Impaired odor recognition memory in Parkinson's disease linked to absent functional hippocampal asymmetry
Eek, Tom ; Bolton, Thomas A W ; Dizdar, Nil ; Larsson, Maria ; Lundin, Fredrik and Georgiopoulos, Charalampos LU
(2025)
In npj Parkinson's Disease
11.
p.1-7
- Abstract
Odor recognition memory (ORM) combines olfaction and episodic memory, both linked to dementia and impaired in Parkinson's Disease (PD). Measuring ORM may indicate early PD dementia and aid in selecting device-aided Parkinson therapy. This study investigates ORM capacity and hippocampal dynamic functional connectivity in PD. Thirty-one PD participants and 31 healthy controls (HC) underwent functional MRI during an ORM task. Co-activation pattern analysis identified active hippocampal networks. The PD group showed impaired ORM and a sequence of four activated hippocampal networks. The fourth network, involving the dorsal Attention Network (dAN), had fewer and shorter expressions during correct ORM responses in PD compared with HC.... (More)
Odor recognition memory (ORM) combines olfaction and episodic memory, both linked to dementia and impaired in Parkinson's Disease (PD). Measuring ORM may indicate early PD dementia and aid in selecting device-aided Parkinson therapy. This study investigates ORM capacity and hippocampal dynamic functional connectivity in PD. Thirty-one PD participants and 31 healthy controls (HC) underwent functional MRI during an ORM task. Co-activation pattern analysis identified active hippocampal networks. The PD group showed impaired ORM and a sequence of four activated hippocampal networks. The fourth network, involving the dorsal Attention Network (dAN), had fewer and shorter expressions during correct ORM responses in PD compared with HC. Hippocampal functional asymmetry was observed in HC but not in PD. These findings suggest that impaired ORM in PD is linked to reduced hippocampal functional asymmetry. Future research should explore differences in functional dynamics of odor memory-related brain regions in PD patients with and without cognitive decline.
(Less)
- author
- Eek, Tom
; Bolton, Thomas A W
; Dizdar, Nil
; Larsson, Maria
; Lundin, Fredrik
and Georgiopoulos, Charalampos
LU
- organization
- publishing date
- 2025-03-23
- type
- Contribution to journal
- publication status
- published
- subject
- in
- npj Parkinson's Disease
- volume
- 11
- article number
- 56
- pages
- 1 - 7
- publisher
- Springer Nature
- external identifiers
-
- scopus:105000866934
- pmid:40122891
- ISSN
- 2373-8057
- DOI
- 10.1038/s41531-025-00906-3
- language
- English
- LU publication?
- yes
- additional info
- © 2025. The Author(s).
- id
- d08d2b76-be7c-4eb3-b15f-1530eaef6636
- date added to LUP
- 2025-10-10 10:44:51
- date last changed
- 2025-10-11 04:01:18
@article{d08d2b76-be7c-4eb3-b15f-1530eaef6636,
abstract = {{<p>Odor recognition memory (ORM) combines olfaction and episodic memory, both linked to dementia and impaired in Parkinson's Disease (PD). Measuring ORM may indicate early PD dementia and aid in selecting device-aided Parkinson therapy. This study investigates ORM capacity and hippocampal dynamic functional connectivity in PD. Thirty-one PD participants and 31 healthy controls (HC) underwent functional MRI during an ORM task. Co-activation pattern analysis identified active hippocampal networks. The PD group showed impaired ORM and a sequence of four activated hippocampal networks. The fourth network, involving the dorsal Attention Network (dAN), had fewer and shorter expressions during correct ORM responses in PD compared with HC. Hippocampal functional asymmetry was observed in HC but not in PD. These findings suggest that impaired ORM in PD is linked to reduced hippocampal functional asymmetry. Future research should explore differences in functional dynamics of odor memory-related brain regions in PD patients with and without cognitive decline.</p>}},
author = {{Eek, Tom and Bolton, Thomas A W and Dizdar, Nil and Larsson, Maria and Lundin, Fredrik and Georgiopoulos, Charalampos}},
issn = {{2373-8057}},
language = {{eng}},
month = {{03}},
pages = {{1--7}},
publisher = {{Springer Nature}},
series = {{npj Parkinson's Disease}},
title = {{Impaired odor recognition memory in Parkinson's disease linked to absent functional hippocampal asymmetry}},
url = {{http://dx.doi.org/10.1038/s41531-025-00906-3}},
doi = {{10.1038/s41531-025-00906-3}},
volume = {{11}},
year = {{2025}},
}