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Biocompatibility and bone regeneration with elastin-like recombinamer-based catalyst-free click gels

Camal Ruggieri, I. N. ; Aimone, M. ; Juanes-Gusano, D. ; Ibáñez-Fonseca, A. LU orcid ; Santiago, O. ; Stur, M. ; Mardegan Issa, J. P. ; Missana, L. R. ; Alonso, M. and Rodríguez-Cabello, J. C. , et al. (2024) In Scientific Reports 14. p.1-16
Abstract

Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based on Elastin-Like Recombinamers-based click-chemistry hydrogels given their high biocompatibility and their potent on bone regeneration effect conferred by different bioactive sequences. In this work we demonstrate, using biochemistry, histology, histomorphometry and imaging techniques, the biocompatibility of our matrix and its potent effect on bone regeneration in a model of bone parietal lesion in female New Zealand rabbits.

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publishing date
type
Contribution to journal
publication status
published
keywords
Bone, Elastin, Scaffold, Tissue engineering
in
Scientific Reports
volume
14
article number
20223
pages
1 - 16
publisher
Nature Publishing Group
external identifiers
  • scopus:85202745898
  • pmid:39215050
ISSN
2045-2322
DOI
10.1038/s41598-024-69658-z
language
English
LU publication?
no
additional info
Publisher Copyright: © The Author(s) 2024.
id
d3152aaa-5e47-4747-85ce-0bf746aaf92b
date added to LUP
2025-09-14 19:53:40
date last changed
2025-10-14 13:12:59
@article{d3152aaa-5e47-4747-85ce-0bf746aaf92b,
  abstract     = {{<p>Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based on Elastin-Like Recombinamers-based click-chemistry hydrogels given their high biocompatibility and their potent on bone regeneration effect conferred by different bioactive sequences. In this work we demonstrate, using biochemistry, histology, histomorphometry and imaging techniques, the biocompatibility of our matrix and its potent effect on bone regeneration in a model of bone parietal lesion in female New Zealand rabbits.</p>}},
  author       = {{Camal Ruggieri, I. N. and Aimone, M. and Juanes-Gusano, D. and Ibáñez-Fonseca, A. and Santiago, O. and Stur, M. and Mardegan Issa, J. P. and Missana, L. R. and Alonso, M. and Rodríguez-Cabello, J. C. and Feldman, S.}},
  issn         = {{2045-2322}},
  keywords     = {{Bone; Elastin; Scaffold; Tissue engineering}},
  language     = {{eng}},
  pages        = {{1--16}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Biocompatibility and bone regeneration with elastin-like recombinamer-based catalyst-free click gels}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-69658-z}},
  doi          = {{10.1038/s41598-024-69658-z}},
  volume       = {{14}},
  year         = {{2024}},
}