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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

, ; Giri, Ayush; Almgren, Peter LU ; Melander, Olle LU ; Hung, Adriana M. and Edwards, Todd L (2019) In Nature Genetics 51(1). p.51-62
Abstract
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney... (More)
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
51
issue
1
pages
12 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85058906993
ISSN
1546-1718
DOI
10.1038/s41588-018-0303-9
language
English
LU publication?
yes
id
d28b8d79-9174-4253-ae9e-845b2add5318
date added to LUP
2019-01-03 09:01:53
date last changed
2019-07-16 04:02:39
@article{d28b8d79-9174-4253-ae9e-845b2add5318,
  abstract     = {In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.},
  author       = {,  and Giri, Ayush and Almgren, Peter and Melander, Olle and Hung, Adriana M.  and Edwards, Todd L},
  issn         = {1546-1718},
  language     = {eng},
  number       = {1},
  pages        = {51--62},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Trans-ethnic association study of blood pressure determinants in over 750,000 individuals},
  url          = {http://dx.doi.org/10.1038/s41588-018-0303-9},
  volume       = {51},
  year         = {2019},
}