Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Accelerating research on biological aging and mental health : Current challenges and future directions

Han, Laura K.M. ; Verhoeven, Josine E. ; Tyrka, Audrey R. ; Penninx, Brenda W.J.H. ; Wolkowitz, Owen M. LU ; Månsson, Kristoffer N.T. ; Lindqvist, Daniel LU ; Boks, Marco P. ; Révész, Dóra and Mellon, Synthia H. , et al. (2019) In Psychoneuroendocrinology 106. p.293-311
Abstract

Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential strategies to accelerate progress in this field. This effort requires the interaction of scientists across disciplines - including biology, psychiatry, psychology, and epidemiology; and across levels of analysis that emphasize different outcome measures - functional capacity, physiological, cellular, and molecular. Dialogues across disciplines... (More)

Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential strategies to accelerate progress in this field. This effort requires the interaction of scientists across disciplines - including biology, psychiatry, psychology, and epidemiology; and across levels of analysis that emphasize different outcome measures - functional capacity, physiological, cellular, and molecular. Dialogues across disciplines and levels of analysis naturally lead to new opportunities for discovery but also to stimulating challenges. Some important challenges consist of 1)establishing the best objective and predictive biological age indicators or combinations of indicators, 2)identifying the basis for inter-individual differences in the rate of biological aging, and 3)examining to what extent interventions can delay, halt or temporarily reverse aging trajectories. Discovering how psychological states influence biological aging, and vice versa, has the potential to create novel and exciting opportunities for healthcare and possibly yield insights into the fundamental mechanisms that drive human aging.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biological age, Brain, DNA methylation, Mitochondria, Psychopathology, Telomere length
in
Psychoneuroendocrinology
volume
106
pages
293 - 311
publisher
Elsevier
external identifiers
  • pmid:31154264
  • scopus:85067209670
ISSN
0306-4530
DOI
10.1016/j.psyneuen.2019.04.004
language
English
LU publication?
yes
id
d1a4fdae-5b88-4daf-8fad-7f6f5b42511a
date added to LUP
2020-11-24 15:56:10
date last changed
2024-05-30 00:07:29
@article{d1a4fdae-5b88-4daf-8fad-7f6f5b42511a,
  abstract     = {{<p>Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential strategies to accelerate progress in this field. This effort requires the interaction of scientists across disciplines - including biology, psychiatry, psychology, and epidemiology; and across levels of analysis that emphasize different outcome measures - functional capacity, physiological, cellular, and molecular. Dialogues across disciplines and levels of analysis naturally lead to new opportunities for discovery but also to stimulating challenges. Some important challenges consist of 1)establishing the best objective and predictive biological age indicators or combinations of indicators, 2)identifying the basis for inter-individual differences in the rate of biological aging, and 3)examining to what extent interventions can delay, halt or temporarily reverse aging trajectories. Discovering how psychological states influence biological aging, and vice versa, has the potential to create novel and exciting opportunities for healthcare and possibly yield insights into the fundamental mechanisms that drive human aging.</p>}},
  author       = {{Han, Laura K.M. and Verhoeven, Josine E. and Tyrka, Audrey R. and Penninx, Brenda W.J.H. and Wolkowitz, Owen M. and Månsson, Kristoffer N.T. and Lindqvist, Daniel and Boks, Marco P. and Révész, Dóra and Mellon, Synthia H. and Picard, Martin}},
  issn         = {{0306-4530}},
  keywords     = {{Biological age; Brain; DNA methylation; Mitochondria; Psychopathology; Telomere length}},
  language     = {{eng}},
  pages        = {{293--311}},
  publisher    = {{Elsevier}},
  series       = {{Psychoneuroendocrinology}},
  title        = {{Accelerating research on biological aging and mental health : Current challenges and future directions}},
  url          = {{http://dx.doi.org/10.1016/j.psyneuen.2019.04.004}},
  doi          = {{10.1016/j.psyneuen.2019.04.004}},
  volume       = {{106}},
  year         = {{2019}},
}