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Interleukin-15 affects differentiation and apoptosis in adipocytes : implications in obesity

Fuster, Gemma ; Almendro, Vanessa ; Fontes-Oliveira, Cibely Cristine LU ; Toledo, Míriam ; Costelli, Paola ; Busquets, Sílvia ; López-Soriano, Francisco J and Argilés, Josep M (2011) In Lipids 46(11). p.42-1033
Abstract

Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In... (More)

Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In conclusion, using the 3T3-L1 adipocyte cell line, the results presented here show that IL-15 exerts important effects on differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies.

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author
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publishing date
type
Contribution to journal
publication status
published
keywords
3T3-L1 Cells, Adipocytes, Animals, Antigens, Differentiation, Apoptosis Regulatory Proteins, Azo Compounds, Cell Differentiation, Cell Proliferation, Gene Expression, Interleukin-15, MAP Kinase Signaling System, Mice, Mitogen-Activated Protein Kinases, Obesity, Journal Article, Research Support, Non-U.S. Gov't
in
Lipids
volume
46
issue
11
pages
42 - 1033
publisher
Springer
external identifiers
  • pmid:21894465
  • scopus:83555164822
ISSN
0024-4201
DOI
10.1007/s11745-011-3594-5
language
English
LU publication?
no
id
d340dbf7-2251-4f25-828f-72f400cb36be
date added to LUP
2017-02-28 16:13:17
date last changed
2024-07-07 13:27:38
@article{d340dbf7-2251-4f25-828f-72f400cb36be,
  abstract     = {{<p>Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In conclusion, using the 3T3-L1 adipocyte cell line, the results presented here show that IL-15 exerts important effects on differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies.</p>}},
  author       = {{Fuster, Gemma and Almendro, Vanessa and Fontes-Oliveira, Cibely Cristine and Toledo, Míriam and Costelli, Paola and Busquets, Sílvia and López-Soriano, Francisco J and Argilés, Josep M}},
  issn         = {{0024-4201}},
  keywords     = {{3T3-L1 Cells; Adipocytes; Animals; Antigens, Differentiation; Apoptosis Regulatory Proteins; Azo Compounds; Cell Differentiation; Cell Proliferation; Gene Expression; Interleukin-15; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Obesity; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{42--1033}},
  publisher    = {{Springer}},
  series       = {{Lipids}},
  title        = {{Interleukin-15 affects differentiation and apoptosis in adipocytes : implications in obesity}},
  url          = {{http://dx.doi.org/10.1007/s11745-011-3594-5}},
  doi          = {{10.1007/s11745-011-3594-5}},
  volume       = {{46}},
  year         = {{2011}},
}