Whole-body cooling increases plasma endothelin-1 levels in women with primary Raynaud's phenomenon
(1998) In Clinical Physiology and Functional Imaging 18(5). p.5-420- Abstract
To understand better the role of endothelin-1 (ET-1) in the pathogenesis of primary Raynaud's phenomenon (PRP), we investigated the basal ET-1 plasma levels and changes after whole-body cooling in healthy women and those with PRP. The study was performed as an open parallel-group comparison during the month of February. The Raynaud group included 21 female patients (mean age 45.3 years, range 21-57 years) who had had disabling Raynaud's phenomenon for a mean period of 17 years (range 2-26 years). The control group consisted of 25 healthy women (mean age 43.6 years, range 27-56 years). Plasma levels of ET-1 were measured on two separate occasions: once after 30 min of rest at room temperature and after 40 min of whole-body cooling. There... (More)
To understand better the role of endothelin-1 (ET-1) in the pathogenesis of primary Raynaud's phenomenon (PRP), we investigated the basal ET-1 plasma levels and changes after whole-body cooling in healthy women and those with PRP. The study was performed as an open parallel-group comparison during the month of February. The Raynaud group included 21 female patients (mean age 45.3 years, range 21-57 years) who had had disabling Raynaud's phenomenon for a mean period of 17 years (range 2-26 years). The control group consisted of 25 healthy women (mean age 43.6 years, range 27-56 years). Plasma levels of ET-1 were measured on two separate occasions: once after 30 min of rest at room temperature and after 40 min of whole-body cooling. There were no significant differences in baseline plasma ET-1 levels between the two groups of women. The plasma ET-1 levels increased significantly in the PRP group after cold exposure (mean difference 0.11 pmol l-1, 95% CI 0.005-0.214, P = 0.012). In contrast, the levels of plasma ET-1 in the control group did not change significantly after cold provocation. In conclusion, no differences in plasma basal levels of ET-1 were observed between the two groups. However, women suffering from Raynaud's phenomenon responded with a slight but significant elevation in plasma levels of ET-1 after whole-body cooling, whereas the healthy control subjects did not. The results from the present study confirm previous observations that endothelial dysfunction may be of aetiological importance in PRP.
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- author
- Leppert, J ; Ringqvist, Å LU ; Karlberg, B E and Ringqvist, I
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Blood Pressure/physiology, Cold Temperature/adverse effects, Endothelin-1/blood, Female, Heart Rate/physiology, Humans, Middle Aged, Raynaud Disease/blood, Smoking/physiopathology
- in
- Clinical Physiology and Functional Imaging
- volume
- 18
- issue
- 5
- pages
- 5 - 420
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:9784937
- scopus:0031659348
- ISSN
- 0144-5979
- DOI
- 10.1046/j.1365-2281.1998.00105.x
- language
- English
- LU publication?
- no
- id
- d10443fa-50cd-4da8-b5b2-ab0b600772bb
- date added to LUP
- 2022-05-09 14:40:48
- date last changed
- 2024-03-06 06:58:49
@article{d10443fa-50cd-4da8-b5b2-ab0b600772bb,
abstract = {{<p>To understand better the role of endothelin-1 (ET-1) in the pathogenesis of primary Raynaud's phenomenon (PRP), we investigated the basal ET-1 plasma levels and changes after whole-body cooling in healthy women and those with PRP. The study was performed as an open parallel-group comparison during the month of February. The Raynaud group included 21 female patients (mean age 45.3 years, range 21-57 years) who had had disabling Raynaud's phenomenon for a mean period of 17 years (range 2-26 years). The control group consisted of 25 healthy women (mean age 43.6 years, range 27-56 years). Plasma levels of ET-1 were measured on two separate occasions: once after 30 min of rest at room temperature and after 40 min of whole-body cooling. There were no significant differences in baseline plasma ET-1 levels between the two groups of women. The plasma ET-1 levels increased significantly in the PRP group after cold exposure (mean difference 0.11 pmol l-1, 95% CI 0.005-0.214, P = 0.012). In contrast, the levels of plasma ET-1 in the control group did not change significantly after cold provocation. In conclusion, no differences in plasma basal levels of ET-1 were observed between the two groups. However, women suffering from Raynaud's phenomenon responded with a slight but significant elevation in plasma levels of ET-1 after whole-body cooling, whereas the healthy control subjects did not. The results from the present study confirm previous observations that endothelial dysfunction may be of aetiological importance in PRP.</p>}},
author = {{Leppert, J and Ringqvist, Å and Karlberg, B E and Ringqvist, I}},
issn = {{0144-5979}},
keywords = {{Adult; Blood Pressure/physiology; Cold Temperature/adverse effects; Endothelin-1/blood; Female; Heart Rate/physiology; Humans; Middle Aged; Raynaud Disease/blood; Smoking/physiopathology}},
language = {{eng}},
number = {{5}},
pages = {{5--420}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Clinical Physiology and Functional Imaging}},
title = {{Whole-body cooling increases plasma endothelin-1 levels in women with primary Raynaud's phenomenon}},
url = {{http://dx.doi.org/10.1046/j.1365-2281.1998.00105.x}},
doi = {{10.1046/j.1365-2281.1998.00105.x}},
volume = {{18}},
year = {{1998}},
}