Interleukin-15 affects differentiation and apoptosis in adipocytes : implications in obesity
(2011) In Lipids 46(11). p.42-1033- Abstract
Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In... (More)
Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In conclusion, using the 3T3-L1 adipocyte cell line, the results presented here show that IL-15 exerts important effects on differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies.
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- author
- Fuster, Gemma ; Almendro, Vanessa ; Fontes-Oliveira, Cibely Cristine LU ; Toledo, Míriam ; Costelli, Paola ; Busquets, Sílvia ; López-Soriano, Francisco J and Argilés, Josep M
- publishing date
- 2011-11
- type
- Contribution to journal
- publication status
- published
- keywords
- 3T3-L1 Cells, Adipocytes, Animals, Antigens, Differentiation, Apoptosis Regulatory Proteins, Azo Compounds, Cell Differentiation, Cell Proliferation, Gene Expression, Interleukin-15, MAP Kinase Signaling System, Mice, Mitogen-Activated Protein Kinases, Obesity, Journal Article, Research Support, Non-U.S. Gov't
- in
- Lipids
- volume
- 46
- issue
- 11
- pages
- 42 - 1033
- publisher
- Springer
- external identifiers
-
- pmid:21894465
- scopus:83555164822
- ISSN
- 0024-4201
- DOI
- 10.1007/s11745-011-3594-5
- language
- English
- LU publication?
- no
- id
- d340dbf7-2251-4f25-828f-72f400cb36be
- date added to LUP
- 2017-02-28 16:13:17
- date last changed
- 2024-07-07 13:27:38
@article{d340dbf7-2251-4f25-828f-72f400cb36be, abstract = {{<p>Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In conclusion, using the 3T3-L1 adipocyte cell line, the results presented here show that IL-15 exerts important effects on differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies.</p>}}, author = {{Fuster, Gemma and Almendro, Vanessa and Fontes-Oliveira, Cibely Cristine and Toledo, Míriam and Costelli, Paola and Busquets, Sílvia and López-Soriano, Francisco J and Argilés, Josep M}}, issn = {{0024-4201}}, keywords = {{3T3-L1 Cells; Adipocytes; Animals; Antigens, Differentiation; Apoptosis Regulatory Proteins; Azo Compounds; Cell Differentiation; Cell Proliferation; Gene Expression; Interleukin-15; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Obesity; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{11}}, pages = {{42--1033}}, publisher = {{Springer}}, series = {{Lipids}}, title = {{Interleukin-15 affects differentiation and apoptosis in adipocytes : implications in obesity}}, url = {{http://dx.doi.org/10.1007/s11745-011-3594-5}}, doi = {{10.1007/s11745-011-3594-5}}, volume = {{46}}, year = {{2011}}, }