Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors
Samuelsson, Daniel ; Sznage, Monika LU
; Engelsberg, Karl
LU
and Wittström, Elisabeth
LU
(2016)
In Clinical Ophthalmology
10.
p.1953-1964
- Abstract
PURPOSE: To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intraocular tumors and determine if OCT and FAF could be helpful in the differential diagnosis and management of different choroidal tumors.
METHODS: Forty-nine patients with untreated, macular, midperipheral, and extrapapillary intraocular tumors were included. All patients underwent ophthalmic examination: best-corrected visual acuity, slit-lamp biomicroscopy, funduscopy, and standardized B mode, and if possible A mode, ultrasonography, and OCT and FAF imaging of the surface of the intraocular tumors.
RESULTS: Of the 49 patients studied, 19 had choroidal nevi, ten had indeterminate choroidal... (More)
PURPOSE: To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intraocular tumors and determine if OCT and FAF could be helpful in the differential diagnosis and management of different choroidal tumors.
METHODS: Forty-nine patients with untreated, macular, midperipheral, and extrapapillary intraocular tumors were included. All patients underwent ophthalmic examination: best-corrected visual acuity, slit-lamp biomicroscopy, funduscopy, and standardized B mode, and if possible A mode, ultrasonography, and OCT and FAF imaging of the surface of the intraocular tumors.
RESULTS: Of the 49 patients studied, 19 had choroidal nevi, ten had indeterminate choroidal melanocytic lesions (IMLs), ten had malignant melanomas, and ten had other choroidal tumors. The choroidal nevi revealed subretinal fluid (SRF) on OCT in only 11%. FAF detected isoauto-fluorescence in 42%, hypoautofluorescence in 37%, patchy FAF pattern in 16%, and a diffuse FAF pattern in 5%. Seventy percent of patients with IML showed SRF on OCT and 20% showed tumor growth on follow-up, detected only by OCT and FAF imaging. FAF revealed a patchy pattern in 50% and a diffuse pattern in 40% of cases with IML. Ninety percent of the patients with choroidal melanoma had SRF on OCT and FAF revealed a patchy pattern in 60% and a diffuse pattern in 40%. Patients with other choroidal tumors had SRF on OCT in 30% of cases and no characteristic pattern on FAF.
CONCLUSION: Both OCT and FAF were helpful in the differential diagnosis of choroidal nevi versus IMLs, choroidal melanomas, and other choroidal tumors. Also, detailed and periodical clinical evaluation of patients with intraocular tumors using OCT and FAF imaging for the detection of both SRF and FAF patterns overlying the tumor can be useful for detection of tumor growth.
(Less)
- author
- Samuelsson, Daniel
; Sznage, Monika
LU
; Engelsberg, Karl
LU
and Wittström, Elisabeth
LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Fundus autofluorescence, Intraocular tumors, Optical coherence tomography, Tumor growth
- in
- Clinical Ophthalmology
- volume
- 10
- pages
- 12 pages
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- pmid:27784984
- pmid:27784984
- wos:000385307900003
- scopus:85053361263
- ISSN
- 1177-5467
- DOI
- 10.2147/OPTH.S109222
- project
- Retinal structure, function and genetics in inherited and aquired retinal degenerative disease
- language
- English
- LU publication?
- yes
- id
- d4543a55-aca9-47a2-b3aa-08750672bee6
- date added to LUP
- 2016-11-16 08:09:06
- date last changed
- 2024-06-14 17:51:48
@article{d4543a55-aca9-47a2-b3aa-08750672bee6,
abstract = {{<p>PURPOSE: To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intraocular tumors and determine if OCT and FAF could be helpful in the differential diagnosis and management of different choroidal tumors.</p><p>METHODS: Forty-nine patients with untreated, macular, midperipheral, and extrapapillary intraocular tumors were included. All patients underwent ophthalmic examination: best-corrected visual acuity, slit-lamp biomicroscopy, funduscopy, and standardized B mode, and if possible A mode, ultrasonography, and OCT and FAF imaging of the surface of the intraocular tumors.</p><p>RESULTS: Of the 49 patients studied, 19 had choroidal nevi, ten had indeterminate choroidal melanocytic lesions (IMLs), ten had malignant melanomas, and ten had other choroidal tumors. The choroidal nevi revealed subretinal fluid (SRF) on OCT in only 11%. FAF detected isoauto-fluorescence in 42%, hypoautofluorescence in 37%, patchy FAF pattern in 16%, and a diffuse FAF pattern in 5%. Seventy percent of patients with IML showed SRF on OCT and 20% showed tumor growth on follow-up, detected only by OCT and FAF imaging. FAF revealed a patchy pattern in 50% and a diffuse pattern in 40% of cases with IML. Ninety percent of the patients with choroidal melanoma had SRF on OCT and FAF revealed a patchy pattern in 60% and a diffuse pattern in 40%. Patients with other choroidal tumors had SRF on OCT in 30% of cases and no characteristic pattern on FAF.</p><p>CONCLUSION: Both OCT and FAF were helpful in the differential diagnosis of choroidal nevi versus IMLs, choroidal melanomas, and other choroidal tumors. Also, detailed and periodical clinical evaluation of patients with intraocular tumors using OCT and FAF imaging for the detection of both SRF and FAF patterns overlying the tumor can be useful for detection of tumor growth.</p>}},
author = {{Samuelsson, Daniel and Sznage, Monika and Engelsberg, Karl and Wittström, Elisabeth}},
issn = {{1177-5467}},
keywords = {{Fundus autofluorescence; Intraocular tumors; Optical coherence tomography; Tumor growth}},
language = {{eng}},
pages = {{1953--1964}},
publisher = {{Dove Medical Press Ltd.}},
series = {{Clinical Ophthalmology}},
title = {{Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors}},
url = {{http://dx.doi.org/10.2147/OPTH.S109222}},
doi = {{10.2147/OPTH.S109222}},
volume = {{10}},
year = {{2016}},
}