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Apolipoprotein E genotypes and longevity across dementia disorders

Skillbäck, Tobias; Lautner, Ronald; Mattsson, Niklas LU ; Schott, Jonathan M.; Nägga, Katarina LU ; Kilander, Lena; Wimo, Anders; Winblad, Bengt; Eriksdotter, Maria and Blennow, Kaj LU , et al. (2018) In Alzheimer's and Dementia 14(7). p.895-901
Abstract

Introduction: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. Methods: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity. Results: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P =.006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P =.028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to... (More)

Introduction: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. Methods: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity. Results: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P =.006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P =.028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders. Discussion: The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.

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published
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keywords
Alzheimer's disease, Apolipoprotein E, Creutzfeldt-Jakob disease, Dementia with Lewy bodies, Frontotemporal dementia, Parkinson's disease dementia, Vascular dementia
in
Alzheimer's and Dementia
volume
14
issue
7
pages
895 - 901
publisher
Elsevier
external identifiers
  • scopus:85045326265
ISSN
1552-5260
DOI
10.1016/j.jalz.2018.02.003
language
English
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yes
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d45e54a9-1660-4eed-8821-f5b4ff7808df
date added to LUP
2018-04-24 14:27:08
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2019-03-12 04:09:06
@article{d45e54a9-1660-4eed-8821-f5b4ff7808df,
  abstract     = {<p>Introduction: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. Methods: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity. Results: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P =.006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P =.028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders. Discussion: The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.</p>},
  author       = {Skillbäck, Tobias and Lautner, Ronald and Mattsson, Niklas and Schott, Jonathan M. and Nägga, Katarina and Kilander, Lena and Wimo, Anders and Winblad, Bengt and Eriksdotter, Maria and Blennow, Kaj and Zetterberg, Henrik},
  issn         = {1552-5260},
  keyword      = {Alzheimer's disease,Apolipoprotein E,Creutzfeldt-Jakob disease,Dementia with Lewy bodies,Frontotemporal dementia,Parkinson's disease dementia,Vascular dementia},
  language     = {eng},
  number       = {7},
  pages        = {895--901},
  publisher    = {Elsevier},
  series       = {Alzheimer's and Dementia},
  title        = {Apolipoprotein E genotypes and longevity across dementia disorders},
  url          = {http://dx.doi.org/10.1016/j.jalz.2018.02.003},
  volume       = {14},
  year         = {2018},
}