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Catechol-o-methyltransferase, polypeptide sequences and dna molecule coding therefor

Jalanko, Anu; Kalkkinen, Nisse; Lundström, Kenneth; Salminen, Marjo; H, Söderlund; Tilgmann, Carola LU and Ulmanen, Ismo (1991) WO1991011513 A3
Abstract
A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. Recombinant clones directed against the rat liver and human placenta COMT are identified and sequenced. The isolation of pure and recombinant COMT and antibodies thereto, according to the invention, is useful as a medical and pharmacological tool for the development of COMT inhibitors and as a clinical tool for the assay of COMT expression in various disease states.
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author
publishing date
type
Patent
publication status
published
subject
keywords
catechol-O-methyltransferase (COMT), Sequence Homology Amino Acid, enzmes
patent number
WO1991011513 A3
language
English
LU publication?
no
id
d359f84f-dce1-45b6-b22f-f3eac7b75b3d
date added to LUP
2016-04-20 13:59:21
date last changed
2017-02-02 16:03:34
@misc{d359f84f-dce1-45b6-b22f-f3eac7b75b3d,
  abstract     = {A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. Recombinant clones directed against the rat liver and human placenta COMT are identified and sequenced. The isolation of pure and recombinant COMT and antibodies thereto, according to the invention, is useful as a medical and pharmacological tool for the development of COMT inhibitors and as a clinical tool for the assay of COMT expression in various disease states.},
  author       = {Jalanko, Anu and Kalkkinen, Nisse and Lundström, Kenneth and Salminen, Marjo and H, Söderlund and Tilgmann, Carola and Ulmanen, Ismo},
  keyword      = {catechol-O-methyltransferase (COMT),Sequence Homology Amino Acid,enzmes},
  language     = {eng},
  month        = {10},
  note         = {Patent, Patent Number: WO1991011513 A3},
  title        = {Catechol-o-methyltransferase, polypeptide sequences and dna molecule coding therefor},
  year         = {1991},
}