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Vasectomy and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Byrne, Karl Smith ; Castaño, Jose Maria ; Chirlaque, Maria Dolores ; Lilja, Hans LU orcid ; Agudo, Antonio ; Ardanaz, Eva LU ; Rodríguez-Barranco, Miguel ; Boeing, Heiner ; Kaaks, Rudolf and Khaw, Kay Tee , et al. (2017) In Journal of Clinical Oncology 35(12). p.1297-1303
Abstract

Purpose Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate cancer. Patients and Methods A total of 84, 753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information on vasectomy status (15% with vasectomy) at recruitment and were followed for incidence of prostate cancer and death. We estimated the association of vasectomy with prostate... (More)

Purpose Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate cancer. Patients and Methods A total of 84, 753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information on vasectomy status (15% with vasectomy) at recruitment and were followed for incidence of prostate cancer and death. We estimated the association of vasectomy with prostate cancer risk overall, by tumor subtype, and for death due to prostate cancer, using multivariable-adjusted Cox proportional hazards models. Results During an average follow-up of 15.4 years, 4, 377 men were diagnosed with prostate cancer, including 641 who had undergone a vasectomy. Vasectomy was not associated with prostate cancer risk (hazard ratio [HR], 1.05; 95% CI, 0.96 to 1.15), and no evidence for heterogeneity in the association was observed by stage of disease or years since vasectomy. There was some evidence of heterogeneity by tumor grade (P = .02), with an increased risk for low-intermediate grade (HR, 1.14; 95% CI, 1.01 to 1.29) but not high-grade prostate cancer (HR, 0.83; 95% CI, 0.64 to 1.07). Vasectomy was not associated with death due to prostate cancer (HR, 0.88; 95% CI, 0.68 to 1.12). Conclusion These findings from a large European prospective study show no elevated risk for overall, high-grade or advanced-stage prostate cancer, or death due to prostate cancer in men who have undergone a vasectomy compared with men who have not.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Oncology
volume
35
issue
12
pages
1297 - 1303
publisher
American Society of Clinical Oncology
external identifiers
  • scopus:85017653248
  • pmid:28375714
ISSN
0732-183X
DOI
10.1200/JCO.2016.70.0062
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2017 American Society of Clinical Oncology. All rights reserved.
id
cfb1cd77-b582-4ff9-a4bd-6dea4c75f4a6
date added to LUP
2022-12-06 14:12:09
date last changed
2024-05-30 20:19:12
@article{cfb1cd77-b582-4ff9-a4bd-6dea4c75f4a6,
  abstract     = {{<p>Purpose Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate cancer. Patients and Methods A total of 84, 753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information on vasectomy status (15% with vasectomy) at recruitment and were followed for incidence of prostate cancer and death. We estimated the association of vasectomy with prostate cancer risk overall, by tumor subtype, and for death due to prostate cancer, using multivariable-adjusted Cox proportional hazards models. Results During an average follow-up of 15.4 years, 4, 377 men were diagnosed with prostate cancer, including 641 who had undergone a vasectomy. Vasectomy was not associated with prostate cancer risk (hazard ratio [HR], 1.05; 95% CI, 0.96 to 1.15), and no evidence for heterogeneity in the association was observed by stage of disease or years since vasectomy. There was some evidence of heterogeneity by tumor grade (P = .02), with an increased risk for low-intermediate grade (HR, 1.14; 95% CI, 1.01 to 1.29) but not high-grade prostate cancer (HR, 0.83; 95% CI, 0.64 to 1.07). Vasectomy was not associated with death due to prostate cancer (HR, 0.88; 95% CI, 0.68 to 1.12). Conclusion These findings from a large European prospective study show no elevated risk for overall, high-grade or advanced-stage prostate cancer, or death due to prostate cancer in men who have undergone a vasectomy compared with men who have not.</p>}},
  author       = {{Byrne, Karl Smith and Castaño, Jose Maria and Chirlaque, Maria Dolores and Lilja, Hans and Agudo, Antonio and Ardanaz, Eva and Rodríguez-Barranco, Miguel and Boeing, Heiner and Kaaks, Rudolf and Khaw, Kay Tee and Larrañaga, Nerea and Navarro, Carmen and Olsen, Anja and Overvad, Kim and Perez-Cornago, Aurora and Rohrmann, Sabine and Sánchez, Maria José and Tjønneland, Anne and Tsilidis, Konstantinos K. and Johansson, Mattias and Riboli, Elio and Key, Timothy J. and Travis, Ruth C.}},
  issn         = {{0732-183X}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{12}},
  pages        = {{1297--1303}},
  publisher    = {{American Society of Clinical Oncology}},
  series       = {{Journal of Clinical Oncology}},
  title        = {{Vasectomy and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)}},
  url          = {{http://dx.doi.org/10.1200/JCO.2016.70.0062}},
  doi          = {{10.1200/JCO.2016.70.0062}},
  volume       = {{35}},
  year         = {{2017}},
}