Radix Polygalae Extract Attenuates PTSD-like Symptoms in a Mouse Model of Single Prolonged Stress and Conditioned Fear Possibly by Reversing BAG1
(2018) In Experimental Neurobiology 27(3). p.200-209- Abstract
Radix Polygalae (RP) has been used to relieve psychological stress in traditional oriental medicine. Recently, cell protective, antiamnestic and antidepressant-like effects were disclosed but the possible application of RP to post-traumatic stress disorder, in which exaggerated fear memory persists, has not yet been explored. For this purpose, the effects of RP on fear behavior was examined in a mouse model of single prolonged stress and conditioned fear (SPS-CF), previously shown to mimic key symptoms of post-traumatic stress disorder. Male mice received daily oral dose of RP extract or vehicle during the SPS-CF procedure. Then fear-related memory (cohort 1, n=25), non-fear-related memory (cohort 2, n=38) and concentration-dependent... (More)
Radix Polygalae (RP) has been used to relieve psychological stress in traditional oriental medicine. Recently, cell protective, antiamnestic and antidepressant-like effects were disclosed but the possible application of RP to post-traumatic stress disorder, in which exaggerated fear memory persists, has not yet been explored. For this purpose, the effects of RP on fear behavior was examined in a mouse model of single prolonged stress and conditioned fear (SPS-CF), previously shown to mimic key symptoms of post-traumatic stress disorder. Male mice received daily oral dose of RP extract or vehicle during the SPS-CF procedure. Then fear-related memory (cohort 1, n=25), non-fear-related memory (cohort 2, n=38) and concentration-dependent effects of RP on fear memory (cohort 3, n=41) were measured in 3 separate cohort of animals. Also working memory and anxiety-like behaviors were measured in cohort 1. RP-treated SPS-CF mice exhibited attenuated contextual but not cued freezing and no impairments in the working memory and spatial reference memory performances relative to vehicle-treated SPS-CF controls. RP-treated SPS-CF and naive mice also demonstrated no difference in anxiety-like behavior levels relative to vehicle-treated SPS-CF and naive controls, respectively. In the hippocampus of SPS-CF mice, expression of BAG1, which regulates the activity of GR, was decreased, whereas RP increased expression of BAG1 in naïve and SPS-CF mice. These results suggest that RP exerts some symptomatic relief in a mouse with exaggerated fear response. RP and its molecular components may thus constitute valuable research targets in the development of novel therapeutics for stress-related psychological disorders.
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- author
- Shin, Ju-Yeon ; Shin, Jung-Won ; Ha, Sang-Kyu ; Kim, Yoorim ; Swanberg, Kelley M LU ; Lee, Suck ; Kim, Tae-Woo and Maeng, Sungho
- publishing date
- 2018-06
- type
- Contribution to journal
- publication status
- published
- in
- Experimental Neurobiology
- volume
- 27
- issue
- 3
- pages
- 200 - 209
- publisher
- Korean Society for Brain and Neural Science
- external identifiers
-
- pmid:30022871
- scopus:85050156743
- ISSN
- 1226-2560
- DOI
- 10.5607/en.2018.27.3.200
- language
- English
- LU publication?
- no
- id
- d2ee9909-5615-4de3-95d1-b626d3f49504
- date added to LUP
- 2023-09-18 15:02:22
- date last changed
- 2024-10-04 18:00:36
@article{d2ee9909-5615-4de3-95d1-b626d3f49504, abstract = {{<p>Radix Polygalae (RP) has been used to relieve psychological stress in traditional oriental medicine. Recently, cell protective, antiamnestic and antidepressant-like effects were disclosed but the possible application of RP to post-traumatic stress disorder, in which exaggerated fear memory persists, has not yet been explored. For this purpose, the effects of RP on fear behavior was examined in a mouse model of single prolonged stress and conditioned fear (SPS-CF), previously shown to mimic key symptoms of post-traumatic stress disorder. Male mice received daily oral dose of RP extract or vehicle during the SPS-CF procedure. Then fear-related memory (cohort 1, n=25), non-fear-related memory (cohort 2, n=38) and concentration-dependent effects of RP on fear memory (cohort 3, n=41) were measured in 3 separate cohort of animals. Also working memory and anxiety-like behaviors were measured in cohort 1. RP-treated SPS-CF mice exhibited attenuated contextual but not cued freezing and no impairments in the working memory and spatial reference memory performances relative to vehicle-treated SPS-CF controls. RP-treated SPS-CF and naive mice also demonstrated no difference in anxiety-like behavior levels relative to vehicle-treated SPS-CF and naive controls, respectively. In the hippocampus of SPS-CF mice, expression of BAG1, which regulates the activity of GR, was decreased, whereas RP increased expression of BAG1 in naïve and SPS-CF mice. These results suggest that RP exerts some symptomatic relief in a mouse with exaggerated fear response. RP and its molecular components may thus constitute valuable research targets in the development of novel therapeutics for stress-related psychological disorders.</p>}}, author = {{Shin, Ju-Yeon and Shin, Jung-Won and Ha, Sang-Kyu and Kim, Yoorim and Swanberg, Kelley M and Lee, Suck and Kim, Tae-Woo and Maeng, Sungho}}, issn = {{1226-2560}}, language = {{eng}}, number = {{3}}, pages = {{200--209}}, publisher = {{Korean Society for Brain and Neural Science}}, series = {{Experimental Neurobiology}}, title = {{Radix Polygalae Extract Attenuates PTSD-like Symptoms in a Mouse Model of Single Prolonged Stress and Conditioned Fear Possibly by Reversing BAG1}}, url = {{http://dx.doi.org/10.5607/en.2018.27.3.200}}, doi = {{10.5607/en.2018.27.3.200}}, volume = {{27}}, year = {{2018}}, }