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Ten-a overexpression causes abnormal pattern in the Drosophila compound eye

Ngernsiri, Lertluk ; Fascetti, Nora LU ; Romratanapan, Suppaluk and Baumgartner, Stefan LU orcid (2006) In Insect science 13(5). p.355-364
Abstract

Abstract Ten-a is one of the two Drosophila proteins that belong to the Ten M protein family. This protein is a type II transmembrane protein and is expressed mainly in the embryonic CNS, in the larval eye imaginal disc and in the compound eye of the pupa. Here, we investigate the role of ten-a during development of the compound eye by using the Gal4/UAS system to induce ten-a overexpression in the developing eye. We found that overexpression of ten-a can perturb eye development during all stages examined. In an early stage, overexpression of ten-a in eye primordial cells caused small and rough eyes and interfered with photoreceptor cell recruitment, resulting in some ommatidia having fewer or extra photoreceptor cells. Conversely,... (More)

Abstract Ten-a is one of the two Drosophila proteins that belong to the Ten M protein family. This protein is a type II transmembrane protein and is expressed mainly in the embryonic CNS, in the larval eye imaginal disc and in the compound eye of the pupa. Here, we investigate the role of ten-a during development of the compound eye by using the Gal4/UAS system to induce ten-a overexpression in the developing eye. We found that overexpression of ten-a can perturb eye development during all stages examined. In an early stage, overexpression of ten-a in eye primordial cells caused small and rough eyes and interfered with photoreceptor cell recruitment, resulting in some ommatidia having fewer or extra photoreceptor cells. Conversely, ten-a overexpression during ommatidial formation caused severe eye defects due to absence of many cellular components. Interestingly, overexpression of ten-a in the late stage developing ommatidial cluster affected the number of pigment cells, caused cone cells proliferation in many ommatidia, and caused some photoreceptor cell defects. These results suggest that ten-a may be a novel gene required for normal eye morphogenesis.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Compound eye, Drosophila, Gal4/UAS system, Ommatidia, Ten-a
in
Insect science
volume
13
issue
5
pages
355 - 364
publisher
Wiley-Blackwell
external identifiers
  • scopus:39549100750
ISSN
1672-9609
DOI
10.1111/j.1744-7917.2006.00104.x
language
English
LU publication?
yes
id
d4929379-48e5-43e9-ba43-adf861260dcc
date added to LUP
2019-05-21 14:04:11
date last changed
2021-06-23 04:03:36
@article{d4929379-48e5-43e9-ba43-adf861260dcc,
  abstract     = {<p>Abstract Ten-a is one of the two Drosophila proteins that belong to the Ten M protein family. This protein is a type II transmembrane protein and is expressed mainly in the embryonic CNS, in the larval eye imaginal disc and in the compound eye of the pupa. Here, we investigate the role of ten-a during development of the compound eye by using the Gal4/UAS system to induce ten-a overexpression in the developing eye. We found that overexpression of ten-a can perturb eye development during all stages examined. In an early stage, overexpression of ten-a in eye primordial cells caused small and rough eyes and interfered with photoreceptor cell recruitment, resulting in some ommatidia having fewer or extra photoreceptor cells. Conversely, ten-a overexpression during ommatidial formation caused severe eye defects due to absence of many cellular components. Interestingly, overexpression of ten-a in the late stage developing ommatidial cluster affected the number of pigment cells, caused cone cells proliferation in many ommatidia, and caused some photoreceptor cell defects. These results suggest that ten-a may be a novel gene required for normal eye morphogenesis.</p>},
  author       = {Ngernsiri, Lertluk and Fascetti, Nora and Romratanapan, Suppaluk and Baumgartner, Stefan},
  issn         = {1672-9609},
  language     = {eng},
  month        = {01},
  number       = {5},
  pages        = {355--364},
  publisher    = {Wiley-Blackwell},
  series       = {Insect science},
  title        = {Ten-a overexpression causes abnormal pattern in the Drosophila compound eye},
  url          = {http://dx.doi.org/10.1111/j.1744-7917.2006.00104.x},
  doi          = {10.1111/j.1744-7917.2006.00104.x},
  volume       = {13},
  year         = {2006},
}