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Maternal hypertensive disorders of pregnancy and offspring risk of hypertension : a population-based cohort and sibling study

Kurbasic, Azra LU ; Fraser, Abigail ; Mogren, Ingrid ; Hallmans, Göran ; Franks, Paul W LU ; Rich-Edwards, Janet W and Timpka, Simon LU (2019) In American Journal of Hypertension 32(4). p.331-334
Abstract

BACKGROUND: Women with a history of hypertensive disorders of pregnancy (HDP) are at increased risk of hypertension, cardiovascular disease, and type 2 diabetes. Offspring from pregnancies complicated by HDP also have worse cardiometabolic status in childhood and young adulthood, but the offspring risk of clinical hypertension in adulthood is largely unknown.

METHODS: We studied 13,893 first-born adult offspring (49.4% female) who attended a structured population-based primary care visit (The Västerbotten Health Survey) at age 40 years in Sweden between 1994 and 2013. Data on maternal HDP were collected from a population-based birth register. We investigated the association between maternal HDP and the risk of adult offspring... (More)

BACKGROUND: Women with a history of hypertensive disorders of pregnancy (HDP) are at increased risk of hypertension, cardiovascular disease, and type 2 diabetes. Offspring from pregnancies complicated by HDP also have worse cardiometabolic status in childhood and young adulthood, but the offspring risk of clinical hypertension in adulthood is largely unknown.

METHODS: We studied 13,893 first-born adult offspring (49.4% female) who attended a structured population-based primary care visit (The Västerbotten Health Survey) at age 40 years in Sweden between 1994 and 2013. Data on maternal HDP were collected from a population-based birth register. We investigated the association between maternal HDP and the risk of adult offspring hypertension and worse cardiometabolic risk factor status utilizing multivariable log binomial and linear regression models. We also conducted a sibling comparison, which inherently accounted for familial factors shared by siblings (N=135).

RESULTS: Offspring participants of women with HDP (N=383, 2.8%) had increased relative risk of hypertension (1.67, 95% confidence interval: 1.38, 2.01) and also higher mean body mass index, systolic blood pressure, diastolic blood pressure, and worse 2h 75g oral glucose tolerance test result at age 40 years. No difference was observed for serum cholesterol. Point estimates for the cardiometabolic risk factors were attenuated in the sibling analyses.

CONCLUSION: Offspring born to mothers with a history of HDP are on an adverse cardiometabolic trajectory, and should be considered as concomitant targets for primordial prevention of hypertension in the maternal post-pregnancy period.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Hypertension
volume
32
issue
4
pages
331 - 334
publisher
Elsevier
external identifiers
  • pmid:30475953
  • scopus:85062985965
ISSN
1941-7225
DOI
10.1093/ajh/hpy176
language
English
LU publication?
yes
id
d0854717-5d68-48a0-9ca4-52b58271a8b7
date added to LUP
2018-12-03 21:33:38
date last changed
2020-01-13 01:14:41
@article{d0854717-5d68-48a0-9ca4-52b58271a8b7,
  abstract     = {<p>BACKGROUND: Women with a history of hypertensive disorders of pregnancy (HDP) are at increased risk of hypertension, cardiovascular disease, and type 2 diabetes. Offspring from pregnancies complicated by HDP also have worse cardiometabolic status in childhood and young adulthood, but the offspring risk of clinical hypertension in adulthood is largely unknown.</p><p>METHODS: We studied 13,893 first-born adult offspring (49.4% female) who attended a structured population-based primary care visit (The Västerbotten Health Survey) at age 40 years in Sweden between 1994 and 2013. Data on maternal HDP were collected from a population-based birth register. We investigated the association between maternal HDP and the risk of adult offspring hypertension and worse cardiometabolic risk factor status utilizing multivariable log binomial and linear regression models. We also conducted a sibling comparison, which inherently accounted for familial factors shared by siblings (N=135).</p><p>RESULTS: Offspring participants of women with HDP (N=383, 2.8%) had increased relative risk of hypertension (1.67, 95% confidence interval: 1.38, 2.01) and also higher mean body mass index, systolic blood pressure, diastolic blood pressure, and worse 2h 75g oral glucose tolerance test result at age 40 years. No difference was observed for serum cholesterol. Point estimates for the cardiometabolic risk factors were attenuated in the sibling analyses.</p><p>CONCLUSION: Offspring born to mothers with a history of HDP are on an adverse cardiometabolic trajectory, and should be considered as concomitant targets for primordial prevention of hypertension in the maternal post-pregnancy period.</p>},
  author       = {Kurbasic, Azra and Fraser, Abigail and Mogren, Ingrid and Hallmans, Göran and Franks, Paul W and Rich-Edwards, Janet W and Timpka, Simon},
  issn         = {1941-7225},
  language     = {eng},
  number       = {4},
  pages        = {331--334},
  publisher    = {Elsevier},
  series       = {American Journal of Hypertension},
  title        = {Maternal hypertensive disorders of pregnancy and offspring risk of hypertension : a population-based cohort and sibling study},
  url          = {http://dx.doi.org/10.1093/ajh/hpy176},
  doi          = {10.1093/ajh/hpy176},
  volume       = {32},
  year         = {2019},
}