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First therapeutic use of Artesunate in treatment of human herpesvirus 6B myocarditis in a child.

Hakacova, Nina LU ; Klingel, Karin ; Kandolf, Reinhard ; Engdahl, Elin ; Fogdell-Hahn, Anna and Higgins, Thomas (2013) In Journal of Clinical Virology 57(2). p.157-160
Abstract
BACKGROUND: Human herpesvirus 6 (HHV-6) is an important cause of fulminant or acute viral myocarditis. However, insufficiency of standard antiviral treatment against HHV-6 is an emerging problem. OBJECTIVES: To describe the case of child with HHV-6 myocarditis who was treated by unloading with a left ventricular assist device and Artesunate. STUDY DESIGN: Case report supported by histological and viral diagnoses via a combination of histology/immunohistochemistry and polymerase chain reaction techniques performed on cardiac tissues before and after treatment. RESULTS: Following therapeutic intervention, the clinical status and heart function improved. Endomyocardial biopsies revealed decreased levels of HHV-6B DNA in the myocardium and the... (More)
BACKGROUND: Human herpesvirus 6 (HHV-6) is an important cause of fulminant or acute viral myocarditis. However, insufficiency of standard antiviral treatment against HHV-6 is an emerging problem. OBJECTIVES: To describe the case of child with HHV-6 myocarditis who was treated by unloading with a left ventricular assist device and Artesunate. STUDY DESIGN: Case report supported by histological and viral diagnoses via a combination of histology/immunohistochemistry and polymerase chain reaction techniques performed on cardiac tissues before and after treatment. RESULTS: Following therapeutic intervention, the clinical status and heart function improved. Endomyocardial biopsies revealed decreased levels of HHV-6B DNA in the myocardium and the disappearance of histological findings in support of lymphocytic myocarditis. Left ventricular assist device could be explanted. No adverse effects of Artesunate were noted. CONCLUSIONS: In addition to existing heart failure treatments, Artesunate can be considered as an effective candidate for clinical use in cases of HHV-6B associated myocarditis. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Virology
volume
57
issue
2
pages
157 - 160
publisher
Elsevier
external identifiers
  • wos:000318563900013
  • pmid:23473961
  • scopus:84877004815
  • pmid:23473961
ISSN
1386-6532
DOI
10.1016/j.jcv.2013.02.005
language
English
LU publication?
yes
id
cf980db5-9400-4243-a27c-064b82bce8eb (old id 3628377)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23473961?dopt=Abstract
date added to LUP
2016-04-01 09:57:01
date last changed
2022-02-24 20:52:37
@article{cf980db5-9400-4243-a27c-064b82bce8eb,
  abstract     = {{BACKGROUND: Human herpesvirus 6 (HHV-6) is an important cause of fulminant or acute viral myocarditis. However, insufficiency of standard antiviral treatment against HHV-6 is an emerging problem. OBJECTIVES: To describe the case of child with HHV-6 myocarditis who was treated by unloading with a left ventricular assist device and Artesunate. STUDY DESIGN: Case report supported by histological and viral diagnoses via a combination of histology/immunohistochemistry and polymerase chain reaction techniques performed on cardiac tissues before and after treatment. RESULTS: Following therapeutic intervention, the clinical status and heart function improved. Endomyocardial biopsies revealed decreased levels of HHV-6B DNA in the myocardium and the disappearance of histological findings in support of lymphocytic myocarditis. Left ventricular assist device could be explanted. No adverse effects of Artesunate were noted. CONCLUSIONS: In addition to existing heart failure treatments, Artesunate can be considered as an effective candidate for clinical use in cases of HHV-6B associated myocarditis.}},
  author       = {{Hakacova, Nina and Klingel, Karin and Kandolf, Reinhard and Engdahl, Elin and Fogdell-Hahn, Anna and Higgins, Thomas}},
  issn         = {{1386-6532}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{157--160}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Clinical Virology}},
  title        = {{First therapeutic use of Artesunate in treatment of human herpesvirus 6B myocarditis in a child.}},
  url          = {{http://dx.doi.org/10.1016/j.jcv.2013.02.005}},
  doi          = {{10.1016/j.jcv.2013.02.005}},
  volume       = {{57}},
  year         = {{2013}},
}