Morphological detection of neurogenic muscle disorders: how can statistical methods aid diagnosis?
(1987) In Acta Neuropathologica 75(2). p.109-115- Abstract
- The light microscopical observation of groups of histochemically similar muscle fibres, referred to as fibre-type grouping, is commonly considered to be evidence of a denervation and reinnervation process affecting the spinal motor neurons or the peripheral nerves. It can be difficult to assess whether such groups have occurred by chance or are due to a slowly progressive pathological process in an early stage of development. Consequently, there is a need for one or more objective methods for assessing the fibre-type arrangement in healthy and diseased human muscles. The purposes here are to review the methods for the detection of fibre-type grouping that have been published in the last two decades, to describe some unsolved problems, and... (More)
- The light microscopical observation of groups of histochemically similar muscle fibres, referred to as fibre-type grouping, is commonly considered to be evidence of a denervation and reinnervation process affecting the spinal motor neurons or the peripheral nerves. It can be difficult to assess whether such groups have occurred by chance or are due to a slowly progressive pathological process in an early stage of development. Consequently, there is a need for one or more objective methods for assessing the fibre-type arrangement in healthy and diseased human muscles. The purposes here are to review the methods for the detection of fibre-type grouping that have been published in the last two decades, to describe some unsolved problems, and to indicate some likely lines of development. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103950
- author
- Lexell, Jan LU ; Downham, David and Sjöstrom, Michael
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Nerve degeneration, Muscular atrophy, Muscle denervation, Histocytochemistry, Aging
- in
- Acta Neuropathologica
- volume
- 75
- issue
- 2
- pages
- 109 - 115
- publisher
- Springer
- external identifiers
-
- pmid:3324621
- scopus:0023502323
- ISSN
- 1432-0533
- DOI
- 10.1007/BF00687070
- language
- English
- LU publication?
- no
- id
- d2d018fe-2253-438d-b62e-8d337761d220 (old id 1103950)
- date added to LUP
- 2016-04-01 17:10:02
- date last changed
- 2021-06-06 04:50:13
@article{d2d018fe-2253-438d-b62e-8d337761d220,
abstract = {{The light microscopical observation of groups of histochemically similar muscle fibres, referred to as fibre-type grouping, is commonly considered to be evidence of a denervation and reinnervation process affecting the spinal motor neurons or the peripheral nerves. It can be difficult to assess whether such groups have occurred by chance or are due to a slowly progressive pathological process in an early stage of development. Consequently, there is a need for one or more objective methods for assessing the fibre-type arrangement in healthy and diseased human muscles. The purposes here are to review the methods for the detection of fibre-type grouping that have been published in the last two decades, to describe some unsolved problems, and to indicate some likely lines of development.}},
author = {{Lexell, Jan and Downham, David and Sjöstrom, Michael}},
issn = {{1432-0533}},
keywords = {{Nerve degeneration; Muscular atrophy; Muscle denervation; Histocytochemistry; Aging}},
language = {{eng}},
number = {{2}},
pages = {{109--115}},
publisher = {{Springer}},
series = {{Acta Neuropathologica}},
title = {{Morphological detection of neurogenic muscle disorders: how can statistical methods aid diagnosis?}},
url = {{http://dx.doi.org/10.1007/BF00687070}},
doi = {{10.1007/BF00687070}},
volume = {{75}},
year = {{1987}},
}