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Reduced venous compliance in lower limbs of aging humans and its importance for capacitance function

Olsen, H LU and Länne, T (1998) In American Journal of Physiology 275(3). p.878-886
Abstract

Venous compliance in the calf of humans and its importance for capacitance function in relation to age were studied with the aid of 22, 44, and 59 mmHg lower body negative pressure (LBNP). Negative pressure transmission to the calf as well as changes in calf volume were studied, and venous compliance was calculated [change in volume with pressure change (dV/dP)]. The change in capacitance response of the calf with age (20-70 yr) was evaluated during LBNP 44 mmHg. Transmission of negative pressure to the subcutaneous tissue was almost full without any changes with age (92%). However, it was reduced to 80% in the underlying muscle tissue, irrespective of depth. Venous compliance in the young was 0.051 ml . 100 ml-1 . mmHg-1 and was... (More)

Venous compliance in the calf of humans and its importance for capacitance function in relation to age were studied with the aid of 22, 44, and 59 mmHg lower body negative pressure (LBNP). Negative pressure transmission to the calf as well as changes in calf volume were studied, and venous compliance was calculated [change in volume with pressure change (dV/dP)]. The change in capacitance response of the calf with age (20-70 yr) was evaluated during LBNP 44 mmHg. Transmission of negative pressure to the subcutaneous tissue was almost full without any changes with age (92%). However, it was reduced to 80% in the underlying muscle tissue, irrespective of depth. Venous compliance in the young was 0.051 ml . 100 ml-1 . mmHg-1 and was reduced by 45% to 0.029 ml . 100 ml-1 . mmHg-1 in the old (P < 0.05). Accordingly, the capacitance response was reduced by 0.015 ml . 100 ml-1 . yr-1 (P < 0.005). Furthermore, the hemodynamic response to hypovolemic circulatory stress was attenuated with age. The reduced pressure transmission in muscle tissue is probably due to restriction of the muscle fascia envelope. The reduced venous compliance with age and the concomitant reduction in capacitance response during LBNP have implications for both the sympathetic reflex responses as well as the capacitance response during acute hypovolemic circulatory stress, which might be defected in aging humans.

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Contribution to journal
publication status
published
subject
keywords
Adult, Aged, Aging/physiology, Biomechanical Phenomena, Blood Pressure, Compliance, Elasticity, Hemodynamics, Humans, Leg/blood supply, Lower Body Negative Pressure, Male, Middle Aged, Muscle, Skeletal/blood supply, Vascular Capacitance/physiology, Veins/physiology, Viscosity
in
American Journal of Physiology
volume
275
issue
3
pages
878 - 886
publisher
American Physiological Society
external identifiers
  • pmid:9724292
ISSN
0002-9513
DOI
10.1152/ajpheart.1998.275.3.H878
language
English
LU publication?
yes
id
d283c9ba-b1de-456a-a4dd-8ec3e2d617c3
date added to LUP
2019-05-29 09:12:31
date last changed
2019-11-28 04:02:48
@article{d283c9ba-b1de-456a-a4dd-8ec3e2d617c3,
  abstract     = {<p>Venous compliance in the calf of humans and its importance for capacitance function in relation to age were studied with the aid of 22, 44, and 59 mmHg lower body negative pressure (LBNP). Negative pressure transmission to the calf as well as changes in calf volume were studied, and venous compliance was calculated [change in volume with pressure change (dV/dP)]. The change in capacitance response of the calf with age (20-70 yr) was evaluated during LBNP 44 mmHg. Transmission of negative pressure to the subcutaneous tissue was almost full without any changes with age (92%). However, it was reduced to 80% in the underlying muscle tissue, irrespective of depth. Venous compliance in the young was 0.051 ml . 100 ml-1 . mmHg-1 and was reduced by 45% to 0.029 ml . 100 ml-1 . mmHg-1 in the old (P &lt; 0.05). Accordingly, the capacitance response was reduced by 0.015 ml . 100 ml-1 . yr-1 (P &lt; 0.005). Furthermore, the hemodynamic response to hypovolemic circulatory stress was attenuated with age. The reduced pressure transmission in muscle tissue is probably due to restriction of the muscle fascia envelope. The reduced venous compliance with age and the concomitant reduction in capacitance response during LBNP have implications for both the sympathetic reflex responses as well as the capacitance response during acute hypovolemic circulatory stress, which might be defected in aging humans.</p>},
  author       = {Olsen, H and Länne, T},
  issn         = {0002-9513},
  language     = {eng},
  number       = {3},
  pages        = {878--886},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology},
  title        = {Reduced venous compliance in lower limbs of aging humans and its importance for capacitance function},
  url          = {http://dx.doi.org/10.1152/ajpheart.1998.275.3.H878},
  doi          = {10.1152/ajpheart.1998.275.3.H878},
  volume       = {275},
  year         = {1998},
}