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'From blood to blood' : De-differentiation of hematopoietic progenitors to stem cells

Pereira, Carlos Filipe LU ; Lemischka, Ihor R. and Moore, Kateri (2014) In EMBO Journal 33(14). p.1511-1513
Abstract

Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.

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author
publishing date
type
Contribution to journal
publication status
published
in
EMBO Journal
volume
33
issue
14
pages
3 pages
publisher
Oxford University Press
external identifiers
  • scopus:84904561142
ISSN
0261-4189
DOI
10.15252/embj.201488980
language
English
LU publication?
no
id
cefe6a97-9e37-4216-9a68-c5968e171996
date added to LUP
2017-10-02 17:26:31
date last changed
2017-10-12 09:35:54
@article{cefe6a97-9e37-4216-9a68-c5968e171996,
  abstract     = {<p>Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.</p>},
  author       = {Pereira, Carlos Filipe and Lemischka, Ihor R. and Moore, Kateri},
  issn         = {0261-4189},
  language     = {eng},
  month        = {07},
  number       = {14},
  pages        = {1511--1513},
  publisher    = {Oxford University Press},
  series       = {EMBO Journal},
  title        = {'From blood to blood' : De-differentiation of hematopoietic progenitors to stem cells},
  url          = {http://dx.doi.org/10.15252/embj.201488980},
  volume       = {33},
  year         = {2014},
}