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Self-reported executive functioning in adults with congenital cytomegalovirus infection

Falkenius Schmidt, Karolina LU ; Nyström, Anastasia LU ; Ehinger, Johannes LU orcid ; Karltorp, Eva ; Magnusson, Måns LU orcid and Löfkvist, Ulrika (2025) In Infectious Diseases 57(9). p.819-825
Abstract

BACKGROUND: Congenital Cytomegalovirus (cCMV) is the most common prenatal infection and the main infectious cause of neurodevelopmental abnormalities in developed countries. Long-term neuropsychological outcome of cCMV infection is yet not well understood, and follow-up studies on adults screened for CMV at birth are few. The aim of this study was to investigate self-reported executive functioning (EF) in adults with cCMV infection in relation to uninfected controls.

METHOD: All individuals from a universal newborn CMV screening study conducted in Southern Sweden and sampled 1977-85, was invited to participate in a follow-up study. 45/71 individuals (63%) with cCMV infection and 25/46 controls (54%) were enrolled. Participants... (More)

BACKGROUND: Congenital Cytomegalovirus (cCMV) is the most common prenatal infection and the main infectious cause of neurodevelopmental abnormalities in developed countries. Long-term neuropsychological outcome of cCMV infection is yet not well understood, and follow-up studies on adults screened for CMV at birth are few. The aim of this study was to investigate self-reported executive functioning (EF) in adults with cCMV infection in relation to uninfected controls.

METHOD: All individuals from a universal newborn CMV screening study conducted in Southern Sweden and sampled 1977-85, was invited to participate in a follow-up study. 45/71 individuals (63%) with cCMV infection and 25/46 controls (54%) were enrolled. Participants were aged 34-43 years. Neurological symptoms and neuropsychiatric disabilities were documented through written reports from the original study and a semi-structured study protocol. Executive functioning was evaluated with BRIEF-A (questionnaire).

RESULTS: No statistically significant differences were found between groups in self-reported executive functioning, although greater variability in outcomes was observed in the cCMV group.

CONCLUSION: Everyday executive functioning might not be affected at the group level in adults with cCMV infection or may not be adequately captured through self-reports alone. The variability in executive functioning results suggests that individuals with cCMV infection represent a more heterogeneous group compared to the controls.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adults, BRIEF-A, Congenital cytomegalovirus infection, executive functions, long-term follow-up
in
Infectious Diseases
volume
57
issue
9
pages
819 - 825
publisher
Taylor & Francis
external identifiers
  • pmid:40176451
  • scopus:105002603327
  • pmid:40176451
ISSN
2374-4235
DOI
10.1080/23744235.2025.2486714
language
English
LU publication?
yes
id
d4610557-034a-4412-b653-fba371454b4a
date added to LUP
2025-04-10 13:35:58
date last changed
2025-10-23 23:46:23
@article{d4610557-034a-4412-b653-fba371454b4a,
  abstract     = {{<p>BACKGROUND: Congenital Cytomegalovirus (cCMV) is the most common prenatal infection and the main infectious cause of neurodevelopmental abnormalities in developed countries. Long-term neuropsychological outcome of cCMV infection is yet not well understood, and follow-up studies on adults screened for CMV at birth are few. The aim of this study was to investigate self-reported executive functioning (EF) in adults with cCMV infection in relation to uninfected controls.</p><p>METHOD: All individuals from a universal newborn CMV screening study conducted in Southern Sweden and sampled 1977-85, was invited to participate in a follow-up study. 45/71 individuals (63%) with cCMV infection and 25/46 controls (54%) were enrolled. Participants were aged 34-43 years. Neurological symptoms and neuropsychiatric disabilities were documented through written reports from the original study and a semi-structured study protocol. Executive functioning was evaluated with BRIEF-A (questionnaire).</p><p>RESULTS: No statistically significant differences were found between groups in self-reported executive functioning, although greater variability in outcomes was observed in the cCMV group.</p><p>CONCLUSION: Everyday executive functioning might not be affected at the group level in adults with cCMV infection or may not be adequately captured through self-reports alone. The variability in executive functioning results suggests that individuals with cCMV infection represent a more heterogeneous group compared to the controls.</p>}},
  author       = {{Falkenius Schmidt, Karolina and Nyström, Anastasia and Ehinger, Johannes and Karltorp, Eva and Magnusson, Måns and Löfkvist, Ulrika}},
  issn         = {{2374-4235}},
  keywords     = {{adults; BRIEF-A; Congenital cytomegalovirus infection; executive functions; long-term follow-up}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{819--825}},
  publisher    = {{Taylor & Francis}},
  series       = {{Infectious Diseases}},
  title        = {{Self-reported executive functioning in adults with congenital cytomegalovirus infection}},
  url          = {{http://dx.doi.org/10.1080/23744235.2025.2486714}},
  doi          = {{10.1080/23744235.2025.2486714}},
  volume       = {{57}},
  year         = {{2025}},
}