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Male factor infertility and risk of multiple sclerosis : A register-based cohort study

Glazer, Clara Helene; Tøttenborg, Sandra Søgaard; Giwercman, Aleksander LU ; Bräuner, Elvira Vaclavik; Eisenberg, Michael L.; Vassard, Ditte; Magyari, Melinda; Pinborg, Anja; Schmidt, Lone and Bonde, Jens Peter (2017) In Multiple Sclerosis Journal
Abstract

Background: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. Objective: To study the association between male factor infertility and prevalent as well as incident MS. Method: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015. Results: With a median age of 34 years at baseline, 24,011 men were diagnosed with male factor infertility and... (More)

Background: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. Objective: To study the association between male factor infertility and prevalent as well as incident MS. Method: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015. Results: With a median age of 34 years at baseline, 24,011 men were diagnosed with male factor infertility and 27,052 did not have male factor infertility and made up the reference group. Men diagnosed with male factor infertility had a higher risk of prevalent (odds ratio (OR) = 1.61, 95% confidence interval (95% CI) 1.04–2.51) and incident MS (hazard ratio (HR) = 1.28, 95% CI 0.76–2.17) when compared to the reference group. Conclusion: This nationwide cohort study has shown, for the first time, an association between male infertility and MS which may be due to underlying common etiologies such as hypogonadism, shared genetics, or a joint autoimmune component.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
epidemiology, fertility, gender, Male infertility, multiple sclerosis, semen quality
in
Multiple Sclerosis Journal
publisher
Arnold, Hodder Headline PLC
external identifiers
  • scopus:85043306664
ISSN
1352-4585
DOI
10.1177/1352458517734069
language
English
LU publication?
yes
id
d25d8781-2839-42d3-9b91-b9684c9e5082
date added to LUP
2018-03-26 13:06:47
date last changed
2018-09-16 04:54:14
@article{d25d8781-2839-42d3-9b91-b9684c9e5082,
  abstract     = {<p>Background: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. Objective: To study the association between male factor infertility and prevalent as well as incident MS. Method: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015. Results: With a median age of 34 years at baseline, 24,011 men were diagnosed with male factor infertility and 27,052 did not have male factor infertility and made up the reference group. Men diagnosed with male factor infertility had a higher risk of prevalent (odds ratio (OR) = 1.61, 95% confidence interval (95% CI) 1.04–2.51) and incident MS (hazard ratio (HR) = 1.28, 95% CI 0.76–2.17) when compared to the reference group. Conclusion: This nationwide cohort study has shown, for the first time, an association between male infertility and MS which may be due to underlying common etiologies such as hypogonadism, shared genetics, or a joint autoimmune component.</p>},
  author       = {Glazer, Clara Helene and Tøttenborg, Sandra Søgaard and Giwercman, Aleksander and Bräuner, Elvira Vaclavik and Eisenberg, Michael L. and Vassard, Ditte and Magyari, Melinda and Pinborg, Anja and Schmidt, Lone and Bonde, Jens Peter},
  issn         = {1352-4585},
  keyword      = {epidemiology,fertility,gender,Male infertility,multiple sclerosis,semen quality},
  language     = {eng},
  month        = {10},
  publisher    = {Arnold, Hodder Headline PLC},
  series       = {Multiple Sclerosis Journal},
  title        = {Male factor infertility and risk of multiple sclerosis : A register-based cohort study},
  url          = {http://dx.doi.org/10.1177/1352458517734069},
  year         = {2017},
}