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The Evolving Future of Instantaneous Wave-Free Ratio and Fractional Flow Reserve

Götberg, Matthias LU ; Cook, Christopher M.; Sen, Sayan; Nijjer, Sukhjinder; Escaned, Javier and Davies, Justin E. (2017) In Journal of the American College of Cardiology 70(11). p.1379-1402
Abstract

In this review, the authors reflect upon the role of coronary physiology in the modern management of coronary artery disease. They critically appraise the scientific background of the instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR), from early experimental studies to validation studies against indexes of ischemia, to clinical trials assessing outcome. At this important juncture for the field, the authors make predictions for the future of physiological stenosis assessment, outlining developments for both iFR and FFR in new clinical domains beyond the confines of stable angina. With a focus on the evolving future of iFR and FFR, the authors describe how physiological assessment with iFR may advance its application... (More)

In this review, the authors reflect upon the role of coronary physiology in the modern management of coronary artery disease. They critically appraise the scientific background of the instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR), from early experimental studies to validation studies against indexes of ischemia, to clinical trials assessing outcome. At this important juncture for the field, the authors make predictions for the future of physiological stenosis assessment, outlining developments for both iFR and FFR in new clinical domains beyond the confines of stable angina. With a focus on the evolving future of iFR and FFR, the authors describe how physiological assessment with iFR may advance its application from simply justifying to guiding revascularization.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary artery bypass graft, coronary physiology, coronary stenosis, myocardial revascularization, percutaneous coronary intervention
in
Journal of the American College of Cardiology
volume
70
issue
11
pages
24 pages
publisher
Elsevier USA
external identifiers
  • scopus:85029496199
  • wos:000409102100011
ISSN
0735-1097
DOI
10.1016/j.jacc.2017.07.770
language
English
LU publication?
yes
id
d084db4b-a062-4623-8f25-362e07ce0c11
date added to LUP
2017-10-09 09:23:42
date last changed
2018-10-14 04:43:27
@article{d084db4b-a062-4623-8f25-362e07ce0c11,
  abstract     = {<p>In this review, the authors reflect upon the role of coronary physiology in the modern management of coronary artery disease. They critically appraise the scientific background of the instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR), from early experimental studies to validation studies against indexes of ischemia, to clinical trials assessing outcome. At this important juncture for the field, the authors make predictions for the future of physiological stenosis assessment, outlining developments for both iFR and FFR in new clinical domains beyond the confines of stable angina. With a focus on the evolving future of iFR and FFR, the authors describe how physiological assessment with iFR may advance its application from simply justifying to guiding revascularization.</p>},
  author       = {Götberg, Matthias and Cook, Christopher M. and Sen, Sayan and Nijjer, Sukhjinder and Escaned, Javier and Davies, Justin E.},
  issn         = {0735-1097},
  keyword      = {coronary artery bypass graft,coronary physiology,coronary stenosis,myocardial revascularization,percutaneous coronary intervention},
  language     = {eng},
  month        = {09},
  number       = {11},
  pages        = {1379--1402},
  publisher    = {Elsevier USA},
  series       = {Journal of the American College of Cardiology},
  title        = {The Evolving Future of Instantaneous Wave-Free Ratio and Fractional Flow Reserve},
  url          = {http://dx.doi.org/10.1016/j.jacc.2017.07.770},
  volume       = {70},
  year         = {2017},
}