Trachelectomy and Cerclage Placement as Fertility-Sparing Surgery for Cervical Cancer—An Expert Survey
(2025) In Journal of Personalized Medicine 15(3).- Abstract
Background/Objectives: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. Methods: We conducted a cross-sectional survey from May to July 2023 involving expert centers identified through their scientific contributions and participation in international workgroups and conferences. The survey, comprising 27 questions, evaluated existing practices in FSS. Results: Out of the centers surveyed, 21 (36.2%) gynecologic oncologists responded. For tumors <2 cm,... (More)
Background/Objectives: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. Methods: We conducted a cross-sectional survey from May to July 2023 involving expert centers identified through their scientific contributions and participation in international workgroups and conferences. The survey, comprising 27 questions, evaluated existing practices in FSS. Results: Out of the centers surveyed, 21 (36.2%) gynecologic oncologists responded. For tumors <2 cm, 86% of centers preferred radical trachelectomy, primarily via the vaginal approach, while 13.6% favored a simple trachelectomy. Three experts preferred simple trachelectomy (13.6%). For tumors >2 cm, 47.6% utilized neoadjuvant chemotherapy before trachelectomy. Others did not offer FSS or performed an abdominal radical trachelectomy. Over time, there has been a shift towards less radical surgeries for tumors <2 cm and increased use of neoadjuvant chemotherapy for larger tumors. Some abandoned the minimally invasive surgical approach. Nearly all experts (90.5%) placed a cerclage immediately following trachelectomy. Conclusions: The majority of experts opt for radical trachelectomy in early stage cervical cancer, with immediate cerclage placement being a common practice. However, considerable international variations highlight the urgent need for standardized guidelines and further research to optimize treatment strategies, balancing oncological safety with fertility outcomes.
(Less)
- author
- organization
- publishing date
- 2025-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cerclage, cervical cancer, fertility sparing surgery, minimal invasive surgery, practice variation, trachelectomy
- in
- Journal of Personalized Medicine
- volume
- 15
- issue
- 3
- article number
- 77
- publisher
- MDPI AG
- external identifiers
-
- scopus:105001171796
- pmid:40137393
- ISSN
- 2075-4426
- DOI
- 10.3390/jpm15030077
- language
- English
- LU publication?
- yes
- id
- d2de68ca-4a6b-439d-81c4-ba0ee492cee0
- date added to LUP
- 2025-08-27 12:15:20
- date last changed
- 2025-08-28 04:00:51
@article{d2de68ca-4a6b-439d-81c4-ba0ee492cee0,
abstract = {{<p>Background/Objectives: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. Methods: We conducted a cross-sectional survey from May to July 2023 involving expert centers identified through their scientific contributions and participation in international workgroups and conferences. The survey, comprising 27 questions, evaluated existing practices in FSS. Results: Out of the centers surveyed, 21 (36.2%) gynecologic oncologists responded. For tumors <2 cm, 86% of centers preferred radical trachelectomy, primarily via the vaginal approach, while 13.6% favored a simple trachelectomy. Three experts preferred simple trachelectomy (13.6%). For tumors >2 cm, 47.6% utilized neoadjuvant chemotherapy before trachelectomy. Others did not offer FSS or performed an abdominal radical trachelectomy. Over time, there has been a shift towards less radical surgeries for tumors <2 cm and increased use of neoadjuvant chemotherapy for larger tumors. Some abandoned the minimally invasive surgical approach. Nearly all experts (90.5%) placed a cerclage immediately following trachelectomy. Conclusions: The majority of experts opt for radical trachelectomy in early stage cervical cancer, with immediate cerclage placement being a common practice. However, considerable international variations highlight the urgent need for standardized guidelines and further research to optimize treatment strategies, balancing oncological safety with fertility outcomes.</p>}},
author = {{Smits, Anke and Wolswinkel, Janneke T. and Eikelder, Mieke L.G.ten and Abu-Rustum, Nadeem R. and Baiocchi, Glauco and Beltman, Jogchum J. and Covens, Allan and Cornel, Karlijn M.C. and Falconer, Henrik and Fotopoulou, Christina and Gerestein, Cornelis G. and Gil-Ibanez, Blanca and Hillemanns, Peter and Köhler, Christhardt and Kucukmetin, Ali and van Lonkhuijzen, Luc R.C.W. and Morice, Philippe and Nam, Joo Hyun and Perrotta, Myriam B. and Persson, Jan and Plante, Marie and Querleu, Denis and Ribeiro, Reitan and Ungár, Laszlo and van Ham, Maaike A.P.C. and Zusterzeel, Petra L.M.}},
issn = {{2075-4426}},
keywords = {{cerclage; cervical cancer; fertility sparing surgery; minimal invasive surgery; practice variation; trachelectomy}},
language = {{eng}},
number = {{3}},
publisher = {{MDPI AG}},
series = {{Journal of Personalized Medicine}},
title = {{Trachelectomy and Cerclage Placement as Fertility-Sparing Surgery for Cervical Cancer—An Expert Survey}},
url = {{http://dx.doi.org/10.3390/jpm15030077}},
doi = {{10.3390/jpm15030077}},
volume = {{15}},
year = {{2025}},
}