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Association between occurrence of urinary bladder cancer and treatment with statin medication

Lundberg, Erik ; Hagberg, Oskar LU ; Jahnson, Staffan and Ljungberg, Borje (2019) In Turkish Journal of Urology 45(2). p.97-102
Abstract

Objective: The incidence of urinary bladder cancer (UBC) has increased in Sweden despite decreased smoking, indicating that other factors might be associated. The increased use of statin medication for elevated blood lipids might be one such influencing factor. The aim of the present study was to assess whether statins are afflicted with an increased incidence of UBC. Material and methods: Data from the Swedish National Register of Urinary Bladder Cancer, National Population Register, and Swedish Prescribed Drug Register were extracted. There were 22,936 patients with new diagnosed UBC between 2005 and 2014. Statin prescription was defined as any medication prescribed with the Anatomical Therapeutic Classification code C10A. For each... (More)

Objective: The incidence of urinary bladder cancer (UBC) has increased in Sweden despite decreased smoking, indicating that other factors might be associated. The increased use of statin medication for elevated blood lipids might be one such influencing factor. The aim of the present study was to assess whether statins are afflicted with an increased incidence of UBC. Material and methods: Data from the Swedish National Register of Urinary Bladder Cancer, National Population Register, and Swedish Prescribed Drug Register were extracted. There were 22,936 patients with new diagnosed UBC between 2005 and 2014. Statin prescription was defined as any medication prescribed with the Anatomical Therapeutic Classification code C10A. For each patient, 10 control individuals were matched by age, gender, and living area, comprising 229,326 individuals. The Cochran-Mantel-Haenszel test was used to evaluate the hazards ratios. Results: Statins were more frequently used in patients with UBC (33.8%) than in controls (29.8%, p<0.0001). The use of statins was afflicted with a 23% increased odds ratio (OR) for UBC (OR 1.23 (1.19-1.27), p<0.001). Subgroup analyses showed that an increased OR was found in non-muscle invasive UBC only. There was a tendency that OR was stronger for men and for younger patients. Limitations include its retrospective register- based design and potential risk of bias of confounding factors, such as smoking and body mass index. Conclusion: This nationwide register study suggests an association between the occurrence of UBC and patients using statins. The association was found in patients with non-muscle invasive disease only. Confounding factors, such as smoking, cannot be overruled.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diabetes, Incidence, Odds ratio, Smoking, Stage, Statin medication, Urinary bladder cancer
in
Turkish Journal of Urology
volume
45
issue
2
pages
6 pages
publisher
Aves
external identifiers
  • scopus:85067914690
  • pmid:30875287
ISSN
2149-3235
DOI
10.5152/tud.2019.94495
language
English
LU publication?
yes
id
d39ae9d6-8226-425e-b5ac-c6b35b26b633
date added to LUP
2019-07-10 13:32:51
date last changed
2020-01-13 02:13:18
@article{d39ae9d6-8226-425e-b5ac-c6b35b26b633,
  abstract     = {<p>Objective: The incidence of urinary bladder cancer (UBC) has increased in Sweden despite decreased smoking, indicating that other factors might be associated. The increased use of statin medication for elevated blood lipids might be one such influencing factor. The aim of the present study was to assess whether statins are afflicted with an increased incidence of UBC. Material and methods: Data from the Swedish National Register of Urinary Bladder Cancer, National Population Register, and Swedish Prescribed Drug Register were extracted. There were 22,936 patients with new diagnosed UBC between 2005 and 2014. Statin prescription was defined as any medication prescribed with the Anatomical Therapeutic Classification code C10A. For each patient, 10 control individuals were matched by age, gender, and living area, comprising 229,326 individuals. The Cochran-Mantel-Haenszel test was used to evaluate the hazards ratios. Results: Statins were more frequently used in patients with UBC (33.8%) than in controls (29.8%, p&lt;0.0001). The use of statins was afflicted with a 23% increased odds ratio (OR) for UBC (OR 1.23 (1.19-1.27), p&lt;0.001). Subgroup analyses showed that an increased OR was found in non-muscle invasive UBC only. There was a tendency that OR was stronger for men and for younger patients. Limitations include its retrospective register- based design and potential risk of bias of confounding factors, such as smoking and body mass index. Conclusion: This nationwide register study suggests an association between the occurrence of UBC and patients using statins. The association was found in patients with non-muscle invasive disease only. Confounding factors, such as smoking, cannot be overruled.</p>},
  author       = {Lundberg, Erik and Hagberg, Oskar and Jahnson, Staffan and Ljungberg, Borje},
  issn         = {2149-3235},
  language     = {eng},
  number       = {2},
  pages        = {97--102},
  publisher    = {Aves},
  series       = {Turkish Journal of Urology},
  title        = {Association between occurrence of urinary bladder cancer and treatment with statin medication},
  url          = {http://dx.doi.org/10.5152/tud.2019.94495},
  doi          = {10.5152/tud.2019.94495},
  volume       = {45},
  year         = {2019},
}