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The Association of Mitochondrial Content with Prevalent and Incident Type 2 Diabetes.

Reiling, Erwin LU ; Ling, Charlotte LU orcid ; Uitterlinden, André G ; Van't Riet, Esther ; Welschen, Laura M C ; Ladenvall, Claes LU ; Almgren, Peter LU ; Lyssenko, Valeriya ; Nijpels, Giel and van Hove, Els C , et al. (2010) In The Journal of clinical endocrinology and metabolism 95. p.1909-1915
Abstract
Context: It has been shown that mitochondrial DNA (mtDNA) content is associated with type 2 diabetes (T2D) and related traits. However, empirical data, often based on small samples, did not confirm this observation in all studies. Therefore, the role of mtDNA content in T2D remains elusive. Objective: In this study, we assessed the heritability of mtDNA content in buccal cells and analyzed the association of mtDNA content in blood with prevalent and incident T2D. Design and Setting: mtDNA content from cells from buccal and blood samples was assessed using a real-time PCR-based assay. Heritability of mtDNA content was estimated in 391 twins from the Netherlands Twin Register. The association with prevalent T2D was tested in a case control... (More)
Context: It has been shown that mitochondrial DNA (mtDNA) content is associated with type 2 diabetes (T2D) and related traits. However, empirical data, often based on small samples, did not confirm this observation in all studies. Therefore, the role of mtDNA content in T2D remains elusive. Objective: In this study, we assessed the heritability of mtDNA content in buccal cells and analyzed the association of mtDNA content in blood with prevalent and incident T2D. Design and Setting: mtDNA content from cells from buccal and blood samples was assessed using a real-time PCR-based assay. Heritability of mtDNA content was estimated in 391 twins from the Netherlands Twin Register. The association with prevalent T2D was tested in a case control study from The Netherlands (n = 329). Incident T2D was analyzed using prospective samples from Finland (n = 444) and The Netherlands (n = 238). Main Outcome Measures: We measured the heritability of mtDNA content and the association of mtDNA content in blood with prevalent and incident T2D. Results: A heritability of mtDNA content of 35% (19-48%) was estimated in the twin families. We did not observe evidence of an association between mtDNA content and prevalent or incident T2D and related traits. Furthermore, we observed a decline in mtDNA content with increasing age that was male specific (P = 0.001). Conclusion: In this study, we show that mtDNA content has a heritability of 35% in Dutch twins. There is no association between mtDNA content in blood and prevalent or incident T2D and related traits in our study samples. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of clinical endocrinology and metabolism
volume
95
pages
1909 - 1915
publisher
Oxford University Press
external identifiers
  • wos:000276402300052
  • pmid:20150578
  • scopus:77951635228
ISSN
1945-7197
DOI
10.1210/jc.2009-1775
language
English
LU publication?
yes
id
d005217c-3ca6-4e17-97fb-aa33035aef3e (old id 1552691)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20150578?dopt=Abstract
date added to LUP
2016-04-04 09:21:01
date last changed
2022-09-21 18:13:13
@article{d005217c-3ca6-4e17-97fb-aa33035aef3e,
  abstract     = {{Context: It has been shown that mitochondrial DNA (mtDNA) content is associated with type 2 diabetes (T2D) and related traits. However, empirical data, often based on small samples, did not confirm this observation in all studies. Therefore, the role of mtDNA content in T2D remains elusive. Objective: In this study, we assessed the heritability of mtDNA content in buccal cells and analyzed the association of mtDNA content in blood with prevalent and incident T2D. Design and Setting: mtDNA content from cells from buccal and blood samples was assessed using a real-time PCR-based assay. Heritability of mtDNA content was estimated in 391 twins from the Netherlands Twin Register. The association with prevalent T2D was tested in a case control study from The Netherlands (n = 329). Incident T2D was analyzed using prospective samples from Finland (n = 444) and The Netherlands (n = 238). Main Outcome Measures: We measured the heritability of mtDNA content and the association of mtDNA content in blood with prevalent and incident T2D. Results: A heritability of mtDNA content of 35% (19-48%) was estimated in the twin families. We did not observe evidence of an association between mtDNA content and prevalent or incident T2D and related traits. Furthermore, we observed a decline in mtDNA content with increasing age that was male specific (P = 0.001). Conclusion: In this study, we show that mtDNA content has a heritability of 35% in Dutch twins. There is no association between mtDNA content in blood and prevalent or incident T2D and related traits in our study samples.}},
  author       = {{Reiling, Erwin and Ling, Charlotte and Uitterlinden, André G and Van't Riet, Esther and Welschen, Laura M C and Ladenvall, Claes and Almgren, Peter and Lyssenko, Valeriya and Nijpels, Giel and van Hove, Els C and Maassen, Johannes A and de Geus, Eco J C and Boomsma, Dorret I and Dekker, Jacqueline M and Groop, Leif and Willemsen, Gonneke and 't Hart, Leen M}},
  issn         = {{1945-7197}},
  language     = {{eng}},
  pages        = {{1909--1915}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of clinical endocrinology and metabolism}},
  title        = {{The Association of Mitochondrial Content with Prevalent and Incident Type 2 Diabetes.}},
  url          = {{http://dx.doi.org/10.1210/jc.2009-1775}},
  doi          = {{10.1210/jc.2009-1775}},
  volume       = {{95}},
  year         = {{2010}},
}