Interleukin-1β regulation of islet and thyroid autoimmunity in the BB rat
Vertrees, Sarah ; Wilson, Cindy A. ; Ubungen, Roel ; Wilson, Deborah ; Baskin, Denis G. ; Toivola, Bert ; Jacobs, Cindy ; Boiani, Norman ; Baker, Paul and Lernmark, Åke LU
(1991)
In Journal of Autoimmunity
4(5).
p.717-732
- Abstract
Daily injections of high dose human recombinant interleukin-1β (IL-1β) accelerated the onset of both insulin-dependent diabetes mellitus and lymphocytic thyroiditis in genetically prone BB rats. In diabetes-resistant BB rats, high dose IL-1β failed to induce diabetes. Additionally, the presence of neutralizing IL-1β antibodies in these rats strongly correlated with inhibition of lymphocytic thyroiditis. Since low dose IL-1β protects diabetes-prone rats from IDDM, we conclude that IL-1β is a potent modulator of autoimmune diabetes and thyroid disease in genetically susceptible rats.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/d0173264-501a-4a70-9d7c-75bb18a63747
- author
- Vertrees, Sarah
; Wilson, Cindy A.
; Ubungen, Roel
; Wilson, Deborah
; Baskin, Denis G.
; Toivola, Bert
; Jacobs, Cindy
; Boiani, Norman
; Baker, Paul
and Lernmark, Åke
LU
- publishing date
- 1991-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Journal of Autoimmunity
- volume
- 4
- issue
- 5
- pages
- 16 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0026006222
- pmid:1797022
- ISSN
- 0896-8411
- DOI
- 10.1016/0896-8411(91)90168-C
- language
- English
- LU publication?
- no
- id
- d0173264-501a-4a70-9d7c-75bb18a63747
- date added to LUP
- 2019-09-11 09:36:55
- date last changed
- 2024-03-13 08:15:30
@article{d0173264-501a-4a70-9d7c-75bb18a63747,
abstract = {{<p>Daily injections of high dose human recombinant interleukin-1β (IL-1β) accelerated the onset of both insulin-dependent diabetes mellitus and lymphocytic thyroiditis in genetically prone BB rats. In diabetes-resistant BB rats, high dose IL-1β failed to induce diabetes. Additionally, the presence of neutralizing IL-1β antibodies in these rats strongly correlated with inhibition of lymphocytic thyroiditis. Since low dose IL-1β protects diabetes-prone rats from IDDM, we conclude that IL-1β is a potent modulator of autoimmune diabetes and thyroid disease in genetically susceptible rats.</p>}},
author = {{Vertrees, Sarah and Wilson, Cindy A. and Ubungen, Roel and Wilson, Deborah and Baskin, Denis G. and Toivola, Bert and Jacobs, Cindy and Boiani, Norman and Baker, Paul and Lernmark, Åke}},
issn = {{0896-8411}},
language = {{eng}},
month = {{01}},
number = {{5}},
pages = {{717--732}},
publisher = {{Elsevier}},
series = {{Journal of Autoimmunity}},
title = {{Interleukin-1β regulation of islet and thyroid autoimmunity in the BB rat}},
url = {{http://dx.doi.org/10.1016/0896-8411(91)90168-C}},
doi = {{10.1016/0896-8411(91)90168-C}},
volume = {{4}},
year = {{1991}},
}