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Dynamic alterations in the central glutamatergic status following food and glucose intake : in vivo multimodal assessments in humans and animal models

Kubota, Manabu ; Kimura, Yasuyuki ; Shimojo, Masafumi ; Takado, Yuhei ; Duarte, Joao M.N. LU orcid ; Takuwa, Hiroyuki ; Seki, Chie ; Shimada, Hitoshi ; Shinotoh, Hitoshi and Takahata, Keisuke , et al. (2021) In Journal of Cerebral Blood Flow and Metabolism 41(11). p.2928-2943
Abstract

Fluctuations of neuronal activities in the brain may underlie relatively slow components of neurofunctional alterations, which can be modulated by food intake and related systemic metabolic statuses. Glutamatergic neurotransmission plays a major role in the regulation of excitatory tones in the central nervous system, although just how dietary elements contribute to the tuning of this system remains elusive. Here, we provide the first demonstration by bimodal positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) that metabotropic glutamate receptor subtype 5 (mGluR5) ligand binding and glutamate levels in human brains are dynamically altered in a manner dependent on food intake and consequent changes in plasma... (More)

Fluctuations of neuronal activities in the brain may underlie relatively slow components of neurofunctional alterations, which can be modulated by food intake and related systemic metabolic statuses. Glutamatergic neurotransmission plays a major role in the regulation of excitatory tones in the central nervous system, although just how dietary elements contribute to the tuning of this system remains elusive. Here, we provide the first demonstration by bimodal positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) that metabotropic glutamate receptor subtype 5 (mGluR5) ligand binding and glutamate levels in human brains are dynamically altered in a manner dependent on food intake and consequent changes in plasma glucose levels. The brain-wide modulations of central mGluR5 ligand binding and glutamate levels and profound neuronal activations following systemic glucose administration were further proven by PET, MRS, and intravital two-photon microscopy, respectively, in living rodents. The present findings consistently support the notion that food-associated glucose intake is mechanistically linked to glutamatergic tones in the brain, which are translationally accessible in vivo by bimodal PET and MRS measurements in both clinical and non-clinical settings.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glucose, glutamate, magnetic resonance spectroscopy, metabotropic glutamate receptor subtype 5, positron emission tomography
in
Journal of Cerebral Blood Flow and Metabolism
volume
41
issue
11
pages
2928 - 2943
publisher
Nature Publishing Group
external identifiers
  • scopus:85106719601
  • pmid:34039039
ISSN
0271-678X
DOI
10.1177/0271678X211004150
language
English
LU publication?
yes
id
d1adaa9f-6670-4417-a860-f4cbe799428a
date added to LUP
2021-06-14 10:33:54
date last changed
2024-06-15 12:33:37
@article{d1adaa9f-6670-4417-a860-f4cbe799428a,
  abstract     = {{<p>Fluctuations of neuronal activities in the brain may underlie relatively slow components of neurofunctional alterations, which can be modulated by food intake and related systemic metabolic statuses. Glutamatergic neurotransmission plays a major role in the regulation of excitatory tones in the central nervous system, although just how dietary elements contribute to the tuning of this system remains elusive. Here, we provide the first demonstration by bimodal positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) that metabotropic glutamate receptor subtype 5 (mGluR5) ligand binding and glutamate levels in human brains are dynamically altered in a manner dependent on food intake and consequent changes in plasma glucose levels. The brain-wide modulations of central mGluR5 ligand binding and glutamate levels and profound neuronal activations following systemic glucose administration were further proven by PET, MRS, and intravital two-photon microscopy, respectively, in living rodents. The present findings consistently support the notion that food-associated glucose intake is mechanistically linked to glutamatergic tones in the brain, which are translationally accessible in vivo by bimodal PET and MRS measurements in both clinical and non-clinical settings.</p>}},
  author       = {{Kubota, Manabu and Kimura, Yasuyuki and Shimojo, Masafumi and Takado, Yuhei and Duarte, Joao M.N. and Takuwa, Hiroyuki and Seki, Chie and Shimada, Hitoshi and Shinotoh, Hitoshi and Takahata, Keisuke and Kitamura, Soichiro and Moriguchi, Sho and Tagai, Kenji and Obata, Takayuki and Nakahara, Jin and Tomita, Yutaka and Tokunaga, Masaki and Maeda, Jun and Kawamura, Kazunori and Zhang, Ming Rong and Ichise, Masanori and Suhara, Tetsuya and Higuchi, Makoto}},
  issn         = {{0271-678X}},
  keywords     = {{glucose; glutamate; magnetic resonance spectroscopy; metabotropic glutamate receptor subtype 5; positron emission tomography}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2928--2943}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Journal of Cerebral Blood Flow and Metabolism}},
  title        = {{Dynamic alterations in the central glutamatergic status following food and glucose intake : in vivo multimodal assessments in humans and animal models}},
  url          = {{http://dx.doi.org/10.1177/0271678X211004150}},
  doi          = {{10.1177/0271678X211004150}},
  volume       = {{41}},
  year         = {{2021}},
}