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Fabrication of Nanoemulsions by High-Pressure Valve Homogenization

Håkansson, Andreas LU (2018) p.175-206
Abstract

High-pressure valve homogenization is a standard technique for nanoemulsion formation in low-viscosity formulations. It is applied extensively in industrial applications and in academic research. This chapter summarizes the scientific-based knowledge in terms of principal mechanisms of operation and practical applicability of the methodology. It is concluded that high-pressure valve homogenization has many advantages in producing nanoemulsions; the technique is mature and allows for continuous production and for production in various scales. However, the technique also has limitations. The thermodynamic efficiency is low, giving rise to high energy cost, and a substantial temperature rises in the product. The high pressures required for... (More)

High-pressure valve homogenization is a standard technique for nanoemulsion formation in low-viscosity formulations. It is applied extensively in industrial applications and in academic research. This chapter summarizes the scientific-based knowledge in terms of principal mechanisms of operation and practical applicability of the methodology. It is concluded that high-pressure valve homogenization has many advantages in producing nanoemulsions; the technique is mature and allows for continuous production and for production in various scales. However, the technique also has limitations. The thermodynamic efficiency is low, giving rise to high energy cost, and a substantial temperature rises in the product. The high pressures required for nanoemulsion formation have also been reported to cause overprocessing, which results in an additional limitation.

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Please use this url to cite or link to this publication:
author
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
keywords
Coalescence, Fragmentation, High-energy emulsification, High-pressure valve homogenization, Nanoemulsion, Scale-up
host publication
Nanoemulsions : Formulation, Applications, and Characterization - Formulation, Applications, and Characterization
pages
32 pages
publisher
Elsevier Inc.
external identifiers
  • scopus:85053551487
ISBN
9780128118399
9780128118382
DOI
10.1016/B978-0-12-811838-2.00007-2
language
English
LU publication?
no
id
d36c5f1b-de06-43c1-9443-167a31b1193d
date added to LUP
2019-03-11 13:02:47
date last changed
2020-09-16 04:11:46
@inbook{d36c5f1b-de06-43c1-9443-167a31b1193d,
  abstract     = {<p>High-pressure valve homogenization is a standard technique for nanoemulsion formation in low-viscosity formulations. It is applied extensively in industrial applications and in academic research. This chapter summarizes the scientific-based knowledge in terms of principal mechanisms of operation and practical applicability of the methodology. It is concluded that high-pressure valve homogenization has many advantages in producing nanoemulsions; the technique is mature and allows for continuous production and for production in various scales. However, the technique also has limitations. The thermodynamic efficiency is low, giving rise to high energy cost, and a substantial temperature rises in the product. The high pressures required for nanoemulsion formation have also been reported to cause overprocessing, which results in an additional limitation.</p>},
  author       = {Håkansson, Andreas},
  booktitle    = {Nanoemulsions : Formulation, Applications, and Characterization},
  isbn         = {9780128118399},
  language     = {eng},
  month        = {03},
  pages        = {175--206},
  publisher    = {Elsevier Inc.},
  title        = {Fabrication of Nanoemulsions by High-Pressure Valve Homogenization},
  url          = {http://dx.doi.org/10.1016/B978-0-12-811838-2.00007-2},
  doi          = {10.1016/B978-0-12-811838-2.00007-2},
  year         = {2018},
}