Leukocyte telomere length in relation to pancreatic cancer risk: a prospective study.
(2014) In Cancer Epidemiology Biomarkers & Prevention 23(11). p.2447-2454- Abstract
- Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk, the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Two studies have addressed the association of LTL in relation to pancreatic cancer risk and the results are contrasting. Methods: we measured LTL in a prospective study of 331 pancreatic cancer cases and 331 controls in the context of the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: We observed that the mean LTL was... (More)
- Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk, the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Two studies have addressed the association of LTL in relation to pancreatic cancer risk and the results are contrasting. Methods: we measured LTL in a prospective study of 331 pancreatic cancer cases and 331 controls in the context of the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: We observed that the mean LTL was higher in cases (0.59±0.20) than in controls (0.57±0.17), although this difference was not statistically significant (p=0.07), and a basic logistic regression model showed no association of LTL with pancreas cancer risk. When adjusting for levels of HbA1c and C-Peptide, however, there was a weakly positive association between longer LTL and pancreatic cancer risk , OR=1.13 (1.01-1.27). Additional analyses by cubic spline regression suggested a possible non-linear relationship between RTL and pancreatic cancer risk (P=0.022), with a statistically non-significant increase in risk at very low LTL, as well as a significant increase at high LTL. Conclusion: Taken together, the results from our study do not support LTL as a uniform and strong predictor of pancreatic cancer. Impact: The results of this manuscript can provide insights into telomere dynamics and highlight the complex relationship between LTL and pancreatic cancer risk. (Less)
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- publishing date
- 2014
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- published
- subject
- in
- Cancer Epidemiology Biomarkers & Prevention
- volume
- 23
- issue
- 11
- pages
- 2447 - 2454
- publisher
- American Association for Cancer Research
- external identifiers
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- pmid:25103821
- wos:000345279600028
- scopus:84918835252
- pmid:25103821
- ISSN
- 1538-7755
- DOI
- 10.1158/1055-9965.EPI-14-0247
- language
- English
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- yes
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- d35474ab-67c1-4f01-8a9b-db3f2291a1b6 (old id 4615383)
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@article{d35474ab-67c1-4f01-8a9b-db3f2291a1b6,
abstract = {{Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk, the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Two studies have addressed the association of LTL in relation to pancreatic cancer risk and the results are contrasting. Methods: we measured LTL in a prospective study of 331 pancreatic cancer cases and 331 controls in the context of the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: We observed that the mean LTL was higher in cases (0.59±0.20) than in controls (0.57±0.17), although this difference was not statistically significant (p=0.07), and a basic logistic regression model showed no association of LTL with pancreas cancer risk. When adjusting for levels of HbA1c and C-Peptide, however, there was a weakly positive association between longer LTL and pancreatic cancer risk , OR=1.13 (1.01-1.27). Additional analyses by cubic spline regression suggested a possible non-linear relationship between RTL and pancreatic cancer risk (P=0.022), with a statistically non-significant increase in risk at very low LTL, as well as a significant increase at high LTL. Conclusion: Taken together, the results from our study do not support LTL as a uniform and strong predictor of pancreatic cancer. Impact: The results of this manuscript can provide insights into telomere dynamics and highlight the complex relationship between LTL and pancreatic cancer risk.}},
author = {{Campa, Daniele and Mergarten, Björn and De Vivo, Immaculata and Boutron-Ruault, Marie-Christine and Racine, Antoine and Severi, Gianluca and Nieters, Alexandra and Katzke, Verena A and Trichopoulou, Antonia and Yiannakouris, Nikos and Trichopoulos, Dimitrios and Boeing, Heiner and Quiros, J Ramon and Duell, Eric J and Molina-Montes, Esther and Huerta, Jose-Maria and Ardanaz, Eva and Dorronsoro, Miren and Khaw, Kay-Tee and Wareham, Nick and Travis, Ruth C and Palli, Domenico and Pala, Valeria and Tumino, Rosario and Naccarati, Alessio and Panico, Salvatore and Vineis, Paolo and Riboli, Elio and Siddiq, Afshan and Bueno-de-Mesquita, H B and Peeters, Petra H M and Nilsson, Peter and Sund, Malin and Ye, Weimin and Lund, Eiliv and Jareid, Mie and Weiderpass, Elisabete and Duarte-Salles, Talita and Kong, So Y and Stepien, Magdalena and Canzian, Federico and Kaaks, Rudolf}},
issn = {{1538-7755}},
language = {{eng}},
number = {{11}},
pages = {{2447--2454}},
publisher = {{American Association for Cancer Research}},
series = {{Cancer Epidemiology Biomarkers & Prevention}},
title = {{Leukocyte telomere length in relation to pancreatic cancer risk: a prospective study.}},
url = {{http://dx.doi.org/10.1158/1055-9965.EPI-14-0247}},
doi = {{10.1158/1055-9965.EPI-14-0247}},
volume = {{23}},
year = {{2014}},
}