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Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

Karlberg, Tobias LU ; Langelier, Marie-France ; Pascal, John M and Schüler, Herwig LU orcid (2013) In Molecular Aspects of Medicine 34(6). p.108-1088
Abstract

ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
ADP Ribose Transferases/chemistry, Animals, Bacteria/enzymology, Binding Sites, DNA Damage, Gene Expression Regulation, Glycoside Hydrolases/chemistry, Humans, Models, Molecular, Poly Adenosine Diphosphate Ribose/chemistry, Poly(ADP-ribose) Polymerases/chemistry, Protein Interaction Domains and Motifs, Protein Processing, Post-Translational, Protein Structure, Tertiary, Signal Transduction, Tankyrases/chemistry
in
Molecular Aspects of Medicine
volume
34
issue
6
pages
21 pages
publisher
Elsevier
external identifiers
  • scopus:84886727115
  • pmid:23458732
ISSN
0098-2997
DOI
10.1016/j.mam.2013.02.002
language
English
LU publication?
no
additional info
Copyright © 2013 Elsevier Ltd. All rights reserved.
id
d334870e-f183-4b42-9a39-48706ae7ae8b
date added to LUP
2024-11-21 17:57:14
date last changed
2025-06-07 08:55:45
@article{d334870e-f183-4b42-9a39-48706ae7ae8b,
  abstract     = {{<p>ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation.</p>}},
  author       = {{Karlberg, Tobias and Langelier, Marie-France and Pascal, John M and Schüler, Herwig}},
  issn         = {{0098-2997}},
  keywords     = {{ADP Ribose Transferases/chemistry; Animals; Bacteria/enzymology; Binding Sites; DNA Damage; Gene Expression Regulation; Glycoside Hydrolases/chemistry; Humans; Models, Molecular; Poly Adenosine Diphosphate Ribose/chemistry; Poly(ADP-ribose) Polymerases/chemistry; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Structure, Tertiary; Signal Transduction; Tankyrases/chemistry}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{108--1088}},
  publisher    = {{Elsevier}},
  series       = {{Molecular Aspects of Medicine}},
  title        = {{Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling}},
  url          = {{http://dx.doi.org/10.1016/j.mam.2013.02.002}},
  doi          = {{10.1016/j.mam.2013.02.002}},
  volume       = {{34}},
  year         = {{2013}},
}