Customisable 3D printed microfluidics for integrated analysis and optimisation
(2016) In Lab on a Chip - Miniaturisation for Chemistry and Biology 16(17). p.3362-3373- Abstract
The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100-500 μm) means that these devices were capable of handling a wide range of concentrations (9... (More)
The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100-500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM-38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.
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- author
- Monaghan, T. ; Harding, M. J. ; Harris, R. A. ; Friel, R. J. LU and Christie, S. D R
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- in
- Lab on a Chip - Miniaturisation for Chemistry and Biology
- volume
- 16
- issue
- 17
- pages
- 12 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- pmid:27452498
- scopus:84983301283
- ISSN
- 1473-0197
- DOI
- 10.1039/c6lc00562d
- language
- English
- LU publication?
- no
- id
- d2b4ec31-78be-4bb5-8df3-dafe60b52c4a
- date added to LUP
- 2017-01-23 09:47:47
- date last changed
- 2024-02-03 09:02:01
@article{d2b4ec31-78be-4bb5-8df3-dafe60b52c4a,
abstract = {{<p>The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100-500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM-38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.</p>}},
author = {{Monaghan, T. and Harding, M. J. and Harris, R. A. and Friel, R. J. and Christie, S. D R}},
issn = {{1473-0197}},
language = {{eng}},
number = {{17}},
pages = {{3362--3373}},
publisher = {{Royal Society of Chemistry}},
series = {{Lab on a Chip - Miniaturisation for Chemistry and Biology}},
title = {{Customisable 3D printed microfluidics for integrated analysis and optimisation}},
url = {{http://dx.doi.org/10.1039/c6lc00562d}},
doi = {{10.1039/c6lc00562d}},
volume = {{16}},
year = {{2016}},
}