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BAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health

Tran, Hien Thi LU ; Wan, Murphy Lam Yim LU ; Ambite, Ines LU orcid ; Cavalera, Michele LU ; Grossi, Mario LU ; Háček, Jaromir ; Esmaeili, Parisa LU ; Carneiro, António N.B.M. LU ; Chaudhuri, Arunima LU and Ahmadi, Shahram LU , et al. (2024) In Scientific Reports 14(1).
Abstract

Though new targeted therapies for colorectal cancer, which progresses from local intestinal tumors to metastatic disease, are being developed, tumor specificity remains an important problem, and side effects a major concern. Here, we show that the protein-fatty acid complex BAMLET (bovine alpha-lactalbumin made lethal to tumor cells) can act as a peroral treatment for colorectal cancer. ApcMin/+ mice, which carry mutations relevant to hereditary and sporadic human colorectal cancer, that received BAMLET in the drinking water showed long-term protection against tumor development and decreased expression of tumor growth-, migration-, metastasis- and angiogenesis-related genes. BAMLET treatment via drinking water inhibited the... (More)

Though new targeted therapies for colorectal cancer, which progresses from local intestinal tumors to metastatic disease, are being developed, tumor specificity remains an important problem, and side effects a major concern. Here, we show that the protein-fatty acid complex BAMLET (bovine alpha-lactalbumin made lethal to tumor cells) can act as a peroral treatment for colorectal cancer. ApcMin/+ mice, which carry mutations relevant to hereditary and sporadic human colorectal cancer, that received BAMLET in the drinking water showed long-term protection against tumor development and decreased expression of tumor growth-, migration-, metastasis- and angiogenesis-related genes. BAMLET treatment via drinking water inhibited the Wnt/β-catenin and PD-1 signaling pathways and prolonged survival without evidence of toxicity. Systemic disease in the lungs, livers, spleens, and kidneys, which accompanied tumor progression, was inhibited by BAMLET treatment. The metabolic response to BAMLET included carbohydrate and lipid metabolism, which were inhibited in tumor prone ApcMin/+ mice and weakly regulated in C57BL/6 mice, suggesting potential health benefits of peroral BAMLET administration in addition to the potent antitumor effects. Together, these findings suggest that BAMLET administration in the drinking water maintains antitumor pressure by removing emergent cancer cells and reprogramming gene expression in intestinal and extra-intestinal tissues.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
14
issue
1
article number
3838
publisher
Nature Publishing Group
external identifiers
  • pmid:38360830
  • scopus:85185240359
ISSN
2045-2322
DOI
10.1038/s41598-024-54040-w
language
English
LU publication?
yes
id
cf0596ad-1eea-410a-afeb-96fad06a8352
date added to LUP
2024-03-14 11:36:18
date last changed
2024-04-25 08:13:32
@article{cf0596ad-1eea-410a-afeb-96fad06a8352,
  abstract     = {{<p>Though new targeted therapies for colorectal cancer, which progresses from local intestinal tumors to metastatic disease, are being developed, tumor specificity remains an important problem, and side effects a major concern. Here, we show that the protein-fatty acid complex BAMLET (bovine alpha-lactalbumin made lethal to tumor cells) can act as a peroral treatment for colorectal cancer. Apc<sup>Min/+</sup> mice, which carry mutations relevant to hereditary and sporadic human colorectal cancer, that received BAMLET in the drinking water showed long-term protection against tumor development and decreased expression of tumor growth-, migration-, metastasis- and angiogenesis-related genes. BAMLET treatment via drinking water inhibited the Wnt/β-catenin and PD-1 signaling pathways and prolonged survival without evidence of toxicity. Systemic disease in the lungs, livers, spleens, and kidneys, which accompanied tumor progression, was inhibited by BAMLET treatment. The metabolic response to BAMLET included carbohydrate and lipid metabolism, which were inhibited in tumor prone Apc<sup>Min/+</sup> mice and weakly regulated in C57BL/6 mice, suggesting potential health benefits of peroral BAMLET administration in addition to the potent antitumor effects. Together, these findings suggest that BAMLET administration in the drinking water maintains antitumor pressure by removing emergent cancer cells and reprogramming gene expression in intestinal and extra-intestinal tissues.</p>}},
  author       = {{Tran, Hien Thi and Wan, Murphy Lam Yim and Ambite, Ines and Cavalera, Michele and Grossi, Mario and Háček, Jaromir and Esmaeili, Parisa and Carneiro, António N.B.M. and Chaudhuri, Arunima and Ahmadi, Shahram and Svanborg, Catharina}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{BAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-54040-w}},
  doi          = {{10.1038/s41598-024-54040-w}},
  volume       = {{14}},
  year         = {{2024}},
}