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CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

Düzel, Emrah ; Berron, David LU ; Schütze, Hartmut ; Cardenas-Blanco, Arturo ; Metzger, Coraline ; Betts, Matthew ; Ziegler, Gabriel ; Chen, Yi ; Dobisch, Laura and Bittner, Daniel , et al. (2018) In Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 10. p.782-790
Abstract

Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age.

Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images.

Results: Total tau levels were specifically and... (More)

Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age.

Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images.

Results: Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ42 levels and novelty responses.

Discussion: Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.

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publishing date
type
Contribution to journal
publication status
published
in
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
volume
10
pages
782 - 790
publisher
Elsevier
external identifiers
  • pmid:30555890
  • scopus:85057812601
ISSN
2352-8729
DOI
10.1016/j.dadm.2018.10.003
language
English
LU publication?
no
id
cff2b4d2-92dd-44ec-930a-845a86661bc3
date added to LUP
2019-05-21 10:12:36
date last changed
2021-05-05 04:06:27
@article{cff2b4d2-92dd-44ec-930a-845a86661bc3,
  abstract     = {<p>Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age.</p><p>Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images.</p><p>Results: Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ42 levels and novelty responses.</p><p>Discussion: Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.</p>},
  author       = {Düzel, Emrah and Berron, David and Schütze, Hartmut and Cardenas-Blanco, Arturo and Metzger, Coraline and Betts, Matthew and Ziegler, Gabriel and Chen, Yi and Dobisch, Laura and Bittner, Daniel and Glanz, Wenzel and Reuter, Martin and Spottke, Annika and Rudolph, Janna and Brosseron, Frederic and Buerger, Katharina and Janowitz, Daniel and Fliessbach, Klaus and Heneka, Michael and Laske, Christoph and Buchmann, Martina and Nestor, Peter and Peters, Oliver and Diesing, Dominik and Li, Siyao and Priller, Josef and Spruth, Eike Jakob and Altenstein, Slawek and Ramirez, Alfredo and Schneider, Anja and Kofler, Barbara and Speck, Oliver and Teipel, Stefan and Kilimann, Ingo and Dyrba, Martin and Wiltfang, Jens and Bartels, Claudia and Wolfsgruber, Steffen and Wagner, Michael and Jessen, Frank},
  issn         = {2352-8729},
  language     = {eng},
  pages        = {782--790},
  publisher    = {Elsevier},
  series       = {Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring},
  title        = {CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume},
  url          = {http://dx.doi.org/10.1016/j.dadm.2018.10.003},
  doi          = {10.1016/j.dadm.2018.10.003},
  volume       = {10},
  year         = {2018},
}