In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals
Das, Sandhitsu R ; Xie, Long ; Wisse, Laura E M LU
; Vergnet, Nicolas
; Ittyerah, Ranjit
; Cui, Salena
; Yushkevich, Paul A
and Wolk, David A
(2019)
In Alzheimer's & dementia : the journal of the Alzheimer's Association
15(10).
p.1286-1295
- Abstract
INTRODUCTION: It is unclear the degree to which tau pathology in the medial temporal lobe (MTL) measured by 18F-flortaucipir positron emission tomography relates to MTL subregional atrophy and whether this relationship differs between amyloid-β-positive and amyloid-β-negative individuals.
METHODS: We analyzed correlation of MTL 18F-flortaucipir uptake with MTL subregional atrophy measured with high-resolution magnetic resonance imaging in a region of interest and regional thickness analysis and determined the relationship between memory performance and positron emission tomography and magnetic resonance imaging measures.
RESULTS: Both groups showed strong correlations between 18F-flortaucipir uptake and atrophy, with similar... (More)
INTRODUCTION: It is unclear the degree to which tau pathology in the medial temporal lobe (MTL) measured by 18F-flortaucipir positron emission tomography relates to MTL subregional atrophy and whether this relationship differs between amyloid-β-positive and amyloid-β-negative individuals.
METHODS: We analyzed correlation of MTL 18F-flortaucipir uptake with MTL subregional atrophy measured with high-resolution magnetic resonance imaging in a region of interest and regional thickness analysis and determined the relationship between memory performance and positron emission tomography and magnetic resonance imaging measures.
RESULTS: Both groups showed strong correlations between 18F-flortaucipir uptake and atrophy, with similar spatial patterns. Effects in the rhinal cortex recapitulated Braak staging. Correlations of memory recall with atrophy and tracer uptake were observed.
DISCUSSION: Correlation patterns between tau burden and atrophy in the amyloid-β-negative group mimicking early Braak stages suggests that 18F-flortaucipir is sensitive to tau pathology in primary age-related tauopathy. Correlations of imaging measures with memory performance indicate that this pathology is associated with poorer cognition.
(Less)
- author
- Das, Sandhitsu R
; Xie, Long
; Wisse, Laura E M
LU
; Vergnet, Nicolas
; Ittyerah, Ranjit
; Cui, Salena
; Yushkevich, Paul A
and Wolk, David A
- author collaboration
- publishing date
- 2019-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Alzheimer Disease/diagnostic imaging, Amyloid/metabolism, Atrophy/metabolism, Carbolines, Cognitive Dysfunction/diagnostic imaging, Female, Humans, Magnetic Resonance Imaging, Male, Memory/physiology, Neuropsychological Tests/statistics & numerical data, Positron-Emission Tomography, Tauopathies/metabolism, Temporal Lobe/metabolism, tau Proteins/metabolism
- in
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- volume
- 15
- issue
- 10
- pages
- 1286 - 1295
- publisher
- Wiley
- external identifiers
-
- scopus:85071867391
- pmid:31495603
- ISSN
- 1552-5279
- DOI
- 10.1016/j.jalz.2019.05.009
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
- id
- d01b25fa-d507-4122-bb55-105804009883
- date added to LUP
- 2024-02-28 14:41:16
- date last changed
- 2024-04-14 02:05:34
@article{d01b25fa-d507-4122-bb55-105804009883,
abstract = {{<p>INTRODUCTION: It is unclear the degree to which tau pathology in the medial temporal lobe (MTL) measured by 18F-flortaucipir positron emission tomography relates to MTL subregional atrophy and whether this relationship differs between amyloid-β-positive and amyloid-β-negative individuals.</p><p>METHODS: We analyzed correlation of MTL 18F-flortaucipir uptake with MTL subregional atrophy measured with high-resolution magnetic resonance imaging in a region of interest and regional thickness analysis and determined the relationship between memory performance and positron emission tomography and magnetic resonance imaging measures.</p><p>RESULTS: Both groups showed strong correlations between 18F-flortaucipir uptake and atrophy, with similar spatial patterns. Effects in the rhinal cortex recapitulated Braak staging. Correlations of memory recall with atrophy and tracer uptake were observed.</p><p>DISCUSSION: Correlation patterns between tau burden and atrophy in the amyloid-β-negative group mimicking early Braak stages suggests that 18F-flortaucipir is sensitive to tau pathology in primary age-related tauopathy. Correlations of imaging measures with memory performance indicate that this pathology is associated with poorer cognition.</p>}},
author = {{Das, Sandhitsu R and Xie, Long and Wisse, Laura E M and Vergnet, Nicolas and Ittyerah, Ranjit and Cui, Salena and Yushkevich, Paul A and Wolk, David A}},
issn = {{1552-5279}},
keywords = {{Aged; Alzheimer Disease/diagnostic imaging; Amyloid/metabolism; Atrophy/metabolism; Carbolines; Cognitive Dysfunction/diagnostic imaging; Female; Humans; Magnetic Resonance Imaging; Male; Memory/physiology; Neuropsychological Tests/statistics & numerical data; Positron-Emission Tomography; Tauopathies/metabolism; Temporal Lobe/metabolism; tau Proteins/metabolism}},
language = {{eng}},
number = {{10}},
pages = {{1286--1295}},
publisher = {{Wiley}},
series = {{Alzheimer's & dementia : the journal of the Alzheimer's Association}},
title = {{In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals}},
url = {{http://dx.doi.org/10.1016/j.jalz.2019.05.009}},
doi = {{10.1016/j.jalz.2019.05.009}},
volume = {{15}},
year = {{2019}},
}