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The β-cell capacity for insulin secretion in microdissected pancreatic islets from obese-hyperglycemic mice

Lernmark, Åke LU orcid and Hellman, Bo (1969) In Life Sciences 8(2 PART 2). p.53-59
Abstract

The pancreatic islets in obese-hyperglycemic mice display a normal response of insulin secretion when stimulated with glucose in vitro. This indicates that the impaired glucose metabolism is due to extra-pancreatic factors rather than to deficient β-cell function. In fact, the pancreas of these mice is a useful source from which to isolate large numbers of mammalian β-cells suitable for studies of the synthesis and secretion of insulin. The very large islets secreted less insulin than the normally sized ones. Whether this can be attributed to a low concentration gradient for insulin in the central part of the large islets or to the presence of α1-cells remains obscure.

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author
and
publishing date
type
Contribution to journal
publication status
published
subject
in
Life Sciences
volume
8
issue
2 PART 2
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:4905547
  • scopus:0014675355
ISSN
0024-3205
DOI
10.1016/0024-3205(69)90117-9
language
English
LU publication?
no
id
cef7743f-9fc3-4b32-b10c-6d88304d01ba
date added to LUP
2019-09-18 12:26:41
date last changed
2024-03-13 08:23:06
@article{cef7743f-9fc3-4b32-b10c-6d88304d01ba,
  abstract     = {{<p>The pancreatic islets in obese-hyperglycemic mice display a normal response of insulin secretion when stimulated with glucose in vitro. This indicates that the impaired glucose metabolism is due to extra-pancreatic factors rather than to deficient β-cell function. In fact, the pancreas of these mice is a useful source from which to isolate large numbers of mammalian β-cells suitable for studies of the synthesis and secretion of insulin. The very large islets secreted less insulin than the normally sized ones. Whether this can be attributed to a low concentration gradient for insulin in the central part of the large islets or to the presence of α<sub>1</sub>-cells remains obscure.</p>}},
  author       = {{Lernmark, Åke and Hellman, Bo}},
  issn         = {{0024-3205}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{2 PART 2}},
  pages        = {{53--59}},
  publisher    = {{Elsevier}},
  series       = {{Life Sciences}},
  title        = {{The β-cell capacity for insulin secretion in microdissected pancreatic islets from obese-hyperglycemic mice}},
  url          = {{http://dx.doi.org/10.1016/0024-3205(69)90117-9}},
  doi          = {{10.1016/0024-3205(69)90117-9}},
  volume       = {{8}},
  year         = {{1969}},
}