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Interleukin-15 affects differentiation and apoptosis in adipocytes : implications in obesity

Fuster, Gemma; Almendro, Vanessa; Fontes-Oliveira, Cibely Cristine LU ; Toledo, Míriam; Costelli, Paola; Busquets, Sílvia; López-Soriano, Francisco J and Argilés, Josep M (2011) In Lipids 46(11). p.42-1033
Abstract

Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In... (More)

Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In conclusion, using the 3T3-L1 adipocyte cell line, the results presented here show that IL-15 exerts important effects on differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies.

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publication status
published
keywords
3T3-L1 Cells, Adipocytes, Animals, Antigens, Differentiation, Apoptosis Regulatory Proteins, Azo Compounds, Cell Differentiation, Cell Proliferation, Gene Expression, Interleukin-15, MAP Kinase Signaling System, Mice, Mitogen-Activated Protein Kinases, Obesity, Journal Article, Research Support, Non-U.S. Gov't
in
Lipids
volume
46
issue
11
pages
42 - 1033
publisher
Springer
external identifiers
  • scopus:83555164822
ISSN
0024-4201
DOI
10.1007/s11745-011-3594-5
language
English
LU publication?
no
id
d340dbf7-2251-4f25-828f-72f400cb36be
date added to LUP
2017-02-28 16:13:17
date last changed
2017-09-24 05:08:10
@article{d340dbf7-2251-4f25-828f-72f400cb36be,
  abstract     = {<p>Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In conclusion, using the 3T3-L1 adipocyte cell line, the results presented here show that IL-15 exerts important effects on differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies.</p>},
  author       = {Fuster, Gemma and Almendro, Vanessa and Fontes-Oliveira, Cibely Cristine and Toledo, Míriam and Costelli, Paola and Busquets, Sílvia and López-Soriano, Francisco J and Argilés, Josep M},
  issn         = {0024-4201},
  keyword      = {3T3-L1 Cells,Adipocytes,Animals,Antigens, Differentiation,Apoptosis Regulatory Proteins,Azo Compounds,Cell Differentiation,Cell Proliferation,Gene Expression,Interleukin-15,MAP Kinase Signaling System,Mice,Mitogen-Activated Protein Kinases,Obesity,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {11},
  pages        = {42--1033},
  publisher    = {Springer},
  series       = {Lipids},
  title        = {Interleukin-15 affects differentiation and apoptosis in adipocytes : implications in obesity},
  url          = {http://dx.doi.org/10.1007/s11745-011-3594-5},
  volume       = {46},
  year         = {2011},
}