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Vascular endothelial growth factor gene polymorphisms and pre-eclampsia

Papazoglou, D ; Galazios, G ; Koukourakis, MI ; Panagopoulos, Ioannis LU ; Kontomanolis, EN ; Papatheodorou, K and Maltezos, E (2004) In Molecular Human Reproduction 10(5). p.321-324
Abstract
Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between... (More)
Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09-6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
vascular endothelial growth factor, pre-eclampsia, polymorphisms
in
Molecular Human Reproduction
volume
10
issue
5
pages
321 - 324
publisher
Oxford University Press
external identifiers
  • pmid:14997002
  • wos:000221821100004
  • scopus:2642542363
  • pmid:14997002
ISSN
1460-2407
DOI
10.1093/molehr/gah048
language
English
LU publication?
yes
id
d37c1511-2257-4e40-a09e-8b61a40cf93e (old id 276170)
date added to LUP
2016-04-01 12:16:42
date last changed
2022-01-27 01:23:04
@article{d37c1511-2257-4e40-a09e-8b61a40cf93e,
  abstract     = {{Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09-6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification.}},
  author       = {{Papazoglou, D and Galazios, G and Koukourakis, MI and Panagopoulos, Ioannis and Kontomanolis, EN and Papatheodorou, K and Maltezos, E}},
  issn         = {{1460-2407}},
  keywords     = {{vascular endothelial growth factor; pre-eclampsia; polymorphisms}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{321--324}},
  publisher    = {{Oxford University Press}},
  series       = {{Molecular Human Reproduction}},
  title        = {{Vascular endothelial growth factor gene polymorphisms and pre-eclampsia}},
  url          = {{http://dx.doi.org/10.1093/molehr/gah048}},
  doi          = {{10.1093/molehr/gah048}},
  volume       = {{10}},
  year         = {{2004}},
}