Cognitive impairment in preeclampsia complicated by eclampsia and pulmonary edema after delivery
(2021) In Acta Obstetricia et Gynecologica Scandinavica 100(7). p.1280-1287- Abstract
Introduction: We aimed to assess cognitive function in women with preeclampsia stratified by severity, before and after onset of disease. Material and methods: Prospective study performed at a referral hospital in Cape Town, South Africa. Pregnant women between 20 and 42 weeks of gestation with eclampsia, pulmonary edema and preeclampsia without severe features, and a normotensive pregnancy were approached. Women were included at diagnosis of preeclampsia or at admission for delivery (women with normotensive pregnancies). Two cognitive assessments, the Cognitive Failure Questionnaire to assess the cognitive function subjectively before inclusion in the study, and Montreal Cognitive Assessment to assess the current cognitive function... (More)
Introduction: We aimed to assess cognitive function in women with preeclampsia stratified by severity, before and after onset of disease. Material and methods: Prospective study performed at a referral hospital in Cape Town, South Africa. Pregnant women between 20 and 42 weeks of gestation with eclampsia, pulmonary edema and preeclampsia without severe features, and a normotensive pregnancy were approached. Women were included at diagnosis of preeclampsia or at admission for delivery (women with normotensive pregnancies). Two cognitive assessments, the Cognitive Failure Questionnaire to assess the cognitive function subjectively before inclusion in the study, and Montreal Cognitive Assessment to assess the current cognitive function objectively before discharge from the hospital after delivery, were performed. Results: We included 61 women with eclampsia, 28 with preeclampsia complicated by pulmonary edema, 38 with preeclampsia without severe features, and 26 with normotensive pregnancies. There was no difference in cognitive function from early pregnancy between groups. Women with eclampsia and preeclampsia complicated by pulmonary edema scored lower on the Montreal Cognitive Assessment at time of discharge compared with women with normotensive pregnancies. The results were attenuated in pulmonary edema after adjustment for confounders. Conclusions: Women with preeclampsia complicated by pulmonary edema and in particular eclampsia had impaired cognitive function after onset of disease compared with women with normotensive pregnancies. The impairment did not seem to be present before onset of disease. Women with preeclampsia without severe features did not have impaired cognitive function.
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- author
- Bergman, Lina ; Thorgeirsdottir, Lilja ; Elden, Helen ; Hesselman, Susanne ; Schell, Sonja ; Ahlm, Evelina ; Aukes, Annet and Cluver, Catherine
- publishing date
- 2021-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cognitive function, eclampsia, preeclampsia, pulmonary edema
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 100
- issue
- 7
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85100884842
- pmid:33492667
- ISSN
- 0001-6349
- DOI
- 10.1111/aogs.14100
- language
- English
- LU publication?
- no
- additional info
- Funding Information: The study was supported by the Swedish Medical Society, Märta Lundqvist Foundation and Mercy Perinatal. LB is supported by the Swedish Society for Medical Research (SSMF). SH is supported by the Center for Clinical Research Dalarna, Uppsala University (grant CKFUU‐744551). CC receives salary support from the Mercy Perinatal Foundation. Funding Information: The study was supported by the Swedish Medical Society, M?rta Lundqvist Foundation and Mercy Perinatal. LB is supported by the Swedish Society for Medical Research (SSMF). SH is supported by the Center for Clinical Research Dalarna, Uppsala University (grant CKFUU-744551). CC receives salary support from the Mercy Perinatal Foundation. We thank Zukiswa Magogotye for performing cognitive function assessments. Publisher Copyright: © 2021 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).
- id
- d30f27aa-dc6b-4a96-a883-ce787a31a9f7
- date added to LUP
- 2022-03-01 10:13:55
- date last changed
- 2024-06-27 12:34:33
@article{d30f27aa-dc6b-4a96-a883-ce787a31a9f7,
abstract = {{<p>Introduction: We aimed to assess cognitive function in women with preeclampsia stratified by severity, before and after onset of disease. Material and methods: Prospective study performed at a referral hospital in Cape Town, South Africa. Pregnant women between 20 and 42 weeks of gestation with eclampsia, pulmonary edema and preeclampsia without severe features, and a normotensive pregnancy were approached. Women were included at diagnosis of preeclampsia or at admission for delivery (women with normotensive pregnancies). Two cognitive assessments, the Cognitive Failure Questionnaire to assess the cognitive function subjectively before inclusion in the study, and Montreal Cognitive Assessment to assess the current cognitive function objectively before discharge from the hospital after delivery, were performed. Results: We included 61 women with eclampsia, 28 with preeclampsia complicated by pulmonary edema, 38 with preeclampsia without severe features, and 26 with normotensive pregnancies. There was no difference in cognitive function from early pregnancy between groups. Women with eclampsia and preeclampsia complicated by pulmonary edema scored lower on the Montreal Cognitive Assessment at time of discharge compared with women with normotensive pregnancies. The results were attenuated in pulmonary edema after adjustment for confounders. Conclusions: Women with preeclampsia complicated by pulmonary edema and in particular eclampsia had impaired cognitive function after onset of disease compared with women with normotensive pregnancies. The impairment did not seem to be present before onset of disease. Women with preeclampsia without severe features did not have impaired cognitive function.</p>}},
author = {{Bergman, Lina and Thorgeirsdottir, Lilja and Elden, Helen and Hesselman, Susanne and Schell, Sonja and Ahlm, Evelina and Aukes, Annet and Cluver, Catherine}},
issn = {{0001-6349}},
keywords = {{cognitive function; eclampsia; preeclampsia; pulmonary edema}},
language = {{eng}},
number = {{7}},
pages = {{1280--1287}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Obstetricia et Gynecologica Scandinavica}},
title = {{Cognitive impairment in preeclampsia complicated by eclampsia and pulmonary edema after delivery}},
url = {{http://dx.doi.org/10.1111/aogs.14100}},
doi = {{10.1111/aogs.14100}},
volume = {{100}},
year = {{2021}},
}