Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Expression pattern of apolipoprotein M during mouse and human embryogenesis

Zhang, XY ; Jiao, GQ ; Hurtig, M ; Dong, X ; Zheng, L ; Luo, GH ; Nilsson-Ehle, Peter LU ; Ye, Q and Xu, Ning LU (2004) In Acta Histochemica 106(2). p.123-128
Abstract
Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportions in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene encoding apoM is present in all mammalian genomes. The identity of the apoM gene of human, rat and mouse is over 80%. However, the (patho)physiological functions of apoM are unknown yet. In the present study, we investigated apoM expression patterns during mouse and human embryogenesis. ApoM transcripts were detectable in mouse embryos from day 7.5 to day 18.5. ApoM was expressed at low levels at day 7.5, its expression increased significantly at day 9.7, decreased at day 10.5, and then increased... (More)
Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportions in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene encoding apoM is present in all mammalian genomes. The identity of the apoM gene of human, rat and mouse is over 80%. However, the (patho)physiological functions of apoM are unknown yet. In the present study, we investigated apoM expression patterns during mouse and human embryogenesis. ApoM transcripts were detectable in mouse embryos from day 7.5 to day 18.5. ApoM was expressed at low levels at day 7.5, its expression increased significantly at day 9.7, decreased at day 10.5, and then increased continually up to day 18.5. ApoM-positive cells appeared mainly in liver of day-12 embryos as detected by in situ hybridization. In day-15 embryos, apoM was expressed in both liver and kidney. During human embryogenesis, apoM was mainly expressed in liver and kidney and little was found in small intestine as determined by mRNA array of human fetal. normal tissues. ApoM was also detected in stomach and skeletal muscle in early stages of embryogenesis (3-5 months). (C) 2004 Elsevier GmbH. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
embryogenesis, apolipoprotein M, in situ hybridization, liver, kidney
in
Acta Histochemica
volume
106
issue
2
pages
123 - 128
publisher
Elsevier
external identifiers
  • wos:000221541800006
  • pmid:15147633
  • scopus:3843065770
ISSN
0065-1281
DOI
10.1016/j.acthis.2003.11.004
language
English
LU publication?
yes
id
cf6e6399-c42d-4846-b6ce-8cd0a2690f7a (old id 277448)
date added to LUP
2016-04-01 12:38:03
date last changed
2022-01-27 07:44:57
@article{cf6e6399-c42d-4846-b6ce-8cd0a2690f7a,
  abstract     = {{Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportions in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene encoding apoM is present in all mammalian genomes. The identity of the apoM gene of human, rat and mouse is over 80%. However, the (patho)physiological functions of apoM are unknown yet. In the present study, we investigated apoM expression patterns during mouse and human embryogenesis. ApoM transcripts were detectable in mouse embryos from day 7.5 to day 18.5. ApoM was expressed at low levels at day 7.5, its expression increased significantly at day 9.7, decreased at day 10.5, and then increased continually up to day 18.5. ApoM-positive cells appeared mainly in liver of day-12 embryos as detected by in situ hybridization. In day-15 embryos, apoM was expressed in both liver and kidney. During human embryogenesis, apoM was mainly expressed in liver and kidney and little was found in small intestine as determined by mRNA array of human fetal. normal tissues. ApoM was also detected in stomach and skeletal muscle in early stages of embryogenesis (3-5 months). (C) 2004 Elsevier GmbH. All rights reserved.}},
  author       = {{Zhang, XY and Jiao, GQ and Hurtig, M and Dong, X and Zheng, L and Luo, GH and Nilsson-Ehle, Peter and Ye, Q and Xu, Ning}},
  issn         = {{0065-1281}},
  keywords     = {{embryogenesis; apolipoprotein M; in situ hybridization; liver; kidney}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{123--128}},
  publisher    = {{Elsevier}},
  series       = {{Acta Histochemica}},
  title        = {{Expression pattern of apolipoprotein M during mouse and human embryogenesis}},
  url          = {{http://dx.doi.org/10.1016/j.acthis.2003.11.004}},
  doi          = {{10.1016/j.acthis.2003.11.004}},
  volume       = {{106}},
  year         = {{2004}},
}