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Ganglion Cell Topography Indicates Pre- or Postnatal Damage to the Retro-Geniculate Visual System, Predicts Visual Field Function and May Identify Cerebral Visual Impairment in Children – A Multiple Case Study

Jacobson, Lena ; Lennartsson, Finn LU and Nilsson, Maria (2019) In Neuro-Ophthalmology 43(6). p.363-370
Abstract
In this paper, we quantify the degree of ganglion cell layer thinning due to retrograde trans-synaptic degeneration (RTSD) from retro-geniculate damage in six cases who had homonymous visual field defects known since childhood. Three had prenatal injuries, occurring close to mid-gestation and in the first parts of the early and late third trimester, respectively, and representing injuries at different early developmental stages. Three had later acquired injuries, at age 1.5, 4 and 13 years. The impact of the injury to the optic radiations was revealed by fibre tractography. The ganglion cell thinning corresponded with the visual field defects and the extent and location of the primary brain damage. The most important sign of RTSD was... (More)
In this paper, we quantify the degree of ganglion cell layer thinning due to retrograde trans-synaptic degeneration (RTSD) from retro-geniculate damage in six cases who had homonymous visual field defects known since childhood. Three had prenatal injuries, occurring close to mid-gestation and in the first parts of the early and late third trimester, respectively, and representing injuries at different early developmental stages. Three had later acquired injuries, at age 1.5, 4 and 13 years. The impact of the injury to the optic radiations was revealed by fibre tractography. The ganglion cell thinning corresponded with the visual field defects and the extent and location of the primary brain damage. The most important sign of RTSD was asymmetry of the ganglion cell topography within the macular area. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebral visual impairment, homonymous visual field defects, retinal ganglion cells, Retro-geniculate brain damage, retrograde trans-synaptic degeneration
in
Neuro-Ophthalmology
volume
43
issue
6
pages
8 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85076420071
  • pmid:32165894
ISSN
0165-8107
DOI
10.1080/01658107.2019.1583760
language
English
LU publication?
yes
id
d3a5f650-a00a-49f4-81c9-7a3b1ed11637
date added to LUP
2019-05-22 12:39:58
date last changed
2024-01-15 21:22:08
@article{d3a5f650-a00a-49f4-81c9-7a3b1ed11637,
  abstract     = {{In this paper, we quantify the degree of ganglion cell layer thinning due to retrograde trans-synaptic degeneration (RTSD) from retro-geniculate damage in six cases who had homonymous visual field defects known since childhood. Three had prenatal injuries, occurring close to mid-gestation and in the first parts of the early and late third trimester, respectively, and representing injuries at different early developmental stages. Three had later acquired injuries, at age 1.5, 4 and 13 years. The impact of the injury to the optic radiations was revealed by fibre tractography. The ganglion cell thinning corresponded with the visual field defects and the extent and location of the primary brain damage. The most important sign of RTSD was asymmetry of the ganglion cell topography within the macular area.}},
  author       = {{Jacobson, Lena and Lennartsson, Finn and Nilsson, Maria}},
  issn         = {{0165-8107}},
  keywords     = {{cerebral visual impairment, homonymous visual field defects, retinal ganglion cells, Retro-geniculate brain damage, retrograde trans-synaptic degeneration}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{6}},
  pages        = {{363--370}},
  publisher    = {{Taylor & Francis}},
  series       = {{Neuro-Ophthalmology}},
  title        = {{Ganglion Cell Topography Indicates Pre- or Postnatal Damage to the Retro-Geniculate Visual System, Predicts Visual Field Function and May Identify Cerebral Visual Impairment in Children – A Multiple Case Study}},
  url          = {{http://dx.doi.org/10.1080/01658107.2019.1583760}},
  doi          = {{10.1080/01658107.2019.1583760}},
  volume       = {{43}},
  year         = {{2019}},
}