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Preterm infant circulating sex steroid levels are not altered by transfusion with adult male plasma : a retrospective multicentre cohort study

Nilsson, Anders K. ; Hellgren, Gunnel ; Sjöbom, Ulrika ; Landin, Andreas ; Ryberg, Henrik ; Wackernagel, Dirk ; Ley, David LU ; Hansen Pupp, Ingrid LU orcid ; Poutanen, Matti and Ohlsson, Claes , et al. (2022) In Archives of Disease in Childhood: Fetal and Neonatal Edition 107(6). p.577-582
Abstract

Objective To determine if plasma transfusions with male donor plasma to very preterm infants affect circulatory levels of sex steroids. Design and patients Retrospective multicentre cohort study in 19 infants born at gestational age <29 weeks requiring plasma transfusion during their first week of life. Setting Three neonatal intensive care units in Sweden. Main outcome measures Concentrations of sex steroids and sex hormone-binding globulin (SHBG) in donor plasma and infant plasma measured before and after a plasma transfusion and at 6, 12, 24 and 72 hours. Results The concentrations of progesterone, dehydroepiandrosterone and androstenedione were significantly lower in donor plasma than in infant plasma before the transfusion... (More)

Objective To determine if plasma transfusions with male donor plasma to very preterm infants affect circulatory levels of sex steroids. Design and patients Retrospective multicentre cohort study in 19 infants born at gestational age <29 weeks requiring plasma transfusion during their first week of life. Setting Three neonatal intensive care units in Sweden. Main outcome measures Concentrations of sex steroids and sex hormone-binding globulin (SHBG) in donor plasma and infant plasma measured before and after a plasma transfusion and at 6, 12, 24 and 72 hours. Results The concentrations of progesterone, dehydroepiandrosterone and androstenedione were significantly lower in donor plasma than in infant plasma before the transfusion (median (Q1-Q3) 37.0 (37.0-37.0), 1918 (1325-2408) and 424 (303-534) vs 901 (599-1774), 4119 (2801-14 645) and 842 (443-1684) pg/mL), while oestrone and oestradiol were higher in donor plasma (17.4 (10.4-20.1) and 16.0 (11.7-17.2) vs 3.1 (1.1-10.2) and 0.25 (0.25-0.25) pg/mL). Median testosterone and dihydrotestosterone (DHT) levels were 116-fold and 21-fold higher in donor plasma than pre-transfusion levels in female infants, whereas the corresponding difference was not present in male infants. Plasma sex steroid levels were unchanged after completed transfusion compared with pre-transfusion levels, irrespective of the gender of the receiving infant. The SHBG concentration was significantly higher in donor than in recipient plasma (22.8 (17.1-33.5) vs 10.2 (9.1-12.3) nmol/L) before transfusion but did not change in the infants after the transfusion. Conclusions A single transfusion of adult male plasma to preterm infants had no impact on circulating sex steroid levels.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
endocrinology, intensive care units, neonatal, neonatology
in
Archives of Disease in Childhood: Fetal and Neonatal Edition
volume
107
issue
6
pages
6 pages
publisher
BMJ Publishing Group
external identifiers
  • scopus:85140415484
  • pmid:35232892
ISSN
1359-2998
DOI
10.1136/archdischild-2021-323433
language
English
LU publication?
yes
id
cf8e1afd-ce2b-4fca-b19e-48a624e61ad4
date added to LUP
2022-12-13 11:28:55
date last changed
2024-02-18 10:40:42
@article{cf8e1afd-ce2b-4fca-b19e-48a624e61ad4,
  abstract     = {{<p>Objective To determine if plasma transfusions with male donor plasma to very preterm infants affect circulatory levels of sex steroids. Design and patients Retrospective multicentre cohort study in 19 infants born at gestational age &lt;29 weeks requiring plasma transfusion during their first week of life. Setting Three neonatal intensive care units in Sweden. Main outcome measures Concentrations of sex steroids and sex hormone-binding globulin (SHBG) in donor plasma and infant plasma measured before and after a plasma transfusion and at 6, 12, 24 and 72 hours. Results The concentrations of progesterone, dehydroepiandrosterone and androstenedione were significantly lower in donor plasma than in infant plasma before the transfusion (median (Q1-Q3) 37.0 (37.0-37.0), 1918 (1325-2408) and 424 (303-534) vs 901 (599-1774), 4119 (2801-14 645) and 842 (443-1684) pg/mL), while oestrone and oestradiol were higher in donor plasma (17.4 (10.4-20.1) and 16.0 (11.7-17.2) vs 3.1 (1.1-10.2) and 0.25 (0.25-0.25) pg/mL). Median testosterone and dihydrotestosterone (DHT) levels were 116-fold and 21-fold higher in donor plasma than pre-transfusion levels in female infants, whereas the corresponding difference was not present in male infants. Plasma sex steroid levels were unchanged after completed transfusion compared with pre-transfusion levels, irrespective of the gender of the receiving infant. The SHBG concentration was significantly higher in donor than in recipient plasma (22.8 (17.1-33.5) vs 10.2 (9.1-12.3) nmol/L) before transfusion but did not change in the infants after the transfusion. Conclusions A single transfusion of adult male plasma to preterm infants had no impact on circulating sex steroid levels.</p>}},
  author       = {{Nilsson, Anders K. and Hellgren, Gunnel and Sjöbom, Ulrika and Landin, Andreas and Ryberg, Henrik and Wackernagel, Dirk and Ley, David and Hansen Pupp, Ingrid and Poutanen, Matti and Ohlsson, Claes and Hellstrom, Ann}},
  issn         = {{1359-2998}},
  keywords     = {{endocrinology; intensive care units, neonatal; neonatology}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{6}},
  pages        = {{577--582}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Archives of Disease in Childhood: Fetal and Neonatal Edition}},
  title        = {{Preterm infant circulating sex steroid levels are not altered by transfusion with adult male plasma : a retrospective multicentre cohort study}},
  url          = {{http://dx.doi.org/10.1136/archdischild-2021-323433}},
  doi          = {{10.1136/archdischild-2021-323433}},
  volume       = {{107}},
  year         = {{2022}},
}