Catechol-o-methyltransferase, polypeptide sequences and dna molecule coding therefor
Jalanko, Anu ; Kalkkinen, Nisse ; Lundström, Kenneth ; Salminen, Marjo ; H, Söderlund ; Tilgmann, Carola LU
and Ulmanen, Ismo
(1991)
WO1991011513 A3
- Abstract
- A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. Recombinant clones directed against the rat liver and human placenta COMT are identified and sequenced. The isolation of pure and recombinant COMT and antibodies thereto, according to the invention, is useful as a medical and pharmacological tool for the development of COMT inhibitors and as a clinical tool for the assay of COMT expression in various disease states.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/d359f84f-dce1-45b6-b22f-f3eac7b75b3d
- inventor
- Jalanko, Anu
; Kalkkinen, Nisse
; Lundström, Kenneth
; Salminen, Marjo
; H, Söderlund
; Tilgmann, Carola
LU
and Ulmanen, Ismo
- publishing date
- 1991-10-17
- type
- Patent
- publication status
- published
- subject
- keywords
- catechol-O-methyltransferase (COMT), Sequence Homology Amino Acid, enzmes
- patent number
- WO1991011513 A3
- language
- English
- LU publication?
- no
- id
- d359f84f-dce1-45b6-b22f-f3eac7b75b3d
- date added to LUP
- 2016-04-20 13:59:21
- date last changed
- 2019-03-08 02:21:40
@misc{d359f84f-dce1-45b6-b22f-f3eac7b75b3d,
abstract = {{A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. Recombinant clones directed against the rat liver and human placenta COMT are identified and sequenced. The isolation of pure and recombinant COMT and antibodies thereto, according to the invention, is useful as a medical and pharmacological tool for the development of COMT inhibitors and as a clinical tool for the assay of COMT expression in various disease states.}},
author = {{Jalanko, Anu and Kalkkinen, Nisse and Lundström, Kenneth and Salminen, Marjo and H, Söderlund and Tilgmann, Carola and Ulmanen, Ismo}},
keywords = {{catechol-O-methyltransferase (COMT); Sequence Homology Amino Acid; enzmes}},
language = {{eng}},
month = {{10}},
note = {{Patent, Patent Number: WO1991011513 A3}},
title = {{Catechol-o-methyltransferase, polypeptide sequences and dna molecule coding therefor}},
year = {{1991}},
}