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Customisable 3D printed microfluidics for integrated analysis and optimisation

Monaghan, T.; Harding, M. J.; Harris, R. A.; Friel, R. J. LU and Christie, S. D R (2016) In Lab on a Chip - Miniaturisation for Chemistry and Biology 16(17). p.3362-3373
Abstract

The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100-500 μm) means that these devices were capable of handling a wide range of concentrations (9... (More)

The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100-500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM-38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.

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author
publishing date
type
Contribution to journal
publication status
published
in
Lab on a Chip - Miniaturisation for Chemistry and Biology
volume
16
issue
17
pages
12 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:84983301283
ISSN
1473-0197
DOI
10.1039/c6lc00562d
language
English
LU publication?
no
id
d2b4ec31-78be-4bb5-8df3-dafe60b52c4a
date added to LUP
2017-01-23 09:47:47
date last changed
2017-10-22 05:25:18
@article{d2b4ec31-78be-4bb5-8df3-dafe60b52c4a,
  abstract     = {<p>The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100-500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM-38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.</p>},
  author       = {Monaghan, T. and Harding, M. J. and Harris, R. A. and Friel, R. J. and Christie, S. D R},
  issn         = {1473-0197},
  language     = {eng},
  number       = {17},
  pages        = {3362--3373},
  publisher    = {Royal Society of Chemistry},
  series       = {Lab on a Chip - Miniaturisation for Chemistry and Biology},
  title        = {Customisable 3D printed microfluidics for integrated analysis and optimisation},
  url          = {http://dx.doi.org/10.1039/c6lc00562d},
  volume       = {16},
  year         = {2016},
}