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Reduction of gain and time constant of vestibulo-ocular reflex in man induced by diazepam and thiopental

Padoan, S; Korttila, K; Magnusson, M LU ; Pyykkö, I. and Schalén, L LU (1990) In Journal of Vestibular Research: Equilibrium and Orientation 1(1). p.97-104
Abstract

The effect of intravenous administration of two sedatives, diazepam (0.3 mg/kg) and thiopental (6.0 mg/kg), on the vestibulo-ocular reflex (VOR) in man was investigated on 9 volunteers. The VOR was evoked with a velocity step rotation test and gain and time constant of prerotatory and postrotatory nystagmus were measured. Both drugs reduced VOR gain. Diazepam-induced reduction lasted 8 h and thiopental-induced reduction 1 h. A reduction of the VOR time constant was found lasting about 1 h for both drugs, but with a tendency for the thiopental effect to last longer. These findings, not previously described in man, differ from what has been found in macaques and rabbits injected with diazepam. The reduction of gain and time constant were... (More)

The effect of intravenous administration of two sedatives, diazepam (0.3 mg/kg) and thiopental (6.0 mg/kg), on the vestibulo-ocular reflex (VOR) in man was investigated on 9 volunteers. The VOR was evoked with a velocity step rotation test and gain and time constant of prerotatory and postrotatory nystagmus were measured. Both drugs reduced VOR gain. Diazepam-induced reduction lasted 8 h and thiopental-induced reduction 1 h. A reduction of the VOR time constant was found lasting about 1 h for both drugs, but with a tendency for the thiopental effect to last longer. These findings, not previously described in man, differ from what has been found in macaques and rabbits injected with diazepam. The reduction of gain and time constant were not correlated with the blood concentration of either drug. The present results suggest that in man the VOR gain and time constant are both reduced by different types of sedatives although with different time courses. On the basis of previously shown effect of alertness on the VOR, it is hypothesized that diazepam and thiopental, besides having a specific effect on central nervous system structures important to the VOR, also induce reduction of the VOR through a general sedation of the CNS.

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keywords
Adult, Diazepam, Female, Humans, Injections, Intravenous, Male, Nystagmus, Optokinetic, Reflex, Vestibulo-Ocular, Rotation, Thiopental, Time Factors, Journal Article, Research Support, Non-U.S. Gov't
in
Journal of Vestibular Research: Equilibrium and Orientation
volume
1
issue
1
pages
97 - 104
publisher
IOS Press
external identifiers
  • scopus:0025574070
ISSN
0957-4271
language
English
LU publication?
no
id
cf231e4d-583a-441d-b7cd-1e4e1ec851b6
date added to LUP
2017-05-03 12:54:51
date last changed
2017-05-07 04:53:04
@article{cf231e4d-583a-441d-b7cd-1e4e1ec851b6,
  abstract     = {<p>The effect of intravenous administration of two sedatives, diazepam (0.3 mg/kg) and thiopental (6.0 mg/kg), on the vestibulo-ocular reflex (VOR) in man was investigated on 9 volunteers. The VOR was evoked with a velocity step rotation test and gain and time constant of prerotatory and postrotatory nystagmus were measured. Both drugs reduced VOR gain. Diazepam-induced reduction lasted 8 h and thiopental-induced reduction 1 h. A reduction of the VOR time constant was found lasting about 1 h for both drugs, but with a tendency for the thiopental effect to last longer. These findings, not previously described in man, differ from what has been found in macaques and rabbits injected with diazepam. The reduction of gain and time constant were not correlated with the blood concentration of either drug. The present results suggest that in man the VOR gain and time constant are both reduced by different types of sedatives although with different time courses. On the basis of previously shown effect of alertness on the VOR, it is hypothesized that diazepam and thiopental, besides having a specific effect on central nervous system structures important to the VOR, also induce reduction of the VOR through a general sedation of the CNS.</p>},
  author       = {Padoan, S and Korttila, K and Magnusson, M and Pyykkö, I. and Schalén, L},
  issn         = {0957-4271},
  keyword      = {Adult,Diazepam,Female,Humans,Injections, Intravenous,Male,Nystagmus, Optokinetic,Reflex, Vestibulo-Ocular,Rotation,Thiopental,Time Factors,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {97--104},
  publisher    = {IOS Press},
  series       = {Journal of Vestibular Research: Equilibrium and Orientation},
  title        = {Reduction of gain and time constant of vestibulo-ocular reflex in man induced by diazepam and thiopental},
  volume       = {1},
  year         = {1990},
}