Excess mortality in incident cases of diabetes mellitus aged 15 to 34 years at diagnosis: a population-based study (DISS) in Sweden
(2006) In Diabetologia 49(4). p.653-659- Abstract
- Aims/hypothesis: The objective of the study was to analyse the mortality, survival and cause of death patterns in incident cases of diabetes in the 15-34-year age group that were reported to the nationwide prospective Diabetes Incidence Study in Sweden (DISS). Methods: During the study period 1983-1999, 6,771 incident cases were reported. Identification of deaths was made by linking the records to the nationwide Cause of Death Register. Results: With an average follow-up of 8.5 years, resulting in 59,231 person-years, 159 deaths were identified. Diabetes was reported as the underlying cause of death in 51 patients (32%), and as a contributing cause of death in another 42 patients (26%). The standardised mortality ratio (SMR) was... (More)
- Aims/hypothesis: The objective of the study was to analyse the mortality, survival and cause of death patterns in incident cases of diabetes in the 15-34-year age group that were reported to the nationwide prospective Diabetes Incidence Study in Sweden (DISS). Methods: During the study period 1983-1999, 6,771 incident cases were reported. Identification of deaths was made by linking the records to the nationwide Cause of Death Register. Results: With an average follow-up of 8.5 years, resulting in 59,231 person-years, 159 deaths were identified. Diabetes was reported as the underlying cause of death in 51 patients (32%), and as a contributing cause of death in another 42 patients (26%). The standardised mortality ratio (SMR) was significantly elevated (RR=2.4; 95% CI: 2.0-2.8). The SMR was higher for patients classified by the reporting physician as having type 2 diabetes at diagnosis than for those classified as type 1 diabetic (2.9 and 1.8, respectively). Survival analysis showed significant differences in survival curves between males and females (p=0.0003) as well as between cases with different types of diabetes (p=0.005). This pattern was also reflected in the Cox regression model showing significantly increased hazard for males vs females (p=0.0002), and for type 2 vs type 1 (p=0.015) when controlling for age. Conclusions/interpretation: This study shows a two-fold excess mortality in patients with type 1 diabetes and a three-fold excess mortality in patients with type 2 diabetes. Thus, despite advances in treatment, diabetes still carries an increased mortality in young adults, even in a country with a good economic and educational patient status and easy access to health care. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/693540
- author
- Waernbaum, I ; Blohme, G ; Ostman, J ; Sundkvist, Göran LU ; Eriksson, JW ; Arnqvist, HJ ; Bolinder, J and Nystrom, L
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- type 2 diabetes, type 1 diabetes, mortality, cause of death, cohort
- in
- Diabetologia
- volume
- 49
- issue
- 4
- pages
- 653 - 659
- publisher
- Springer
- external identifiers
-
- wos:000235900100007
- pmid:16447054
- scopus:33644826995
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-005-0135-x
- language
- English
- LU publication?
- yes
- id
- d1a4b564-1b91-4b76-b805-25f111546861 (old id 693540)
- date added to LUP
- 2016-04-01 12:34:38
- date last changed
- 2022-05-19 07:26:38
@article{d1a4b564-1b91-4b76-b805-25f111546861,
abstract = {{Aims/hypothesis: The objective of the study was to analyse the mortality, survival and cause of death patterns in incident cases of diabetes in the 15-34-year age group that were reported to the nationwide prospective Diabetes Incidence Study in Sweden (DISS). Methods: During the study period 1983-1999, 6,771 incident cases were reported. Identification of deaths was made by linking the records to the nationwide Cause of Death Register. Results: With an average follow-up of 8.5 years, resulting in 59,231 person-years, 159 deaths were identified. Diabetes was reported as the underlying cause of death in 51 patients (32%), and as a contributing cause of death in another 42 patients (26%). The standardised mortality ratio (SMR) was significantly elevated (RR=2.4; 95% CI: 2.0-2.8). The SMR was higher for patients classified by the reporting physician as having type 2 diabetes at diagnosis than for those classified as type 1 diabetic (2.9 and 1.8, respectively). Survival analysis showed significant differences in survival curves between males and females (p=0.0003) as well as between cases with different types of diabetes (p=0.005). This pattern was also reflected in the Cox regression model showing significantly increased hazard for males vs females (p=0.0002), and for type 2 vs type 1 (p=0.015) when controlling for age. Conclusions/interpretation: This study shows a two-fold excess mortality in patients with type 1 diabetes and a three-fold excess mortality in patients with type 2 diabetes. Thus, despite advances in treatment, diabetes still carries an increased mortality in young adults, even in a country with a good economic and educational patient status and easy access to health care.}},
author = {{Waernbaum, I and Blohme, G and Ostman, J and Sundkvist, Göran and Eriksson, JW and Arnqvist, HJ and Bolinder, J and Nystrom, L}},
issn = {{1432-0428}},
keywords = {{type 2 diabetes; type 1 diabetes; mortality; cause of death; cohort}},
language = {{eng}},
number = {{4}},
pages = {{653--659}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Excess mortality in incident cases of diabetes mellitus aged 15 to 34 years at diagnosis: a population-based study (DISS) in Sweden}},
url = {{http://dx.doi.org/10.1007/s00125-005-0135-x}},
doi = {{10.1007/s00125-005-0135-x}},
volume = {{49}},
year = {{2006}},
}