Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Interleukin-15 affects differentiation and apoptosis in adipocytes : implications in obesity

Fuster, Gemma ; Almendro, Vanessa ; Fontes-Oliveira, Cibely Cristine LU ; Toledo, Míriam ; Costelli, Paola ; Busquets, Sílvia ; López-Soriano, Francisco J and Argilés, Josep M (2011) In Lipids 46(11). p.42-1033
Abstract

Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In... (More)

Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In conclusion, using the 3T3-L1 adipocyte cell line, the results presented here show that IL-15 exerts important effects on differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
3T3-L1 Cells, Adipocytes, Animals, Antigens, Differentiation, Apoptosis Regulatory Proteins, Azo Compounds, Cell Differentiation, Cell Proliferation, Gene Expression, Interleukin-15, MAP Kinase Signaling System, Mice, Mitogen-Activated Protein Kinases, Obesity, Journal Article, Research Support, Non-U.S. Gov't
in
Lipids
volume
46
issue
11
pages
42 - 1033
publisher
Springer
external identifiers
  • scopus:83555164822
  • pmid:21894465
ISSN
0024-4201
DOI
10.1007/s11745-011-3594-5
language
English
LU publication?
no
id
d340dbf7-2251-4f25-828f-72f400cb36be
date added to LUP
2017-02-28 16:13:17
date last changed
2024-07-07 13:27:38
@article{d340dbf7-2251-4f25-828f-72f400cb36be,
  abstract     = {{<p>Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the 3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis, and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44 MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15). In conclusion, using the 3T3-L1 adipocyte cell line, the results presented here show that IL-15 exerts important effects on differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies.</p>}},
  author       = {{Fuster, Gemma and Almendro, Vanessa and Fontes-Oliveira, Cibely Cristine and Toledo, Míriam and Costelli, Paola and Busquets, Sílvia and López-Soriano, Francisco J and Argilés, Josep M}},
  issn         = {{0024-4201}},
  keywords     = {{3T3-L1 Cells; Adipocytes; Animals; Antigens, Differentiation; Apoptosis Regulatory Proteins; Azo Compounds; Cell Differentiation; Cell Proliferation; Gene Expression; Interleukin-15; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Obesity; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{42--1033}},
  publisher    = {{Springer}},
  series       = {{Lipids}},
  title        = {{Interleukin-15 affects differentiation and apoptosis in adipocytes : implications in obesity}},
  url          = {{http://dx.doi.org/10.1007/s11745-011-3594-5}},
  doi          = {{10.1007/s11745-011-3594-5}},
  volume       = {{46}},
  year         = {{2011}},
}