Drug Release and Skin Permeation from Lipid Liquid Crystalline Phases
(2008) 9th International Conference on Colloid Chemistry, 1997 135. p.119-129- Abstract
- We have studied drug release and skin permeation from several different liquid crystalline lipid formulations that may be used to control the respective release rates. We have studied the release and permeation through human skin of a water-soluble and amphiphilic drug, propranolol hydrochloride, from several formulations prepared with monoolein and phytantriol as permeation enhancers and controlled release excipients. Diolein and cineol were added to selected formulations. We observed that viscosity decreases with drug load, wich is compatible with the occurrence of phase changes. Diolein stabilizes the bicontinuous cubic phases leading to an increase in viscosity and sustained release of the drug. The slowest release was found for the... (More)
- We have studied drug release and skin permeation from several different liquid crystalline lipid formulations that may be used to control the respective release rates. We have studied the release and permeation through human skin of a water-soluble and amphiphilic drug, propranolol hydrochloride, from several formulations prepared with monoolein and phytantriol as permeation enhancers and controlled release excipients. Diolein and cineol were added to selected formulations. We observed that viscosity decreases with drug load, wich is compatible with the occurrence of phase changes. Diolein stabilizes the bicontinuous cubic phases leading to an increase in viscosity and sustained release of the drug. The slowest release was found for the cubic phases with higher viscosity. Studies on skin permeation showed that these latter formulations also presented lower permeability than the less viscous monoolein lamellar phases. Formulations containing cineol originated higher permeability with higher enhancement ratios. Thus, the various formulations are adapted to different circumstances and delivery routes. While a slow release is usually desired for drug sustained delivery, the transdermal route may require a faster release. Lamellar phases, which are less viscous, are more adapted to transdermal applications. Thus, systems involving lamellar phases of monoolein and cineol are good candidates to be used as skin permeation enhancers for propranolol hydrochloride. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1399350
- author
- Costa, Fatima LU ; Sparr, Emma LU ; Sousa, J. J. S. and Pais, A. A. C. C.
- organization
- publishing date
- 2008
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Phytantriol, Monoolein, Lipid liquid crystalline phases, Drug release, Enhancers, Propranolol hydrochloride, Skin permeation
- host publication
- Colloids for Nano- and Biotechnology (Progress in Colloid and Polymer Science)
- volume
- 135
- pages
- 119 - 129
- publisher
- Springer
- conference name
- 9th International Conference on Colloid Chemistry, 1997
- conference location
- Siofok, Hungary
- conference dates
- 1997-07-06 - 1997-07-12
- external identifiers
-
- wos:000264002200017
- scopus:62449306644
- ISSN
- 0340-255X
- ISBN
- 978-3-540-85133-2
- DOI
- 10.1007/2882_2008_097
- language
- English
- LU publication?
- yes
- id
- d00ec8b8-62ee-4778-8379-305fc6feee0d (old id 1399350)
- date added to LUP
- 2016-04-01 14:54:04
- date last changed
- 2022-01-28 03:04:31
@inproceedings{d00ec8b8-62ee-4778-8379-305fc6feee0d,
abstract = {{We have studied drug release and skin permeation from several different liquid crystalline lipid formulations that may be used to control the respective release rates. We have studied the release and permeation through human skin of a water-soluble and amphiphilic drug, propranolol hydrochloride, from several formulations prepared with monoolein and phytantriol as permeation enhancers and controlled release excipients. Diolein and cineol were added to selected formulations. We observed that viscosity decreases with drug load, wich is compatible with the occurrence of phase changes. Diolein stabilizes the bicontinuous cubic phases leading to an increase in viscosity and sustained release of the drug. The slowest release was found for the cubic phases with higher viscosity. Studies on skin permeation showed that these latter formulations also presented lower permeability than the less viscous monoolein lamellar phases. Formulations containing cineol originated higher permeability with higher enhancement ratios. Thus, the various formulations are adapted to different circumstances and delivery routes. While a slow release is usually desired for drug sustained delivery, the transdermal route may require a faster release. Lamellar phases, which are less viscous, are more adapted to transdermal applications. Thus, systems involving lamellar phases of monoolein and cineol are good candidates to be used as skin permeation enhancers for propranolol hydrochloride.}},
author = {{Costa, Fatima and Sparr, Emma and Sousa, J. J. S. and Pais, A. A. C. C.}},
booktitle = {{Colloids for Nano- and Biotechnology (Progress in Colloid and Polymer Science)}},
isbn = {{978-3-540-85133-2}},
issn = {{0340-255X}},
keywords = {{Phytantriol; Monoolein; Lipid liquid crystalline phases; Drug release; Enhancers; Propranolol hydrochloride; Skin permeation}},
language = {{eng}},
pages = {{119--129}},
publisher = {{Springer}},
title = {{Drug Release and Skin Permeation from Lipid Liquid Crystalline Phases}},
url = {{http://dx.doi.org/10.1007/2882_2008_097}},
doi = {{10.1007/2882_2008_097}},
volume = {{135}},
year = {{2008}},
}