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PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog

Wideman, Jeremy G ; Balacco, Dario L ; Fieblinger, Tim LU and Richards, Thomas A (2018) In F1000Research 7. p.1088-1088
Abstract

Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a "functional ortholog" of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, which affects the interpretation of the data with respect to the evolution of ER-mitochondria tethering. Our phylogenetic analyses show that PDZD8 co-occurs with ERMES components in lineages closely related to animals solidifying its identity as a paralog of Mmm1. Additionally, we identify two related paralogs, one specific to flagellated fungi,... (More)

Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a "functional ortholog" of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, which affects the interpretation of the data with respect to the evolution of ER-mitochondria tethering. Our phylogenetic analyses show that PDZD8 co-occurs with ERMES components in lineages closely related to animals solidifying its identity as a paralog of Mmm1. Additionally, we identify two related paralogs, one specific to flagellated fungi, and one present only in unicellular relatives of animals. These results point to a complex evolutionary history of ER-mitochondria tethering involving multiple gene gains and losses in the lineage leading to animals and fungi.

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publication status
published
subject
in
F1000Research
volume
7
pages
1088 - 1088
publisher
F1000 Research Ltd.
external identifiers
  • scopus:85054932584
  • pmid:30109028
ISSN
2046-1402
DOI
10.12688/f1000research.15523.1
language
English
LU publication?
yes
id
cf18e2e5-cbeb-49e1-939b-bbb2c389445a
date added to LUP
2018-08-31 09:15:43
date last changed
2021-10-06 04:57:31
@article{cf18e2e5-cbeb-49e1-939b-bbb2c389445a,
  abstract     = {<p>Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a "functional ortholog" of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, which affects the interpretation of the data with respect to the evolution of ER-mitochondria tethering. Our phylogenetic analyses show that PDZD8 co-occurs with ERMES components in lineages closely related to animals solidifying its identity as a paralog of Mmm1. Additionally, we identify two related paralogs, one specific to flagellated fungi, and one present only in unicellular relatives of animals. These results point to a complex evolutionary history of ER-mitochondria tethering involving multiple gene gains and losses in the lineage leading to animals and fungi.</p>},
  author       = {Wideman, Jeremy G and Balacco, Dario L and Fieblinger, Tim and Richards, Thomas A},
  issn         = {2046-1402},
  language     = {eng},
  pages        = {1088--1088},
  publisher    = {F1000 Research Ltd.},
  series       = {F1000Research},
  title        = {PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog},
  url          = {http://dx.doi.org/10.12688/f1000research.15523.1},
  doi          = {10.12688/f1000research.15523.1},
  volume       = {7},
  year         = {2018},
}