Age-related reference limits for urine levels of albumin, orosomucoid, immunoglobulin G and protein HC in children
Hjorth, L LU ; Helin, I and Grubb, A LU
(2000)
In Scandinavian Journal of Clinical and Laboratory Investigation
60.
p.65-73
- Abstract
Urine levels of albumin, orosomucoid (alias alpha1-acid glycoprotein), immunoglobulin G (IgG) and protein HC (alias alpha1-microglobulin) were determined in 247 healthy Swedish infants and children aged 1 day to 15 years. Urine samples were collected and stored in conditions known to guarantee stable protein levels. The protein levels were measured both as mass concentrations (mg l(-1)) and as protein-creatinine ratios (mg mmol(-1)). In an effort to arrive at practically useful upper reference limits, the variability with age for both units was analysed. The variability with age for the levels of three of the four proteins was considerably lower when the levels were expressed as creatinine ratios rather than as mass concentrations. The... (More)
Urine levels of albumin, orosomucoid (alias alpha1-acid glycoprotein), immunoglobulin G (IgG) and protein HC (alias alpha1-microglobulin) were determined in 247 healthy Swedish infants and children aged 1 day to 15 years. Urine samples were collected and stored in conditions known to guarantee stable protein levels. The protein levels were measured both as mass concentrations (mg l(-1)) and as protein-creatinine ratios (mg mmol(-1)). In an effort to arrive at practically useful upper reference limits, the variability with age for both units was analysed. The variability with age for the levels of three of the four proteins was considerably lower when the levels were expressed as creatinine ratios rather than as mass concentrations. The results allowed suggestion of the following upper reference limits, expressed as mg mmol(-1) creatinine, for use in clinical practise: IgG, 1 month to 15 years: 1.0; protein HC, 1 month to 15 years: 0.8; orosomucoid, 1 month to 15 years: 0.5; albumin, 1 month to 1 year: 3.8; 1-5 years: 3.3; 6-10 years: 2.7; 11-15 years: 2.1. In the immediate neonatal period the urine levels of all proteins were high and very variable.
(Less)
- author
- Hjorth, L
LU
; Helin, I
and Grubb, A
LU
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- keywords
- Adolescent, Age Factors, Albuminuria/diagnosis, Alpha-Globulins/urine, Chemistry, Clinical/standards, Child, Child, Preschool, Confidence Intervals, Creatinine/urine, Female, Humans, Immunoglobulin G/urine, Infant, Infant, Newborn, Male, Orosomucoid/urine, Proportional Hazards Models, Reference Values, Regression Analysis
- in
- Scandinavian Journal of Clinical and Laboratory Investigation
- volume
- 60
- pages
- 65 - 73
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:10757455
- scopus:0034102738
- ISSN
- 0036-5513
- DOI
- 10.1080/00365510050185056
- language
- English
- LU publication?
- no
- id
- d2aebd80-2596-4a11-8f5a-34652f752f24
- date added to LUP
- 2021-11-02 14:01:50
- date last changed
- 2024-04-20 15:49:03
@article{d2aebd80-2596-4a11-8f5a-34652f752f24,
abstract = {{<p>Urine levels of albumin, orosomucoid (alias alpha1-acid glycoprotein), immunoglobulin G (IgG) and protein HC (alias alpha1-microglobulin) were determined in 247 healthy Swedish infants and children aged 1 day to 15 years. Urine samples were collected and stored in conditions known to guarantee stable protein levels. The protein levels were measured both as mass concentrations (mg l(-1)) and as protein-creatinine ratios (mg mmol(-1)). In an effort to arrive at practically useful upper reference limits, the variability with age for both units was analysed. The variability with age for the levels of three of the four proteins was considerably lower when the levels were expressed as creatinine ratios rather than as mass concentrations. The results allowed suggestion of the following upper reference limits, expressed as mg mmol(-1) creatinine, for use in clinical practise: IgG, 1 month to 15 years: 1.0; protein HC, 1 month to 15 years: 0.8; orosomucoid, 1 month to 15 years: 0.5; albumin, 1 month to 1 year: 3.8; 1-5 years: 3.3; 6-10 years: 2.7; 11-15 years: 2.1. In the immediate neonatal period the urine levels of all proteins were high and very variable.</p>}},
author = {{Hjorth, L and Helin, I and Grubb, A}},
issn = {{0036-5513}},
keywords = {{Adolescent; Age Factors; Albuminuria/diagnosis; Alpha-Globulins/urine; Chemistry, Clinical/standards; Child; Child, Preschool; Confidence Intervals; Creatinine/urine; Female; Humans; Immunoglobulin G/urine; Infant; Infant, Newborn; Male; Orosomucoid/urine; Proportional Hazards Models; Reference Values; Regression Analysis}},
language = {{eng}},
pages = {{65--73}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical and Laboratory Investigation}},
title = {{Age-related reference limits for urine levels of albumin, orosomucoid, immunoglobulin G and protein HC in children}},
url = {{http://dx.doi.org/10.1080/00365510050185056}},
doi = {{10.1080/00365510050185056}},
volume = {{60}},
year = {{2000}},
}