First therapeutic use of Artesunate in treatment of human herpesvirus 6B myocarditis in a child.
(2013) In Journal of Clinical Virology 57(2). p.157-160- Abstract
- BACKGROUND: Human herpesvirus 6 (HHV-6) is an important cause of fulminant or acute viral myocarditis. However, insufficiency of standard antiviral treatment against HHV-6 is an emerging problem. OBJECTIVES: To describe the case of child with HHV-6 myocarditis who was treated by unloading with a left ventricular assist device and Artesunate. STUDY DESIGN: Case report supported by histological and viral diagnoses via a combination of histology/immunohistochemistry and polymerase chain reaction techniques performed on cardiac tissues before and after treatment. RESULTS: Following therapeutic intervention, the clinical status and heart function improved. Endomyocardial biopsies revealed decreased levels of HHV-6B DNA in the myocardium and the... (More)
- BACKGROUND: Human herpesvirus 6 (HHV-6) is an important cause of fulminant or acute viral myocarditis. However, insufficiency of standard antiviral treatment against HHV-6 is an emerging problem. OBJECTIVES: To describe the case of child with HHV-6 myocarditis who was treated by unloading with a left ventricular assist device and Artesunate. STUDY DESIGN: Case report supported by histological and viral diagnoses via a combination of histology/immunohistochemistry and polymerase chain reaction techniques performed on cardiac tissues before and after treatment. RESULTS: Following therapeutic intervention, the clinical status and heart function improved. Endomyocardial biopsies revealed decreased levels of HHV-6B DNA in the myocardium and the disappearance of histological findings in support of lymphocytic myocarditis. Left ventricular assist device could be explanted. No adverse effects of Artesunate were noted. CONCLUSIONS: In addition to existing heart failure treatments, Artesunate can be considered as an effective candidate for clinical use in cases of HHV-6B associated myocarditis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3628377
- author
- Hakacova, Nina LU ; Klingel, Karin ; Kandolf, Reinhard ; Engdahl, Elin ; Fogdell-Hahn, Anna and Higgins, Thomas
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Virology
- volume
- 57
- issue
- 2
- pages
- 157 - 160
- publisher
- Elsevier
- external identifiers
-
- wos:000318563900013
- pmid:23473961
- scopus:84877004815
- pmid:23473961
- ISSN
- 1386-6532
- DOI
- 10.1016/j.jcv.2013.02.005
- language
- English
- LU publication?
- yes
- id
- cf980db5-9400-4243-a27c-064b82bce8eb (old id 3628377)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23473961?dopt=Abstract
- date added to LUP
- 2016-04-01 09:57:01
- date last changed
- 2022-02-24 20:52:37
@article{cf980db5-9400-4243-a27c-064b82bce8eb, abstract = {{BACKGROUND: Human herpesvirus 6 (HHV-6) is an important cause of fulminant or acute viral myocarditis. However, insufficiency of standard antiviral treatment against HHV-6 is an emerging problem. OBJECTIVES: To describe the case of child with HHV-6 myocarditis who was treated by unloading with a left ventricular assist device and Artesunate. STUDY DESIGN: Case report supported by histological and viral diagnoses via a combination of histology/immunohistochemistry and polymerase chain reaction techniques performed on cardiac tissues before and after treatment. RESULTS: Following therapeutic intervention, the clinical status and heart function improved. Endomyocardial biopsies revealed decreased levels of HHV-6B DNA in the myocardium and the disappearance of histological findings in support of lymphocytic myocarditis. Left ventricular assist device could be explanted. No adverse effects of Artesunate were noted. CONCLUSIONS: In addition to existing heart failure treatments, Artesunate can be considered as an effective candidate for clinical use in cases of HHV-6B associated myocarditis.}}, author = {{Hakacova, Nina and Klingel, Karin and Kandolf, Reinhard and Engdahl, Elin and Fogdell-Hahn, Anna and Higgins, Thomas}}, issn = {{1386-6532}}, language = {{eng}}, number = {{2}}, pages = {{157--160}}, publisher = {{Elsevier}}, series = {{Journal of Clinical Virology}}, title = {{First therapeutic use of Artesunate in treatment of human herpesvirus 6B myocarditis in a child.}}, url = {{http://dx.doi.org/10.1016/j.jcv.2013.02.005}}, doi = {{10.1016/j.jcv.2013.02.005}}, volume = {{57}}, year = {{2013}}, }