, the pancreas of these mice is a useful source from which to isolate large numbers of mammalian β-cells suitable for studies of the synthesis and secretion of insulin. The very large islets secreted less insulin than the normally sized ones. Whether this can be attributed to a low concentration gradient for insulin in the central part of the large islets or to the presence of α1-cells remains obscure.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/cef7743f-9fc3-4b32-b10c-6d88304d01ba
- author
- Lernmark, Åke LU and Hellman, Bo
- publishing date
- 1969-01-15
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Life Sciences
- volume
- 8
- issue
- 2 PART 2
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:4905547
- scopus:0014675355
- ISSN
- 0024-3205
- DOI
- 10.1016/0024-3205(69)90117-9
- language
- English
- LU publication?
- no
- id
- cef7743f-9fc3-4b32-b10c-6d88304d01ba
- date added to LUP
- 2019-09-18 12:26:41
- date last changed
- 2024-03-13 08:23:06
@article{cef7743f-9fc3-4b32-b10c-6d88304d01ba, abstract = {{<p>The pancreatic islets in obese-hyperglycemic mice display a normal response of insulin secretion when stimulated with glucose in vitro. This indicates that the impaired glucose metabolism is due to extra-pancreatic factors rather than to deficient β-cell function. In fact, the pancreas of these mice is a useful source from which to isolate large numbers of mammalian β-cells suitable for studies of the synthesis and secretion of insulin. The very large islets secreted less insulin than the normally sized ones. Whether this can be attributed to a low concentration gradient for insulin in the central part of the large islets or to the presence of α<sub>1</sub>-cells remains obscure.</p>}}, author = {{Lernmark, Åke and Hellman, Bo}}, issn = {{0024-3205}}, language = {{eng}}, month = {{01}}, number = {{2 PART 2}}, pages = {{53--59}}, publisher = {{Elsevier}}, series = {{Life Sciences}}, title = {{The β-cell capacity for insulin secretion in microdissected pancreatic islets from obese-hyperglycemic mice}}, url = {{http://dx.doi.org/10.1016/0024-3205(69)90117-9}}, doi = {{10.1016/0024-3205(69)90117-9}}, volume = {{8}}, year = {{1969}}, }