The Evolving Future of Instantaneous Wave-Free Ratio and Fractional Flow Reserve
(2017) In Journal of the American College of Cardiology 70(11). p.1379-1402- Abstract
In this review, the authors reflect upon the role of coronary physiology in the modern management of coronary artery disease. They critically appraise the scientific background of the instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR), from early experimental studies to validation studies against indexes of ischemia, to clinical trials assessing outcome. At this important juncture for the field, the authors make predictions for the future of physiological stenosis assessment, outlining developments for both iFR and FFR in new clinical domains beyond the confines of stable angina. With a focus on the evolving future of iFR and FFR, the authors describe how physiological assessment with iFR may advance its application... (More)
In this review, the authors reflect upon the role of coronary physiology in the modern management of coronary artery disease. They critically appraise the scientific background of the instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR), from early experimental studies to validation studies against indexes of ischemia, to clinical trials assessing outcome. At this important juncture for the field, the authors make predictions for the future of physiological stenosis assessment, outlining developments for both iFR and FFR in new clinical domains beyond the confines of stable angina. With a focus on the evolving future of iFR and FFR, the authors describe how physiological assessment with iFR may advance its application from simply justifying to guiding revascularization.
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- author
- Götberg, Matthias LU ; Cook, Christopher M. ; Sen, Sayan ; Nijjer, Sukhjinder ; Escaned, Javier and Davies, Justin E.
- organization
- publishing date
- 2017-09-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- coronary artery bypass graft, coronary physiology, coronary stenosis, myocardial revascularization, percutaneous coronary intervention
- in
- Journal of the American College of Cardiology
- volume
- 70
- issue
- 11
- pages
- 24 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:28882237
- wos:000409102100011
- scopus:85029496199
- ISSN
- 0735-1097
- DOI
- 10.1016/j.jacc.2017.07.770
- language
- English
- LU publication?
- yes
- id
- d084db4b-a062-4623-8f25-362e07ce0c11
- date added to LUP
- 2017-10-09 09:23:42
- date last changed
- 2025-04-16 11:50:25
@article{d084db4b-a062-4623-8f25-362e07ce0c11,
abstract = {{<p>In this review, the authors reflect upon the role of coronary physiology in the modern management of coronary artery disease. They critically appraise the scientific background of the instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR), from early experimental studies to validation studies against indexes of ischemia, to clinical trials assessing outcome. At this important juncture for the field, the authors make predictions for the future of physiological stenosis assessment, outlining developments for both iFR and FFR in new clinical domains beyond the confines of stable angina. With a focus on the evolving future of iFR and FFR, the authors describe how physiological assessment with iFR may advance its application from simply justifying to guiding revascularization.</p>}},
author = {{Götberg, Matthias and Cook, Christopher M. and Sen, Sayan and Nijjer, Sukhjinder and Escaned, Javier and Davies, Justin E.}},
issn = {{0735-1097}},
keywords = {{coronary artery bypass graft; coronary physiology; coronary stenosis; myocardial revascularization; percutaneous coronary intervention}},
language = {{eng}},
month = {{09}},
number = {{11}},
pages = {{1379--1402}},
publisher = {{Elsevier}},
series = {{Journal of the American College of Cardiology}},
title = {{The Evolving Future of Instantaneous Wave-Free Ratio and Fractional Flow Reserve}},
url = {{http://dx.doi.org/10.1016/j.jacc.2017.07.770}},
doi = {{10.1016/j.jacc.2017.07.770}},
volume = {{70}},
year = {{2017}},
}