Lactational Exposure to Di (2-ethylhexyl) Phthalate Impairs the Ovarian and Uterine Function of Adult Offspring Rat.
(2015) In Reproductive Sciences- Abstract
- Phthalates, a class of chemicals used as plasticizers, are economically important due to several industrial applications. Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used phthalate plasticizer, and it has been described as a potent antiandrogen in males. In this study, lactating dams were exposed via oral gavage to corn oil (vehicle) and DEHP (1, 10, and 100 mg/kg body weight) from postnatal day 1 to 21, and the effects were evaluated in the ovary and uterus of F1 progeny. DEHP exposure significantly decreased the body weight and organ weight in a dose-dependent manner. Serum levels of estradiol, testosterone, and progesterone were decreased but anogenital distance was unaffected. The mRNA expressions of luteinizing hormone... (More)
- Phthalates, a class of chemicals used as plasticizers, are economically important due to several industrial applications. Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used phthalate plasticizer, and it has been described as a potent antiandrogen in males. In this study, lactating dams were exposed via oral gavage to corn oil (vehicle) and DEHP (1, 10, and 100 mg/kg body weight) from postnatal day 1 to 21, and the effects were evaluated in the ovary and uterus of F1 progeny. DEHP exposure significantly decreased the body weight and organ weight in a dose-dependent manner. Serum levels of estradiol, testosterone, and progesterone were decreased but anogenital distance was unaffected. The mRNA expressions of luteinizing hormone receptor, follicle-stimulating hormone receptor, androgen receptor, estrogen receptor (ERα and ERβ), progesterone receptor, peroxisome proliferator-activated receptor γ, 3β hydroxysteroid dehydrogenase, aromatase, and steroidogenic acute regulatory protein were altered in the ovary of F1 progeny rats. Our finding suggest that lactational exposure to DEHP has transgenerational effect on female reproductive system. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8148884
- author
- Somasundaram, Dinesh Babu ; Selvanesan, Benson LU ; Ramachandran, Ilangovan and Bhaskaran, Ravi Sankar
- organization
- publishing date
- 2015-10-19
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Reproductive Sciences
- publisher
- SAGE Publications
- external identifiers
-
- pmid:26482208
- scopus:84961224673
- wos:000374248000017
- pmid:26482208
- ISSN
- 1933-7191
- DOI
- 10.1177/1933719115607995
- language
- English
- LU publication?
- yes
- id
- cfef46c1-2fbc-48f2-8815-ee5a575bde58 (old id 8148884)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26482208?dopt=Abstract
- date added to LUP
- 2016-04-04 07:02:44
- date last changed
- 2022-05-09 00:00:33
@article{cfef46c1-2fbc-48f2-8815-ee5a575bde58,
abstract = {{Phthalates, a class of chemicals used as plasticizers, are economically important due to several industrial applications. Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used phthalate plasticizer, and it has been described as a potent antiandrogen in males. In this study, lactating dams were exposed via oral gavage to corn oil (vehicle) and DEHP (1, 10, and 100 mg/kg body weight) from postnatal day 1 to 21, and the effects were evaluated in the ovary and uterus of F1 progeny. DEHP exposure significantly decreased the body weight and organ weight in a dose-dependent manner. Serum levels of estradiol, testosterone, and progesterone were decreased but anogenital distance was unaffected. The mRNA expressions of luteinizing hormone receptor, follicle-stimulating hormone receptor, androgen receptor, estrogen receptor (ERα and ERβ), progesterone receptor, peroxisome proliferator-activated receptor γ, 3β hydroxysteroid dehydrogenase, aromatase, and steroidogenic acute regulatory protein were altered in the ovary of F1 progeny rats. Our finding suggest that lactational exposure to DEHP has transgenerational effect on female reproductive system.}},
author = {{Somasundaram, Dinesh Babu and Selvanesan, Benson and Ramachandran, Ilangovan and Bhaskaran, Ravi Sankar}},
issn = {{1933-7191}},
language = {{eng}},
month = {{10}},
publisher = {{SAGE Publications}},
series = {{Reproductive Sciences}},
title = {{Lactational Exposure to Di (2-ethylhexyl) Phthalate Impairs the Ovarian and Uterine Function of Adult Offspring Rat.}},
url = {{http://dx.doi.org/10.1177/1933719115607995}},
doi = {{10.1177/1933719115607995}},
year = {{2015}},
}