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Considerations for the design, analysis and presentation of in vivo studies

Ranstam, J LU and Cook, J A (2017) In Osteoarthritis and Cartilage 25(3). p.364-368
Abstract

OBJECTIVE: To describe, explain and give practical suggestions regarding important principles and key methodological challenges in the study design, statistical analysis, and reporting of results from in vivo studies.

CONCLUSIONS: Pre-specifying endpoints and analysis, recognizing the common underlying assumption of statistically independent observations, performing sample size calculations, and addressing multiplicity issues are important parts of an in vivo study. A clear reporting of results and informative graphical presentations of data are other important parts.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Biomedical Research/methods, Clinical Protocols/standards, Data Interpretation, Statistical, Humans, Osteoarthritis/therapy, Publications/standards, Randomized Controlled Trials as Topic/methods, Research Design, Sample Size
in
Osteoarthritis and Cartilage
volume
25
issue
3
pages
364 - 368
publisher
Elsevier
external identifiers
  • scopus:84981703895
  • pmid:27480934
ISSN
1063-4584
DOI
10.1016/j.joca.2016.06.023
language
English
LU publication?
no
additional info
Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
id
d281919b-bdec-4d9a-9cad-b4bb57243d4b
date added to LUP
2019-06-24 15:49:24
date last changed
2020-04-02 02:35:34
@article{d281919b-bdec-4d9a-9cad-b4bb57243d4b,
  abstract     = {<p>OBJECTIVE: To describe, explain and give practical suggestions regarding important principles and key methodological challenges in the study design, statistical analysis, and reporting of results from in vivo studies.</p><p>CONCLUSIONS: Pre-specifying endpoints and analysis, recognizing the common underlying assumption of statistically independent observations, performing sample size calculations, and addressing multiplicity issues are important parts of an in vivo study. A clear reporting of results and informative graphical presentations of data are other important parts.</p>},
  author       = {Ranstam, J and Cook, J A},
  issn         = {1063-4584},
  language     = {eng},
  number       = {3},
  pages        = {364--368},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Considerations for the design, analysis and presentation of in vivo studies},
  url          = {http://dx.doi.org/10.1016/j.joca.2016.06.023},
  doi          = {10.1016/j.joca.2016.06.023},
  volume       = {25},
  year         = {2017},
}