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Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors

Wassélius, Johan LU ; Larsson, Stig LU ; Sundin, Anders LU and Jacobsson, Hans (2009) In International Journal of Cardiovascular Imaging 25(2). p.40-133
Abstract

PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.

METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.

RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90... (More)

PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.

METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.

RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90 years.

CONCLUSIONS: There is a correlation between the number of cardiovascular risk factors and the number of FDG-accumulating atherosclerotic lesions in this patient material. Statin-treatment was associated with significantly lower numbers of active plaques.

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author
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publication status
published
subject
keywords
Adult, Age Factors, Aged, Aged, 80 and over, Atherosclerosis, Cardiovascular Diseases, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Positron-Emission Tomography, Radiographic Image Interpretation, Computer-Assisted, Radiopharmaceuticals, Risk Factors, Tomography, X-Ray Computed, Journal Article, Research Support, Non-U.S. Gov't
in
International Journal of Cardiovascular Imaging
volume
25
issue
2
pages
8 pages
publisher
Springer
external identifiers
  • scopus:59149090701
ISSN
1875-8312
DOI
10.1007/s10554-008-9366-5
language
English
LU publication?
no
id
d2f8a288-522c-40a9-b59b-77cf23a5906a
date added to LUP
2016-10-14 09:58:21
date last changed
2017-01-01 08:36:45
@article{d2f8a288-522c-40a9-b59b-77cf23a5906a,
  abstract     = {<p>PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.</p><p>METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.</p><p>RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90 years.</p><p>CONCLUSIONS: There is a correlation between the number of cardiovascular risk factors and the number of FDG-accumulating atherosclerotic lesions in this patient material. Statin-treatment was associated with significantly lower numbers of active plaques.</p>},
  author       = {Wassélius, Johan and Larsson, Stig and Sundin, Anders and Jacobsson, Hans},
  issn         = {1875-8312},
  keyword      = {Adult,Age Factors,Aged,Aged, 80 and over,Atherosclerosis,Cardiovascular Diseases,Female,Fluorodeoxyglucose F18,Humans,Male,Middle Aged,Positron-Emission Tomography,Radiographic Image Interpretation, Computer-Assisted,Radiopharmaceuticals,Risk Factors,Tomography, X-Ray Computed,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {2},
  pages        = {40--133},
  publisher    = {Springer},
  series       = {International Journal of Cardiovascular Imaging},
  title        = {Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors},
  url          = {http://dx.doi.org/10.1007/s10554-008-9366-5},
  volume       = {25},
  year         = {2009},
}