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Trends in the design and use of elastin-like recombinamers as biomaterials

Ibáñez-Fonseca, Arturo LU orcid ; Flora, Tatjana ; Acosta, Sergio and Rodríguez-Cabello, José Carlos (2019) In Matrix Biology 84. p.111-126
Abstract

Elastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs) and its relevance for some biomedical applications. Furthermore, we summarize the current knowledge on the development of drug, vaccine and gene delivery systems based on ELRs, while also emphasizing the use of ELR-based hydrogels in tissue engineering and regenerative medicine (TERM). Finally, we show different studies that explore... (More)

Elastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs) and its relevance for some biomedical applications. Furthermore, we summarize the current knowledge on the development of drug, vaccine and gene delivery systems based on ELRs, while also emphasizing the use of ELR-based hydrogels in tissue engineering and regenerative medicine (TERM). Finally, we show different studies that explore applications in other fields, and several examples that describe biomaterial blends in which ELRs have a key role. This review aims to give an overview of the recent advances regarding ELRs and to encourage further investigation of their properties and applications.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Biocompatible Materials/chemical synthesis, Elastin/chemistry, Gene Transfer Techniques, Humans, Hydrogels/chemistry, Intrinsically Disordered Proteins/chemistry, Peptides/chemical synthesis, Protein Domains, Regenerative Medicine, Tissue Engineering
in
Matrix Biology
volume
84
pages
111 - 126
publisher
Elsevier
external identifiers
  • pmid:31288085
  • scopus:85069474665
ISSN
1569-1802
DOI
10.1016/j.matbio.2019.07.003
language
English
LU publication?
no
additional info
Copyright © 2019 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.
id
d20fdc16-d6d7-4e73-b5a9-2d7995afeb70
date added to LUP
2025-09-14 19:44:45
date last changed
2025-10-14 08:55:17
@article{d20fdc16-d6d7-4e73-b5a9-2d7995afeb70,
  abstract     = {{<p>Elastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs) and its relevance for some biomedical applications. Furthermore, we summarize the current knowledge on the development of drug, vaccine and gene delivery systems based on ELRs, while also emphasizing the use of ELR-based hydrogels in tissue engineering and regenerative medicine (TERM). Finally, we show different studies that explore applications in other fields, and several examples that describe biomaterial blends in which ELRs have a key role. This review aims to give an overview of the recent advances regarding ELRs and to encourage further investigation of their properties and applications.</p>}},
  author       = {{Ibáñez-Fonseca, Arturo and Flora, Tatjana and Acosta, Sergio and Rodríguez-Cabello, José Carlos}},
  issn         = {{1569-1802}},
  keywords     = {{Biocompatible Materials/chemical synthesis; Elastin/chemistry; Gene Transfer Techniques; Humans; Hydrogels/chemistry; Intrinsically Disordered Proteins/chemistry; Peptides/chemical synthesis; Protein Domains; Regenerative Medicine; Tissue Engineering}},
  language     = {{eng}},
  pages        = {{111--126}},
  publisher    = {{Elsevier}},
  series       = {{Matrix Biology}},
  title        = {{Trends in the design and use of elastin-like recombinamers as biomaterials}},
  url          = {{http://dx.doi.org/10.1016/j.matbio.2019.07.003}},
  doi          = {{10.1016/j.matbio.2019.07.003}},
  volume       = {{84}},
  year         = {{2019}},
}